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Gene: UTP20 |
Gene summary for UTP20 |
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Gene information | Species | Human | Gene symbol | UTP20 | Gene ID | 27340 |
Gene name | UTP20 small subunit processome component | |
Gene Alias | 1A6/DRIM | |
Cytomap | 12q23.2 | |
Gene Type | protein-coding | GO ID | GO:0000447 | UniProtAcc | O75691 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27340 | UTP20 | LZE4T | Human | Esophagus | ESCC | 2.75e-05 | 1.37e-01 | 0.0811 |
27340 | UTP20 | LZE8T | Human | Esophagus | ESCC | 6.68e-07 | 2.61e-01 | 0.067 |
27340 | UTP20 | LZE24T | Human | Esophagus | ESCC | 8.95e-05 | 8.98e-02 | 0.0596 |
27340 | UTP20 | P1T-E | Human | Esophagus | ESCC | 2.28e-02 | 1.95e-01 | 0.0875 |
27340 | UTP20 | P2T-E | Human | Esophagus | ESCC | 1.10e-28 | 5.20e-01 | 0.1177 |
27340 | UTP20 | P4T-E | Human | Esophagus | ESCC | 1.61e-05 | 2.21e-01 | 0.1323 |
27340 | UTP20 | P5T-E | Human | Esophagus | ESCC | 8.67e-10 | 1.55e-01 | 0.1327 |
27340 | UTP20 | P8T-E | Human | Esophagus | ESCC | 1.63e-13 | 2.73e-01 | 0.0889 |
27340 | UTP20 | P10T-E | Human | Esophagus | ESCC | 8.36e-10 | 1.85e-01 | 0.116 |
27340 | UTP20 | P11T-E | Human | Esophagus | ESCC | 1.47e-05 | 3.04e-01 | 0.1426 |
27340 | UTP20 | P12T-E | Human | Esophagus | ESCC | 8.89e-07 | 1.38e-01 | 0.1122 |
27340 | UTP20 | P15T-E | Human | Esophagus | ESCC | 1.62e-14 | 3.55e-01 | 0.1149 |
27340 | UTP20 | P16T-E | Human | Esophagus | ESCC | 7.12e-21 | 2.93e-01 | 0.1153 |
27340 | UTP20 | P20T-E | Human | Esophagus | ESCC | 5.15e-06 | 2.05e-01 | 0.1124 |
27340 | UTP20 | P21T-E | Human | Esophagus | ESCC | 1.87e-32 | 5.75e-01 | 0.1617 |
27340 | UTP20 | P22T-E | Human | Esophagus | ESCC | 3.89e-13 | 1.76e-01 | 0.1236 |
27340 | UTP20 | P23T-E | Human | Esophagus | ESCC | 2.26e-21 | 2.91e-01 | 0.108 |
27340 | UTP20 | P24T-E | Human | Esophagus | ESCC | 3.18e-08 | 1.20e-01 | 0.1287 |
27340 | UTP20 | P26T-E | Human | Esophagus | ESCC | 2.59e-13 | 2.50e-01 | 0.1276 |
27340 | UTP20 | P27T-E | Human | Esophagus | ESCC | 7.70e-18 | 2.62e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042274111 | Esophagus | ESCC | ribosomal small subunit biogenesis | 67/8552 | 73/18723 | 6.62e-17 | 5.38e-15 | 67 |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00304904 | Esophagus | ESCC | maturation of SSU-rRNA | 45/8552 | 50/18723 | 5.07e-11 | 1.63e-09 | 45 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00004623 | Esophagus | ESCC | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 32/8552 | 37/18723 | 2.96e-07 | 4.23e-06 | 32 |
GO:00004603 | Esophagus | ESCC | maturation of 5.8S rRNA | 30/8552 | 35/18723 | 1.07e-06 | 1.34e-05 | 30 |
GO:00004693 | Esophagus | ESCC | cleavage involved in rRNA processing | 24/8552 | 27/18723 | 3.48e-06 | 3.84e-05 | 24 |
GO:00004663 | Esophagus | ESCC | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 21/8552 | 24/18723 | 2.57e-05 | 2.17e-04 | 21 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
GO:00004783 | Esophagus | ESCC | endonucleolytic cleavage involved in rRNA processing | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00004793 | Esophagus | ESCC | endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:00344713 | Esophagus | ESCC | ncRNA 5'-end processing | 18/8552 | 21/18723 | 1.81e-04 | 1.16e-03 | 18 |
GO:00009663 | Esophagus | ESCC | RNA 5'-end processing | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UTP20 | SNV | Missense_Mutation | novel | c.244N>A | p.Val82Met | p.V82M | O75691 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-6782-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UTP20 | SNV | Missense_Mutation | c.6779C>T | p.Ala2260Val | p.A2260V | O75691 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UTP20 | SNV | Missense_Mutation | c.4981N>A | p.His1661Asn | p.H1661N | O75691 | protein_coding | deleterious(0.02) | benign(0.282) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UTP20 | SNV | Missense_Mutation | c.6397G>A | p.Ala2133Thr | p.A2133T | O75691 | protein_coding | tolerated(0.13) | benign(0.037) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UTP20 | SNV | Missense_Mutation | c.7513N>G | p.Thr2505Ala | p.T2505A | O75691 | protein_coding | tolerated(0.84) | benign(0) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
UTP20 | SNV | Missense_Mutation | c.5144N>T | p.Ala1715Val | p.A1715V | O75691 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
UTP20 | SNV | Missense_Mutation | c.85N>A | p.Asp29Asn | p.D29N | O75691 | protein_coding | tolerated(0.14) | benign(0.434) | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UTP20 | SNV | Missense_Mutation | c.6869N>T | p.Ala2290Val | p.A2290V | O75691 | protein_coding | tolerated(0.05) | benign(0.141) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
UTP20 | SNV | Missense_Mutation | rs779591681 | c.7957N>A | p.Ala2653Thr | p.A2653T | O75691 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
UTP20 | SNV | Missense_Mutation | novel | c.686N>G | p.Phe229Cys | p.F229C | O75691 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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