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Gene: ZER1 |
Gene summary for ZER1 |
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Gene information | Species | Human | Gene symbol | ZER1 | Gene ID | 10444 |
Gene name | zyg-11 related cell cycle regulator | |
Gene Alias | C9orf60 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A024R8B0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10444 | ZER1 | CCI_2 | Human | Cervix | CC | 2.39e-09 | 7.69e-01 | 0.5249 |
10444 | ZER1 | CCI_3 | Human | Cervix | CC | 1.13e-07 | 5.45e-01 | 0.516 |
10444 | ZER1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.01e-10 | 4.97e-01 | -0.1954 |
10444 | ZER1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.83e-02 | 9.48e-01 | -0.2602 |
10444 | ZER1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.50e-11 | 5.37e-01 | -0.1464 |
10444 | ZER1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.29e-02 | 3.11e-01 | -0.0842 |
10444 | ZER1 | A015-C-203 | Human | Colorectum | FAP | 2.96e-05 | -4.51e-02 | -0.1294 |
10444 | ZER1 | A002-C-205 | Human | Colorectum | FAP | 2.89e-04 | -9.88e-02 | -0.1236 |
10444 | ZER1 | A015-C-006 | Human | Colorectum | FAP | 2.47e-02 | 1.48e-02 | -0.0994 |
10444 | ZER1 | A002-C-114 | Human | Colorectum | FAP | 8.08e-03 | -1.14e-01 | -0.1561 |
10444 | ZER1 | A015-C-104 | Human | Colorectum | FAP | 6.12e-06 | -1.08e-01 | -0.1899 |
10444 | ZER1 | A001-C-014 | Human | Colorectum | FAP | 2.83e-02 | -9.96e-02 | 0.0135 |
10444 | ZER1 | A002-C-016 | Human | Colorectum | FAP | 5.62e-04 | -1.64e-01 | 0.0521 |
10444 | ZER1 | A002-C-116 | Human | Colorectum | FAP | 4.75e-08 | -1.43e-01 | -0.0452 |
10444 | ZER1 | A014-C-008 | Human | Colorectum | FAP | 2.78e-02 | -1.91e-01 | -0.191 |
10444 | ZER1 | A018-E-020 | Human | Colorectum | FAP | 1.23e-04 | -2.20e-01 | -0.2034 |
10444 | ZER1 | F034 | Human | Colorectum | FAP | 4.93e-04 | -1.20e-01 | -0.0665 |
10444 | ZER1 | HTA12-25-1 | Human | Pancreas | PDAC | 2.54e-04 | 5.91e-01 | 0.313 |
10444 | ZER1 | HTA12-26-1 | Human | Pancreas | PDAC | 1.39e-07 | 5.71e-01 | 0.3728 |
10444 | ZER1 | HTA12-29-1 | Human | Pancreas | PDAC | 2.46e-20 | 5.90e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:004586210 | Cervix | CC | positive regulation of proteolysis | 95/2311 | 372/18723 | 1.84e-12 | 6.86e-10 | 95 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:190305010 | Cervix | CC | regulation of proteolysis involved in cellular protein catabolic process | 60/2311 | 221/18723 | 1.82e-09 | 1.98e-07 | 60 |
GO:200005810 | Cervix | CC | regulation of ubiquitin-dependent protein catabolic process | 47/2311 | 164/18723 | 1.63e-08 | 1.25e-06 | 47 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:190336410 | Cervix | CC | positive regulation of cellular protein catabolic process | 43/2311 | 155/18723 | 1.80e-07 | 8.28e-06 | 43 |
GO:006113610 | Cervix | CC | regulation of proteasomal protein catabolic process | 48/2311 | 187/18723 | 4.63e-07 | 1.77e-05 | 48 |
GO:003243410 | Cervix | CC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 38/2311 | 134/18723 | 4.99e-07 | 1.88e-05 | 38 |
GO:19030528 | Cervix | CC | positive regulation of proteolysis involved in cellular protein catabolic process | 34/2311 | 133/18723 | 2.28e-05 | 4.01e-04 | 34 |
GO:200006010 | Cervix | CC | positive regulation of ubiquitin-dependent protein catabolic process | 29/2311 | 107/18723 | 2.77e-05 | 4.62e-04 | 29 |
GO:00324369 | Cervix | CC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 25/2311 | 90/18723 | 6.22e-05 | 8.90e-04 | 25 |
GO:19018008 | Cervix | CC | positive regulation of proteasomal protein catabolic process | 29/2311 | 114/18723 | 9.71e-05 | 1.27e-03 | 29 |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZER1 | SNV | Missense_Mutation | c.2129N>C | p.Val710Ala | p.V710A | Q7Z7L7 | protein_coding | tolerated(0.06) | probably_damaging(0.956) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZER1 | SNV | Missense_Mutation | rs773300702 | c.151N>A | p.Val51Ile | p.V51I | Q7Z7L7 | protein_coding | tolerated(0.48) | benign(0.146) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZER1 | SNV | Missense_Mutation | rs370965484 | c.770N>A | p.Arg257His | p.R257H | Q7Z7L7 | protein_coding | tolerated(0.21) | benign(0) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ZER1 | SNV | Missense_Mutation | novel | c.768N>G | p.Asp256Glu | p.D256E | Q7Z7L7 | protein_coding | tolerated(1) | benign(0.001) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ZER1 | SNV | Missense_Mutation | novel | c.986N>C | p.Leu329Pro | p.L329P | Q7Z7L7 | protein_coding | deleterious(0) | possibly_damaging(0.69) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZER1 | SNV | Missense_Mutation | c.1267N>C | p.Asn423His | p.N423H | Q7Z7L7 | protein_coding | tolerated(0.08) | benign(0) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZER1 | SNV | Missense_Mutation | novel | c.927N>G | p.Ile309Met | p.I309M | Q7Z7L7 | protein_coding | tolerated(0.17) | benign(0.201) | TCGA-CC-A8HU-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZER1 | SNV | Missense_Mutation | c.1466C>T | p.Thr489Met | p.T489M | Q7Z7L7 | protein_coding | tolerated(0.13) | benign(0.172) | TCGA-49-AAR2-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | taxol | CR | |
ZER1 | SNV | Missense_Mutation | c.2228N>A | p.Thr743Asn | p.T743N | Q7Z7L7 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
ZER1 | SNV | Missense_Mutation | novel | c.1064N>T | p.Gln355Leu | p.Q355L | Q7Z7L7 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-55-8616-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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