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Gene: VCAN |
Gene summary for VCAN |
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Gene information | Species | Human | Gene symbol | VCAN | Gene ID | 1462 |
Gene name | versican | |
Gene Alias | CSPG2 | |
Cytomap | 5q14.2-q14.3 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P13611 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1462 | VCAN | AEH-subject1 | Human | Endometrium | AEH | 6.82e-04 | -4.39e-01 | -0.3059 |
1462 | VCAN | AEH-subject2 | Human | Endometrium | AEH | 3.70e-19 | -7.02e-01 | -0.2525 |
1462 | VCAN | AEH-subject3 | Human | Endometrium | AEH | 1.97e-08 | -4.97e-01 | -0.2576 |
1462 | VCAN | AEH-subject5 | Human | Endometrium | AEH | 7.03e-13 | -5.88e-01 | -0.2953 |
1462 | VCAN | EEC-subject2 | Human | Endometrium | EEC | 7.87e-17 | -6.81e-01 | -0.2607 |
1462 | VCAN | EEC-subject3 | Human | Endometrium | EEC | 4.38e-11 | -4.27e-01 | -0.2525 |
1462 | VCAN | EEC-subject4 | Human | Endometrium | EEC | 2.31e-16 | -6.39e-01 | -0.2571 |
1462 | VCAN | EEC-subject5 | Human | Endometrium | EEC | 4.33e-15 | -6.61e-01 | -0.249 |
1462 | VCAN | GSM5276935 | Human | Endometrium | EEC | 6.59e-23 | -7.49e-01 | -0.123 |
1462 | VCAN | GSM5276937 | Human | Endometrium | EEC | 1.38e-12 | -6.16e-01 | -0.0897 |
1462 | VCAN | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 2.79e-19 | -6.46e-01 | -0.1869 |
1462 | VCAN | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.53e-14 | -6.49e-01 | -0.1875 |
1462 | VCAN | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.30e-24 | -7.76e-01 | -0.1883 |
1462 | VCAN | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.24e-16 | -5.13e-01 | -0.1917 |
1462 | VCAN | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 7.17e-17 | -5.47e-01 | -0.1916 |
1462 | VCAN | P2T-E | Human | Esophagus | ESCC | 3.81e-16 | 5.16e-01 | 0.1177 |
1462 | VCAN | P4T-E | Human | Esophagus | ESCC | 2.19e-11 | 1.09e+00 | 0.1323 |
1462 | VCAN | P5T-E | Human | Esophagus | ESCC | 1.03e-03 | 9.52e-01 | 0.1327 |
1462 | VCAN | P8T-E | Human | Esophagus | ESCC | 2.81e-11 | 7.96e-01 | 0.0889 |
1462 | VCAN | P9T-E | Human | Esophagus | ESCC | 1.52e-13 | 1.37e+00 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016498 | Endometrium | AEH | osteoblast differentiation | 52/2100 | 229/18723 | 4.74e-07 | 1.92e-05 | 52 |
GO:00015038 | Endometrium | AEH | ossification | 78/2100 | 408/18723 | 1.54e-06 | 4.85e-05 | 78 |
GO:000164914 | Endometrium | EEC | osteoblast differentiation | 53/2168 | 229/18723 | 5.32e-07 | 2.02e-05 | 53 |
GO:000150313 | Endometrium | EEC | ossification | 79/2168 | 408/18723 | 2.72e-06 | 7.67e-05 | 79 |
GO:000164918 | Esophagus | ESCC | osteoblast differentiation | 140/8552 | 229/18723 | 1.63e-06 | 1.95e-05 | 140 |
GO:000150317 | Esophagus | ESCC | ossification | 232/8552 | 408/18723 | 3.00e-06 | 3.40e-05 | 232 |
GO:000150310 | Oral cavity | OSCC | ossification | 203/7305 | 408/18723 | 5.54e-06 | 6.19e-05 | 203 |
GO:000164910 | Oral cavity | OSCC | osteoblast differentiation | 118/7305 | 229/18723 | 7.51e-05 | 5.85e-04 | 118 |
