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Gene: USP54 |
Gene summary for USP54 |
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Gene information | Species | Human | Gene symbol | USP54 | Gene ID | 159195 |
Gene name | ubiquitin specific peptidase 54 | |
Gene Alias | C10orf29 | |
Cytomap | 10q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B7Z7X1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
159195 | USP54 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.42e-03 | -3.15e-01 | 0.0155 |
159195 | USP54 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.37e-03 | -4.16e-01 | -0.0179 |
159195 | USP54 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.74e-10 | -3.43e-01 | 0.294 |
159195 | USP54 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.70e-09 | -4.34e-01 | 0.3005 |
159195 | USP54 | A002-C-010 | Human | Colorectum | FAP | 4.04e-02 | 1.69e-01 | 0.242 |
159195 | USP54 | A015-C-203 | Human | Colorectum | FAP | 1.34e-25 | -1.68e-01 | -0.1294 |
159195 | USP54 | A015-C-204 | Human | Colorectum | FAP | 1.15e-02 | -1.14e-01 | -0.0228 |
159195 | USP54 | A014-C-040 | Human | Colorectum | FAP | 1.14e-02 | -1.38e-01 | -0.1184 |
159195 | USP54 | A002-C-201 | Human | Colorectum | FAP | 2.22e-11 | -5.18e-02 | 0.0324 |
159195 | USP54 | A001-C-119 | Human | Colorectum | FAP | 1.74e-04 | 5.18e-02 | -0.1557 |
159195 | USP54 | A001-C-108 | Human | Colorectum | FAP | 9.11e-15 | -1.19e-01 | -0.0272 |
159195 | USP54 | A002-C-021 | Human | Colorectum | FAP | 4.23e-02 | 3.10e-01 | 0.1171 |
159195 | USP54 | A002-C-205 | Human | Colorectum | FAP | 8.28e-19 | -9.34e-02 | -0.1236 |
159195 | USP54 | A015-C-006 | Human | Colorectum | FAP | 4.18e-16 | -3.45e-01 | -0.0994 |
159195 | USP54 | A015-C-106 | Human | Colorectum | FAP | 3.86e-08 | -1.30e-01 | -0.0511 |
159195 | USP54 | A002-C-114 | Human | Colorectum | FAP | 2.69e-16 | -5.99e-02 | -0.1561 |
159195 | USP54 | A015-C-104 | Human | Colorectum | FAP | 5.98e-27 | -1.58e-01 | -0.1899 |
159195 | USP54 | A001-C-014 | Human | Colorectum | FAP | 4.07e-10 | -1.40e-01 | 0.0135 |
159195 | USP54 | A002-C-016 | Human | Colorectum | FAP | 1.92e-20 | -1.05e-01 | 0.0521 |
159195 | USP54 | A015-C-002 | Human | Colorectum | FAP | 9.95e-11 | -2.22e-01 | -0.0763 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:00165791 | Liver | HCC | protein deubiquitination | 78/7958 | 139/18723 | 8.13e-04 | 4.87e-03 | 78 |
GO:00706465 | Thyroid | PTC | protein modification by small protein removal | 71/5968 | 157/18723 | 3.03e-04 | 2.12e-03 | 71 |
GO:00165794 | Thyroid | PTC | protein deubiquitination | 59/5968 | 139/18723 | 5.50e-03 | 2.50e-02 | 59 |
GO:007064613 | Thyroid | ATC | protein modification by small protein removal | 71/6293 | 157/18723 | 1.59e-03 | 7.99e-03 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP54 | SNV | Missense_Mutation | novel | c.2855N>A | p.Ala952Asp | p.A952D | Q70EL1 | protein_coding | deleterious_low_confidence(0.03) | benign(0.08) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
USP54 | SNV | Missense_Mutation | rs199597128 | c.1970N>A | p.Arg657Gln | p.R657Q | Q70EL1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
USP54 | SNV | Missense_Mutation | novel | c.2204N>C | p.Ile735Thr | p.I735T | Q70EL1 | protein_coding | tolerated(0.16) | benign(0.001) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP54 | SNV | Missense_Mutation | novel | c.1736N>C | p.Lys579Thr | p.K579T | Q70EL1 | protein_coding | tolerated(0.09) | benign(0.055) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP54 | SNV | Missense_Mutation | novel | c.4964N>T | p.Arg1655Ile | p.R1655I | Q70EL1 | protein_coding | deleterious_low_confidence(0) | benign(0.3) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP54 | SNV | Missense_Mutation | rs780205270 | c.1175N>A | p.Arg392Gln | p.R392Q | Q70EL1 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP54 | SNV | Missense_Mutation | c.863N>G | p.Ser288Cys | p.S288C | Q70EL1 | protein_coding | tolerated(0.05) | benign(0.233) | TCGA-AJ-A23M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | unknown | PD | |
USP54 | SNV | Missense_Mutation | novel | c.1180N>T | p.Asp394Tyr | p.D394Y | Q70EL1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP54 | SNV | Missense_Mutation | novel | c.329A>G | p.Glu110Gly | p.E110G | Q70EL1 | protein_coding | deleterious(0.02) | benign(0.19) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP54 | SNV | Missense_Mutation | rs748931999 | c.4657N>T | p.Gly1553Trp | p.G1553W | Q70EL1 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.803) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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