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Gene: WTAP |
Gene summary for WTAP |
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Gene information | Species | Human | Gene symbol | WTAP | Gene ID | 9589 |
Gene name | WT1 associated protein | |
Gene Alias | Mum2 | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | Q15007 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9589 | WTAP | GSM4909285 | Human | Breast | IDC | 4.20e-09 | -4.47e-01 | 0.21 |
9589 | WTAP | GSM4909286 | Human | Breast | IDC | 2.78e-08 | -2.13e-01 | 0.1081 |
9589 | WTAP | GSM4909288 | Human | Breast | IDC | 1.46e-03 | -4.52e-01 | 0.0988 |
9589 | WTAP | GSM4909291 | Human | Breast | IDC | 1.46e-14 | -6.05e-01 | 0.1753 |
9589 | WTAP | GSM4909292 | Human | Breast | IDC | 2.24e-05 | -7.57e-01 | 0.1236 |
9589 | WTAP | GSM4909293 | Human | Breast | IDC | 7.75e-04 | -2.96e-01 | 0.1581 |
9589 | WTAP | GSM4909294 | Human | Breast | IDC | 3.32e-12 | -5.67e-01 | 0.2022 |
9589 | WTAP | GSM4909296 | Human | Breast | IDC | 3.72e-36 | -7.32e-01 | 0.1524 |
9589 | WTAP | GSM4909297 | Human | Breast | IDC | 9.34e-19 | -3.45e-01 | 0.1517 |
9589 | WTAP | GSM4909298 | Human | Breast | IDC | 4.93e-07 | -3.86e-01 | 0.1551 |
9589 | WTAP | GSM4909299 | Human | Breast | IDC | 3.74e-04 | -3.22e-01 | 0.035 |
9589 | WTAP | GSM4909301 | Human | Breast | IDC | 5.13e-08 | -4.64e-01 | 0.1577 |
9589 | WTAP | GSM4909302 | Human | Breast | IDC | 5.26e-25 | -5.93e-01 | 0.1545 |
9589 | WTAP | GSM4909304 | Human | Breast | IDC | 2.32e-06 | -4.15e-01 | 0.1636 |
9589 | WTAP | GSM4909305 | Human | Breast | IDC | 4.28e-02 | -2.33e-01 | 0.0436 |
9589 | WTAP | GSM4909306 | Human | Breast | IDC | 4.09e-10 | -4.35e-01 | 0.1564 |
9589 | WTAP | GSM4909307 | Human | Breast | IDC | 2.37e-17 | -5.72e-01 | 0.1569 |
9589 | WTAP | GSM4909308 | Human | Breast | IDC | 8.16e-11 | -4.18e-01 | 0.158 |
9589 | WTAP | GSM4909309 | Human | Breast | IDC | 1.21e-13 | -4.67e-01 | 0.0483 |
9589 | WTAP | GSM4909311 | Human | Breast | IDC | 1.47e-40 | -7.04e-01 | 0.1534 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:00003759 | Breast | Precancer | RNA splicing, via transesterification reactions | 52/1080 | 324/18723 | 1.74e-11 | 2.22e-09 | 52 |
GO:00003779 | Breast | Precancer | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00003989 | Breast | Precancer | mRNA splicing, via spliceosome | 51/1080 | 320/18723 | 3.55e-11 | 4.04e-09 | 51 |
GO:00480249 | Breast | Precancer | regulation of mRNA splicing, via spliceosome | 22/1080 | 101/18723 | 5.29e-08 | 3.18e-06 | 22 |
GO:19033118 | Breast | Precancer | regulation of mRNA metabolic process | 38/1080 | 288/18723 | 1.63e-06 | 5.97e-05 | 38 |
GO:00506848 | Breast | Precancer | regulation of mRNA processing | 23/1080 | 137/18723 | 3.49e-06 | 1.13e-04 | 23 |
GO:00003808 | Breast | Precancer | alternative mRNA splicing, via spliceosome | 15/1080 | 77/18723 | 2.86e-05 | 6.37e-04 | 15 |
GO:00003818 | Breast | Precancer | regulation of alternative mRNA splicing, via spliceosome | 13/1080 | 60/18723 | 2.98e-05 | 6.58e-04 | 13 |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:004348414 | Breast | IDC | regulation of RNA splicing | 36/1434 | 148/18723 | 3.32e-10 | 3.77e-08 | 36 |
GO:000037514 | Breast | IDC | RNA splicing, via transesterification reactions | 58/1434 | 324/18723 | 9.44e-10 | 9.58e-08 | 58 |
GO:000037714 | Breast | IDC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:000039814 | Breast | IDC | mRNA splicing, via spliceosome | 57/1434 | 320/18723 | 1.60e-09 | 1.49e-07 | 57 |
GO:004802414 | Breast | IDC | regulation of mRNA splicing, via spliceosome | 23/1434 | 101/18723 | 1.74e-06 | 7.28e-05 | 23 |
GO:005068413 | Breast | IDC | regulation of mRNA processing | 24/1434 | 137/18723 | 1.09e-04 | 2.04e-03 | 24 |
GO:190331113 | Breast | IDC | regulation of mRNA metabolic process | 40/1434 | 288/18723 | 1.79e-04 | 3.01e-03 | 40 |
GO:000038113 | Breast | IDC | regulation of alternative mRNA splicing, via spliceosome | 13/1434 | 60/18723 | 5.09e-04 | 6.65e-03 | 13 |
GO:000038013 | Breast | IDC | alternative mRNA splicing, via spliceosome | 15/1434 | 77/18723 | 6.51e-04 | 8.04e-03 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WTAP | SNV | Missense_Mutation | novel | c.1036G>A | p.Glu346Lys | p.E346K | Q15007 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.987) | TCGA-CQ-6221-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WTAP | SNV | Missense_Mutation | rs373161821 | c.985N>A | p.Val329Ile | p.V329I | Q15007 | protein_coding | tolerated_low_confidence(0.93) | benign(0) | TCGA-MT-A67A-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WTAP | SNV | Missense_Mutation | novel | c.731N>G | p.Ser244Cys | p.S244C | Q15007 | protein_coding | tolerated(0.08) | benign(0.303) | TCGA-P3-A6T7-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
WTAP | SNV | Missense_Mutation | c.485G>C | p.Arg162Pro | p.R162P | Q15007 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-KK-A8IA-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | lupron | SD | |
WTAP | SNV | Missense_Mutation | c.211N>T | p.Arg71Cys | p.R71C | Q15007 | protein_coding | deleterious(0.01) | benign(0.057) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
WTAP | SNV | Missense_Mutation | rs747375621 | c.850N>T | p.Arg284Cys | p.R284C | Q15007 | protein_coding | deleterious(0.01) | benign(0.125) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
WTAP | SNV | Missense_Mutation | rs771401662 | c.851N>A | p.Arg284His | p.R284H | Q15007 | protein_coding | tolerated(0.26) | benign(0) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
WTAP | SNV | Missense_Mutation | rs752368470 | c.748A>C | p.Ser250Arg | p.S250R | Q15007 | protein_coding | tolerated(0.18) | benign(0.034) | TCGA-RD-A8NB-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
WTAP | SNV | Missense_Mutation | novel | c.733N>A | p.Gln245Lys | p.Q245K | Q15007 | protein_coding | tolerated(0.42) | benign(0.215) | TCGA-EM-A2CL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WTAP | insertion | Frame_Shift_Ins | novel | c.411_412insTTAC | p.Ala138LeufsTer5 | p.A138Lfs*5 | Q15007 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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