GO:000150331 | Oral cavity | NEOLP | ossification | 81/2005 | 408/18723 | 2.67e-08 | 1.15e-06 | 81 |
GO:000164931 | Oral cavity | NEOLP | osteoblast differentiation | 47/2005 | 229/18723 | 8.59e-06 | 1.66e-04 | 47 |
GO:00016499 | Prostate | BPH | osteoblast differentiation | 75/3107 | 229/18723 | 1.29e-09 | 5.57e-08 | 75 |
GO:00015039 | Prostate | BPH | ossification | 107/3107 | 408/18723 | 4.31e-07 | 8.83e-06 | 107 |
GO:000164915 | Prostate | Tumor | osteoblast differentiation | 77/3246 | 229/18723 | 1.55e-09 | 7.26e-08 | 77 |
GO:000150314 | Prostate | Tumor | ossification | 109/3246 | 408/18723 | 1.13e-06 | 2.14e-05 | 109 |
GO:000164919 | Skin | AK | osteoblast differentiation | 52/1910 | 229/18723 | 2.27e-08 | 1.28e-06 | 52 |
GO:000150318 | Skin | AK | ossification | 78/1910 | 408/18723 | 3.26e-08 | 1.76e-06 | 78 |
GO:0001649110 | Skin | SCCIS | osteoblast differentiation | 34/919 | 229/18723 | 7.78e-09 | 2.95e-06 | 34 |
GO:000150319 | Skin | SCCIS | ossification | 47/919 | 408/18723 | 5.02e-08 | 8.19e-06 | 47 |
GO:000164923 | Skin | cSCC | osteoblast differentiation | 89/4864 | 229/18723 | 1.18e-05 | 1.51e-04 | 89 |
GO:000150323 | Skin | cSCC | ossification | 137/4864 | 408/18723 | 3.39e-04 | 2.68e-03 | 137 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VCAN | SNV | Missense_Mutation | c.641G>C | p.Arg214Thr | p.R214T | P13611 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
VCAN | SNV | Missense_Mutation | rs756870122 | c.5809N>A | p.Asp1937Asn | p.D1937N | P13611 | protein_coding | deleterious(0.01) | possibly_damaging(0.617) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
VCAN | SNV | Missense_Mutation | c.2881N>G | p.Gln961Glu | p.Q961E | P13611 | protein_coding | deleterious(0.03) | benign(0.084) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
VCAN | SNV | Missense_Mutation | c.7360N>A | p.Glu2454Lys | p.E2454K | P13611 | protein_coding | tolerated(0.91) | benign(0.038) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
VCAN | SNV | Missense_Mutation | rs776898982 | c.92N>T | p.Pro31Leu | p.P31L | P13611 | protein_coding | tolerated(0.11) | possibly_damaging(0.501) | TCGA-Q1-A73Q-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
VCAN | SNV | Missense_Mutation | c.3923N>G | p.Ser1308Cys | p.S1308C | P13611 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-ZJ-A8QQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
VCAN | SNV | Missense_Mutation | rs143128206 | c.1063N>C | p.Asp355His | p.D355H | P13611 | protein_coding | deleterious(0) | benign(0.425) | TCGA-ZJ-AAXB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
VCAN | SNV | Missense_Mutation | c.9677N>A | p.Ile3226Lys | p.I3226K | P13611 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
VCAN | SNV | Missense_Mutation | rs867199496 | c.8890G>A | p.Asp2964Asn | p.D2964N | P13611 | protein_coding | tolerated(0.3) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
VCAN | SNV | Missense_Mutation | rs763390705 | c.9941N>A | p.Arg3314His | p.R3314H | P13611 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1462 | VCAN | DRUGGABLE GENOME | CSA | CYCLOSPORINE | 14974815 |
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