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Gene: XPNPEP3 |
Gene summary for XPNPEP3 |
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Gene information | Species | Human | Gene symbol | XPNPEP3 | Gene ID | 63929 |
Gene name | X-prolyl aminopeptidase 3 | |
Gene Alias | APP3 | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A087X0Z2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63929 | XPNPEP3 | LZE4T | Human | Esophagus | ESCC | 9.15e-05 | 1.42e-01 | 0.0811 |
63929 | XPNPEP3 | LZE7T | Human | Esophagus | ESCC | 8.56e-03 | 2.43e-01 | 0.0667 |
63929 | XPNPEP3 | LZE8T | Human | Esophagus | ESCC | 7.34e-04 | 1.15e-01 | 0.067 |
63929 | XPNPEP3 | LZE20T | Human | Esophagus | ESCC | 7.38e-08 | 1.99e-01 | 0.0662 |
63929 | XPNPEP3 | LZE24T | Human | Esophagus | ESCC | 1.96e-15 | 4.32e-01 | 0.0596 |
63929 | XPNPEP3 | LZE6T | Human | Esophagus | ESCC | 1.02e-04 | 1.94e-01 | 0.0845 |
63929 | XPNPEP3 | P1T-E | Human | Esophagus | ESCC | 1.35e-04 | 2.90e-01 | 0.0875 |
63929 | XPNPEP3 | P2T-E | Human | Esophagus | ESCC | 3.98e-24 | 3.81e-01 | 0.1177 |
63929 | XPNPEP3 | P4T-E | Human | Esophagus | ESCC | 2.56e-17 | 3.28e-01 | 0.1323 |
63929 | XPNPEP3 | P5T-E | Human | Esophagus | ESCC | 4.85e-11 | 2.26e-01 | 0.1327 |
63929 | XPNPEP3 | P8T-E | Human | Esophagus | ESCC | 1.64e-15 | 3.13e-01 | 0.0889 |
63929 | XPNPEP3 | P9T-E | Human | Esophagus | ESCC | 3.49e-11 | 2.37e-01 | 0.1131 |
63929 | XPNPEP3 | P10T-E | Human | Esophagus | ESCC | 3.89e-27 | 4.67e-01 | 0.116 |
63929 | XPNPEP3 | P11T-E | Human | Esophagus | ESCC | 7.35e-06 | 3.22e-01 | 0.1426 |
63929 | XPNPEP3 | P12T-E | Human | Esophagus | ESCC | 2.65e-16 | 3.50e-01 | 0.1122 |
63929 | XPNPEP3 | P15T-E | Human | Esophagus | ESCC | 6.09e-21 | 4.12e-01 | 0.1149 |
63929 | XPNPEP3 | P16T-E | Human | Esophagus | ESCC | 3.81e-24 | 4.78e-01 | 0.1153 |
63929 | XPNPEP3 | P17T-E | Human | Esophagus | ESCC | 6.33e-06 | 1.81e-01 | 0.1278 |
63929 | XPNPEP3 | P19T-E | Human | Esophagus | ESCC | 5.64e-04 | 2.41e-01 | 0.1662 |
63929 | XPNPEP3 | P20T-E | Human | Esophagus | ESCC | 6.00e-19 | 3.44e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:001648511 | Liver | HCC | protein processing | 121/7958 | 225/18723 | 4.01e-04 | 2.71e-03 | 121 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
XPNPEP3 | SNV | Missense_Mutation | novel | c.403G>T | p.Val135Phe | p.V135F | Q9NQH7 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD |
XPNPEP3 | SNV | Missense_Mutation | c.626N>T | p.Pro209Leu | p.P209L | Q9NQH7 | protein_coding | deleterious(0.03) | probably_damaging(0.993) | TCGA-KK-A5A1-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
XPNPEP3 | SNV | Missense_Mutation | c.1514N>G | p.Gln505Arg | p.Q505R | Q9NQH7 | protein_coding | tolerated(1) | benign(0) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
XPNPEP3 | SNV | Missense_Mutation | rs748610440 | c.149G>A | p.Ser50Asn | p.S50N | Q9NQH7 | protein_coding | deleterious(0.03) | probably_damaging(0.94) | TCGA-R5-A7ZI-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
XPNPEP3 | SNV | Missense_Mutation | rs763626716 | c.551C>T | p.Thr184Met | p.T184M | Q9NQH7 | protein_coding | deleterious(0.05) | possibly_damaging(0.657) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
XPNPEP3 | SNV | Missense_Mutation | rs377686555 | c.1129C>T | p.Pro377Ser | p.P377S | Q9NQH7 | protein_coding | tolerated(0.13) | benign(0.24) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
XPNPEP3 | SNV | Missense_Mutation | novel | c.1296C>G | p.Asp432Glu | p.D432E | Q9NQH7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
XPNPEP3 | SNV | Missense_Mutation | novel | c.1211A>C | p.Asn404Thr | p.N404T | Q9NQH7 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
XPNPEP3 | SNV | Missense_Mutation | novel | c.293N>C | p.Val98Ala | p.V98A | Q9NQH7 | protein_coding | deleterious(0) | possibly_damaging(0.478) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
63929 | XPNPEP3 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL2103847 | TOSEDOSTAT |
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