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Gene: ZKSCAN8 |
Gene summary for ZKSCAN8 |
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Gene information | Species | Human | Gene symbol | ZKSCAN8 | Gene ID | 7745 |
Gene name | zinc finger with KRAB and SCAN domains 8 | |
Gene Alias | LD5-1 | |
Cytomap | 6p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024RCK7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7745 | ZKSCAN8 | HCC1_Meng | Human | Liver | HCC | 8.55e-27 | 1.70e-02 | 0.0246 |
7745 | ZKSCAN8 | HCC1 | Human | Liver | HCC | 1.45e-04 | 2.25e+00 | 0.5336 |
7745 | ZKSCAN8 | HCC2 | Human | Liver | HCC | 3.00e-03 | 1.28e+00 | 0.5341 |
7745 | ZKSCAN8 | S014 | Human | Liver | HCC | 1.57e-02 | 1.99e-01 | 0.2254 |
7745 | ZKSCAN8 | S016 | Human | Liver | HCC | 4.93e-03 | 1.92e-01 | 0.2243 |
7745 | ZKSCAN8 | S028 | Human | Liver | HCC | 2.66e-05 | 2.77e-01 | 0.2503 |
7745 | ZKSCAN8 | S029 | Human | Liver | HCC | 1.37e-05 | 3.03e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZKSCAN8 | MSC | Stomach | CAG with IM | TYW1B,ZNF524,REV1, etc. | 1.38e-01 | ![]() |
ZKSCAN8 | MVA | Stomach | SIM | TYW1B,ZNF524,REV1, etc. | 1.43e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZKSCAN8 | SNV | Missense_Mutation | c.899N>G | p.Glu300Gly | p.E300G | Q15776 | protein_coding | tolerated(1) | benign(0) | TCGA-37-4141-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZKSCAN8 | SNV | Missense_Mutation | novel | c.851N>T | p.Glu284Val | p.E284V | Q15776 | protein_coding | deleterious(0.02) | possibly_damaging(0.713) | TCGA-56-7222-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ZKSCAN8 | SNV | Missense_Mutation | novel | c.829N>G | p.Thr277Ala | p.T277A | Q15776 | protein_coding | tolerated(0.62) | benign(0) | TCGA-6A-AB49-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZKSCAN8 | SNV | Missense_Mutation | rs745845523 | c.22C>G | p.Pro8Ala | p.P8A | Q15776 | protein_coding | tolerated(1) | benign(0.001) | TCGA-85-8071-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZKSCAN8 | SNV | Missense_Mutation | novel | c.735N>T | p.Arg245Ser | p.R245S | Q15776 | protein_coding | deleterious(0.02) | benign(0.042) | TCGA-96-A4JK-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR |
ZKSCAN8 | SNV | Missense_Mutation | novel | c.289N>A | p.Glu97Lys | p.E97K | Q15776 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZKSCAN8 | SNV | Missense_Mutation | novel | c.1525N>G | p.Gln509Glu | p.Q509E | Q15776 | protein_coding | tolerated(0.27) | probably_damaging(0.986) | TCGA-98-8021-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZKSCAN8 | SNV | Missense_Mutation | novel | c.1361N>A | p.Arg454Lys | p.R454K | Q15776 | protein_coding | deleterious(0.01) | probably_damaging(0.972) | TCGA-MF-A522-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
ZKSCAN8 | SNV | Missense_Mutation | novel | c.797N>G | p.Asn266Ser | p.N266S | Q15776 | protein_coding | tolerated(0.41) | probably_damaging(0.97) | TCGA-CN-4727-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
ZKSCAN8 | SNV | Missense_Mutation | novel | c.236N>T | p.Trp79Leu | p.W79L | Q15776 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CV-6934-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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