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Gene: UBA6 |
Gene summary for UBA6 |
Gene summary. |
Gene information | Species | Human | Gene symbol | UBA6 | Gene ID | 55236 |
Gene name | ubiquitin like modifier activating enzyme 6 | |
Gene Alias | E1-L2 | |
Cytomap | 4q13.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A024RDB0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55236 | UBA6 | CA_HPV_3 | Human | Cervix | CC | 1.51e-02 | 8.33e-02 | 0.0414 |
55236 | UBA6 | CCI_1 | Human | Cervix | CC | 3.62e-11 | 1.84e+00 | 0.528 |
55236 | UBA6 | CCI_2 | Human | Cervix | CC | 7.99e-10 | 1.21e+00 | 0.5249 |
55236 | UBA6 | CCI_3 | Human | Cervix | CC | 1.00e-02 | 5.15e-01 | 0.516 |
55236 | UBA6 | Tumor | Human | Cervix | CC | 1.03e-16 | 4.45e-01 | 0.1241 |
55236 | UBA6 | sample3 | Human | Cervix | CC | 8.14e-38 | 7.29e-01 | 0.1387 |
55236 | UBA6 | T3 | Human | Cervix | CC | 4.87e-35 | 6.93e-01 | 0.1389 |
55236 | UBA6 | LZE4T | Human | Esophagus | ESCC | 4.31e-17 | 3.12e-01 | 0.0811 |
55236 | UBA6 | LZE5T | Human | Esophagus | ESCC | 1.69e-05 | 6.21e-01 | 0.0514 |
55236 | UBA6 | LZE8T | Human | Esophagus | ESCC | 4.36e-05 | 2.78e-01 | 0.067 |
55236 | UBA6 | LZE20T | Human | Esophagus | ESCC | 1.44e-07 | 1.95e-01 | 0.0662 |
55236 | UBA6 | LZE22D1 | Human | Esophagus | HGIN | 4.93e-02 | 6.39e-02 | 0.0595 |
55236 | UBA6 | LZE24T | Human | Esophagus | ESCC | 3.23e-09 | 2.06e-01 | 0.0596 |
55236 | UBA6 | LZE21T | Human | Esophagus | ESCC | 1.94e-05 | 4.11e-01 | 0.0655 |
55236 | UBA6 | LZE6T | Human | Esophagus | ESCC | 1.62e-03 | 2.32e-01 | 0.0845 |
55236 | UBA6 | P1T-E | Human | Esophagus | ESCC | 3.55e-10 | 3.42e-01 | 0.0875 |
55236 | UBA6 | P2T-E | Human | Esophagus | ESCC | 1.97e-28 | 5.96e-01 | 0.1177 |
55236 | UBA6 | P4T-E | Human | Esophagus | ESCC | 3.52e-15 | 4.33e-01 | 0.1323 |
55236 | UBA6 | P5T-E | Human | Esophagus | ESCC | 1.30e-17 | 3.25e-01 | 0.1327 |
55236 | UBA6 | P8T-E | Human | Esophagus | ESCC | 4.81e-26 | 4.72e-01 | 0.0889 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00609965 | Cervix | CC | dendritic spine development | 28/2311 | 99/18723 | 1.61e-05 | 3.15e-04 | 28 |
GO:00309003 | Cervix | CC | forebrain development | 64/2311 | 379/18723 | 5.53e-03 | 3.19e-02 | 64 |
GO:00215433 | Cervix | CC | pallium development | 32/2311 | 169/18723 | 8.73e-03 | 4.48e-02 | 32 |
GO:00215436 | Esophagus | ESCC | pallium development | 94/8552 | 169/18723 | 5.79e-03 | 2.14e-02 | 94 |
GO:001635816 | Esophagus | ESCC | dendrite development | 130/8552 | 243/18723 | 8.33e-03 | 2.95e-02 | 130 |
GO:00163585 | Liver | NAFLD | dendrite development | 43/1882 | 243/18723 | 1.70e-04 | 3.07e-03 | 43 |
GO:00609963 | Liver | NAFLD | dendritic spine development | 21/1882 | 99/18723 | 7.26e-04 | 9.27e-03 | 21 |
GO:006099611 | Liver | HCC | dendritic spine development | 54/7958 | 99/18723 | 1.03e-02 | 3.86e-02 | 54 |
GO:001635811 | Liver | HCC | dendrite development | 121/7958 | 243/18723 | 1.26e-02 | 4.56e-02 | 121 |
GO:00163586 | Lung | IAC | dendrite development | 55/2061 | 243/18723 | 1.35e-07 | 1.18e-05 | 55 |
GO:00609964 | Lung | IAC | dendritic spine development | 25/2061 | 99/18723 | 5.18e-05 | 1.18e-03 | 25 |
GO:00215432 | Lung | IAC | pallium development | 33/2061 | 169/18723 | 7.51e-04 | 9.82e-03 | 33 |
GO:00309002 | Lung | IAC | forebrain development | 61/2061 | 379/18723 | 1.52e-03 | 1.61e-02 | 61 |
GO:001635812 | Lung | AIS | dendrite development | 49/1849 | 243/18723 | 9.53e-07 | 6.69e-05 | 49 |
GO:006099612 | Lung | AIS | dendritic spine development | 23/1849 | 99/18723 | 7.62e-05 | 1.95e-03 | 23 |
GO:0007626 | Lung | AIS | locomotory behavior | 31/1849 | 179/18723 | 1.39e-03 | 1.70e-02 | 31 |
GO:003090011 | Lung | AIS | forebrain development | 55/1849 | 379/18723 | 2.37e-03 | 2.48e-02 | 55 |
GO:001635810 | Oral cavity | OSCC | dendrite development | 113/7305 | 243/18723 | 1.00e-02 | 3.49e-02 | 113 |
