![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZFC3H1 |
Gene summary for ZFC3H1 |
![]() |
Gene information | Species | Human | Gene symbol | ZFC3H1 | Gene ID | 196441 |
Gene name | zinc finger C3H1-type containing | |
Gene Alias | CCDC131 | |
Cytomap | 12q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O60293 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
196441 | ZFC3H1 | CCI_1 | Human | Cervix | CC | 2.43e-03 | 6.71e-01 | 0.528 |
196441 | ZFC3H1 | CCI_2 | Human | Cervix | CC | 3.77e-16 | 1.39e+00 | 0.5249 |
196441 | ZFC3H1 | CCI_3 | Human | Cervix | CC | 5.12e-16 | 1.13e+00 | 0.516 |
196441 | ZFC3H1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.89e-16 | -5.94e-01 | 0.0155 |
196441 | ZFC3H1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.72e-07 | -5.84e-01 | -0.1808 |
196441 | ZFC3H1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.67e-03 | -4.35e-01 | -0.0811 |
196441 | ZFC3H1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.43e-02 | -3.81e-01 | -0.1088 |
196441 | ZFC3H1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.53e-05 | -5.60e-01 | -0.1207 |
196441 | ZFC3H1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.19e-02 | -3.75e-01 | -0.1526 |
196441 | ZFC3H1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.66e-09 | -4.49e-01 | -0.1464 |
196441 | ZFC3H1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.44e-03 | -3.58e-01 | -0.1001 |
196441 | ZFC3H1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.33e-12 | -5.24e-01 | 0.096 |
196441 | ZFC3H1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.60e-04 | -3.96e-01 | 0.0338 |
196441 | ZFC3H1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.59e-04 | -3.48e-01 | 0.0674 |
196441 | ZFC3H1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.35e-06 | -5.17e-01 | 0.0588 |
196441 | ZFC3H1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.83e-04 | -3.57e-01 | 0.294 |
196441 | ZFC3H1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.28e-03 | -5.76e-01 | 0.2585 |
196441 | ZFC3H1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.37e-12 | -5.39e-01 | 0.3005 |
196441 | ZFC3H1 | A001-C-207 | Human | Colorectum | FAP | 4.91e-02 | -2.89e-02 | 0.1278 |
196441 | ZFC3H1 | A015-C-203 | Human | Colorectum | FAP | 9.89e-26 | -1.32e-01 | -0.1294 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFC3H1 | SNV | Missense_Mutation | c.5363A>G | p.Tyr1788Cys | p.Y1788C | O60293 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
ZFC3H1 | SNV | Missense_Mutation | novel | c.4798G>A | p.Ala1600Thr | p.A1600T | O60293 | protein_coding | tolerated(0.36) | benign(0.001) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ZFC3H1 | SNV | Missense_Mutation | rs373974920 | c.2087G>A | p.Arg696Gln | p.R696Q | O60293 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ZFC3H1 | SNV | Missense_Mutation | novel | c.4622N>C | p.Lys1541Thr | p.K1541T | O60293 | protein_coding | tolerated(0.21) | benign(0.297) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZFC3H1 | deletion | Frame_Shift_Del | novel | c.3143delN | p.Leu1048Ter | p.L1048* | O60293 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
ZFC3H1 | insertion | Frame_Shift_Ins | novel | c.650_651insA | p.Asn217LysfsTer2 | p.N217Kfs*2 | O60293 | protein_coding | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ZFC3H1 | insertion | Frame_Shift_Ins | novel | c.957_958insA | p.Val320SerfsTer2 | p.V320Sfs*2 | O60293 | protein_coding | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZFC3H1 | insertion | In_Frame_Ins | novel | c.5060_5061insAAAAAACTG | p.Asp1687delinsGluLysAsnCys | p.D1687delinsEKNC | O60293 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZFC3H1 | insertion | Frame_Shift_Ins | novel | c.3101_3102insCAGTATTTTTATT | p.Glu1034AspfsTer26 | p.E1034Dfs*26 | O60293 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZFC3H1 | insertion | Frame_Shift_Ins | novel | c.5078dupT | p.Leu1693PhefsTer10 | p.L1693Ffs*10 | O60293 | protein_coding | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |