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Gene: WISP1 |
Gene summary for WISP1 |
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Gene information | Species | Human | Gene symbol | WISP1 | Gene ID | 8840 |
Gene name | cellular communication network factor 4 | |
Gene Alias | WISP1 | |
Cytomap | 8q24.22 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | O95388 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8840 | WISP1 | C38 | Human | Oral cavity | OSCC | 3.77e-20 | 1.23e+00 | 0.172 |
8840 | WISP1 | C46 | Human | Oral cavity | OSCC | 1.19e-04 | 1.49e-01 | 0.1673 |
8840 | WISP1 | LN38 | Human | Oral cavity | OSCC | 4.47e-05 | 6.74e-01 | 0.168 |
8840 | WISP1 | LN46 | Human | Oral cavity | OSCC | 9.20e-04 | 2.05e-01 | 0.1666 |
8840 | WISP1 | ATC12 | Human | Thyroid | ATC | 4.82e-02 | 1.00e-01 | 0.34 |
8840 | WISP1 | ATC13 | Human | Thyroid | ATC | 4.82e-02 | 7.86e-02 | 0.34 |
8840 | WISP1 | ATC2 | Human | Thyroid | ATC | 1.60e-07 | 5.69e-01 | 0.34 |
8840 | WISP1 | ATC4 | Human | Thyroid | ATC | 6.21e-03 | 1.20e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WISP1 | SNV | Missense_Mutation | rs201971205 | c.449C>T | p.Ala150Val | p.A150V | O95388 | protein_coding | tolerated(0.06) | possibly_damaging(0.667) | TCGA-05-4382-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
WISP1 | SNV | Missense_Mutation | c.358N>T | p.Gly120Cys | p.G120C | O95388 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-05-5425-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | gefitinib | PD | |
WISP1 | SNV | Missense_Mutation | c.182N>A | p.Arg61His | p.R61H | O95388 | protein_coding | tolerated(0.16) | benign(0.138) | TCGA-49-6767-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WISP1 | SNV | Missense_Mutation | c.677G>T | p.Cys226Phe | p.C226F | O95388 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-55-6970-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
WISP1 | SNV | Missense_Mutation | rs745595165 | c.289C>T | p.Arg97Trp | p.R97W | O95388 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WISP1 | SNV | Missense_Mutation | c.680C>A | p.Ser227Tyr | p.S227Y | O95388 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
WISP1 | SNV | Missense_Mutation | c.778G>T | p.Asp260Tyr | p.D260Y | O95388 | protein_coding | deleterious(0) | possibly_damaging(0.834) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
WISP1 | SNV | Missense_Mutation | novel | c.988T>C | p.Phe330Leu | p.F330L | O95388 | protein_coding | deleterious(0.02) | benign(0.217) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WISP1 | SNV | Missense_Mutation | c.592C>A | p.Arg198Ser | p.R198S | O95388 | protein_coding | tolerated(0.08) | benign(0.145) | TCGA-78-7149-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
WISP1 | SNV | Missense_Mutation | c.79C>A | p.Pro27Thr | p.P27T | O95388 | protein_coding | tolerated(0.06) | benign(0.107) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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