GO:00215435 | Oral cavity | OSCC | pallium development | 81/7305 | 169/18723 | 1.11e-02 | 3.76e-02 | 81 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0412014 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0412015 | Cervix | CC | Ubiquitin mediated proteolysis | 49/1267 | 142/8465 | 4.26e-09 | 7.68e-08 | 4.54e-08 | 49 |
hsa0412026 | Esophagus | HGIN | Ubiquitin mediated proteolysis | 49/1383 | 142/8465 | 7.78e-08 | 1.33e-06 | 1.06e-06 | 49 |
hsa04120111 | Esophagus | HGIN | Ubiquitin mediated proteolysis | 49/1383 | 142/8465 | 7.78e-08 | 1.33e-06 | 1.06e-06 | 49 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0412010 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412011 | Liver | NAFLD | Ubiquitin mediated proteolysis | 44/1043 | 142/8465 | 2.59e-09 | 1.70e-07 | 1.37e-07 | 44 |
hsa0412041 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412051 | Liver | HCC | Ubiquitin mediated proteolysis | 110/4020 | 142/8465 | 1.67e-13 | 3.74e-12 | 2.08e-12 | 110 |
hsa0412012 | Lung | IAC | Ubiquitin mediated proteolysis | 40/1053 | 142/8465 | 3.24e-07 | 1.76e-05 | 1.17e-05 | 40 |
hsa0412013 | Lung | IAC | Ubiquitin mediated proteolysis | 40/1053 | 142/8465 | 3.24e-07 | 1.76e-05 | 1.17e-05 | 40 |
hsa0412022 | Lung | AIS | Ubiquitin mediated proteolysis | 41/961 | 142/8465 | 8.01e-09 | 4.33e-07 | 2.77e-07 | 41 |
hsa0412032 | Lung | AIS | Ubiquitin mediated proteolysis | 41/961 | 142/8465 | 8.01e-09 | 4.33e-07 | 2.77e-07 | 41 |
hsa0412020 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa04120110 | Oral cavity | OSCC | Ubiquitin mediated proteolysis | 105/3704 | 142/8465 | 1.83e-13 | 4.37e-12 | 2.23e-12 | 105 |
hsa0412025 | Oral cavity | LP | Ubiquitin mediated proteolysis | 66/2418 | 142/8465 | 3.74e-06 | 3.46e-05 | 2.23e-05 | 66 |
hsa0412035 | Oral cavity | LP | Ubiquitin mediated proteolysis | 66/2418 | 142/8465 | 3.74e-06 | 3.46e-05 | 2.23e-05 | 66 |
hsa0412043 | Oral cavity | EOLP | Ubiquitin mediated proteolysis | 48/1218 | 142/8465 | 3.55e-09 | 6.74e-08 | 3.98e-08 | 48 |
hsa0412053 | Oral cavity | EOLP | Ubiquitin mediated proteolysis | 48/1218 | 142/8465 | 3.55e-09 | 6.74e-08 | 3.98e-08 | 48 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBA6 | SNV | Missense_Mutation | novel | c.1799N>T | p.Thr600Ile | p.T600I | A0AVT1 | protein_coding | tolerated(0.12) | benign(0.289) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBA6 | SNV | Missense_Mutation | c.1601N>A | p.Ser534Tyr | p.S534Y | A0AVT1 | protein_coding | deleterious(0) | benign(0.015) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
UBA6 | SNV | Missense_Mutation | c.2855N>G | p.Phe952Cys | p.F952C | A0AVT1 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-B5-A0K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
UBA6 | SNV | Missense_Mutation | c.2583C>A | p.Phe861Leu | p.F861L | A0AVT1 | protein_coding | deleterious(0) | possibly_damaging(0.617) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UBA6 | SNV | Missense_Mutation | c.842C>A | p.Pro281Gln | p.P281Q | A0AVT1 | protein_coding | tolerated(0.19) | benign(0.05) | TCGA-B5-A11R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
UBA6 | SNV | Missense_Mutation | rs375871246 | c.2653C>T | p.Arg885Cys | p.R885C | A0AVT1 | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBA6 | SNV | Missense_Mutation | rs745441398 | c.1433N>T | p.Asn478Ile | p.N478I | A0AVT1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBA6 | SNV | Missense_Mutation | novel | c.17N>A | p.Pro6His | p.P6H | A0AVT1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.043) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
UBA6 | SNV | Missense_Mutation | rs771855418 | c.2606N>A | p.Arg869His | p.R869H | A0AVT1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BS-A0TJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UBA6 | SNV | Missense_Mutation | c.2245T>G | p.Leu749Val | p.L749V | A0AVT1 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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