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Gene: ZBTB43 |
Gene summary for ZBTB43 |
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Gene information | Species | Human | Gene symbol | ZBTB43 | Gene ID | 23099 |
Gene name | zinc finger and BTB domain containing 43 | |
Gene Alias | ZBTB22B | |
Cytomap | 9q33.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O43298 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23099 | ZBTB43 | LZE4T | Human | Esophagus | ESCC | 9.32e-19 | 5.53e-01 | 0.0811 |
23099 | ZBTB43 | LZE7T | Human | Esophagus | ESCC | 3.00e-07 | 3.51e-01 | 0.0667 |
23099 | ZBTB43 | LZE8T | Human | Esophagus | ESCC | 5.22e-09 | 2.07e-01 | 0.067 |
23099 | ZBTB43 | LZE20T | Human | Esophagus | ESCC | 1.21e-03 | 3.21e-01 | 0.0662 |
23099 | ZBTB43 | LZE24T | Human | Esophagus | ESCC | 1.28e-07 | 3.15e-01 | 0.0596 |
23099 | ZBTB43 | P1T-E | Human | Esophagus | ESCC | 2.54e-07 | 3.56e-01 | 0.0875 |
23099 | ZBTB43 | P2T-E | Human | Esophagus | ESCC | 3.60e-26 | 4.21e-01 | 0.1177 |
23099 | ZBTB43 | P4T-E | Human | Esophagus | ESCC | 9.28e-10 | 3.75e-01 | 0.1323 |
23099 | ZBTB43 | P5T-E | Human | Esophagus | ESCC | 7.24e-06 | 1.12e-01 | 0.1327 |
23099 | ZBTB43 | P8T-E | Human | Esophagus | ESCC | 3.76e-29 | 6.85e-01 | 0.0889 |
23099 | ZBTB43 | P9T-E | Human | Esophagus | ESCC | 5.14e-11 | 3.09e-01 | 0.1131 |
23099 | ZBTB43 | P10T-E | Human | Esophagus | ESCC | 1.59e-11 | 3.20e-01 | 0.116 |
23099 | ZBTB43 | P11T-E | Human | Esophagus | ESCC | 1.06e-08 | 6.47e-01 | 0.1426 |
23099 | ZBTB43 | P12T-E | Human | Esophagus | ESCC | 3.02e-15 | 2.91e-01 | 0.1122 |
23099 | ZBTB43 | P15T-E | Human | Esophagus | ESCC | 1.78e-13 | 3.96e-01 | 0.1149 |
23099 | ZBTB43 | P16T-E | Human | Esophagus | ESCC | 2.25e-13 | 1.58e-01 | 0.1153 |
23099 | ZBTB43 | P20T-E | Human | Esophagus | ESCC | 3.27e-09 | 2.42e-01 | 0.1124 |
23099 | ZBTB43 | P21T-E | Human | Esophagus | ESCC | 3.69e-16 | 4.14e-01 | 0.1617 |
23099 | ZBTB43 | P22T-E | Human | Esophagus | ESCC | 5.38e-05 | 5.99e-02 | 0.1236 |
23099 | ZBTB43 | P23T-E | Human | Esophagus | ESCC | 1.42e-08 | 2.68e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB43 | SNV | Missense_Mutation | novel | c.532G>C | p.Glu178Gln | p.E178Q | O43298 | protein_coding | tolerated(0.16) | benign(0.272) | TCGA-CV-5444-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZBTB43 | SNV | Missense_Mutation | c.992N>G | p.Asp331Gly | p.D331G | O43298 | protein_coding | tolerated(0.36) | benign(0) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB43 | SNV | Missense_Mutation | c.688C>T | p.Pro230Ser | p.P230S | O43298 | protein_coding | tolerated(0.11) | probably_damaging(0.992) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBTB43 | SNV | Missense_Mutation | rs373620611 | c.133N>T | p.Arg45Trp | p.R45W | O43298 | protein_coding | deleterious(0) | possibly_damaging(0.623) | TCGA-BR-6801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZBTB43 | SNV | Missense_Mutation | c.1280C>T | p.Pro427Leu | p.P427L | O43298 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ZBTB43 | SNV | Missense_Mutation | c.598N>C | p.Ser200Pro | p.S200P | O43298 | protein_coding | tolerated(0.32) | benign(0.014) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZBTB43 | SNV | Missense_Mutation | c.1061N>A | p.Val354Glu | p.V354E | O43298 | protein_coding | tolerated(0.83) | benign(0.014) | TCGA-CG-4443-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB43 | SNV | Missense_Mutation | novel | c.895G>A | p.Glu299Lys | p.E299K | O43298 | protein_coding | tolerated(0.79) | benign(0.05) | TCGA-IM-A41Y-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Hormone Therapy | synthroid | SD |
ZBTB43 | insertion | Nonsense_Mutation | novel | c.453_454insTATAACTAGATAGGAGAAT | p.Val152TyrfsTer3 | p.V152Yfs*3 | O43298 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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