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Gene: TTLL12 |
Gene summary for TTLL12 |
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Gene information | Species | Human | Gene symbol | TTLL12 | Gene ID | 23170 |
Gene name | tubulin tyrosine ligase like 12 | |
Gene Alias | dJ526I14.2 | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A024R4U3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23170 | TTLL12 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.53e-03 | 1.61e-01 | 0.0155 |
23170 | TTLL12 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.11e-07 | 4.13e-01 | -0.1808 |
23170 | TTLL12 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.13e-17 | 6.91e-01 | -0.0811 |
23170 | TTLL12 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.36e-05 | 3.56e-01 | -0.1088 |
23170 | TTLL12 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.37e-24 | 6.32e-01 | -0.1954 |
23170 | TTLL12 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.29e-05 | 8.59e-01 | -0.2602 |
23170 | TTLL12 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.12e-06 | 6.33e-01 | -0.2196 |
23170 | TTLL12 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.61e-09 | 5.70e-01 | -0.1207 |
23170 | TTLL12 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.44e-17 | 8.03e-01 | -0.1526 |
23170 | TTLL12 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.57e-15 | 5.66e-01 | -0.1464 |
23170 | TTLL12 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.29e-09 | 3.93e-01 | -0.1001 |
23170 | TTLL12 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.65e-19 | 7.31e-01 | -0.059 |
23170 | TTLL12 | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.61e-06 | 6.41e-01 | -0.1706 |
23170 | TTLL12 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.58e-04 | 5.27e-01 | -0.2061 |
23170 | TTLL12 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.44e-08 | 5.63e-01 | -0.0842 |
23170 | TTLL12 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.12e-13 | 4.04e-01 | 0.096 |
23170 | TTLL12 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.73e-02 | 3.86e-01 | 0.0451 |
23170 | TTLL12 | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.78e-04 | 6.82e-01 | 0.0171 |
23170 | TTLL12 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.36e-19 | 4.90e-01 | 0.0674 |
23170 | TTLL12 | HTA11_7469_2000001011 | Human | Colorectum | AD | 6.40e-06 | 8.32e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034340 | Colorectum | AD | response to type I interferon | 22/3918 | 58/18723 | 2.23e-03 | 1.75e-02 | 22 |
GO:0060337 | Colorectum | AD | type I interferon signaling pathway | 19/3918 | 50/18723 | 4.23e-03 | 2.91e-02 | 19 |
GO:0007346 | Colorectum | AD | regulation of mitotic cell cycle | 119/3918 | 457/18723 | 4.60e-03 | 3.14e-02 | 119 |
GO:0071357 | Colorectum | AD | cellular response to type I interferon | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
GO:00343401 | Colorectum | SER | response to type I interferon | 17/2897 | 58/18723 | 5.50e-03 | 4.07e-02 | 17 |
GO:00343402 | Colorectum | MSS | response to type I interferon | 20/3467 | 58/18723 | 2.82e-03 | 2.20e-02 | 20 |
GO:00073461 | Colorectum | MSS | regulation of mitotic cell cycle | 108/3467 | 457/18723 | 3.30e-03 | 2.50e-02 | 108 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:003434013 | Esophagus | ESCC | response to type I interferon | 48/8552 | 58/18723 | 6.18e-09 | 1.26e-07 | 48 |
GO:00603375 | Esophagus | ESCC | type I interferon signaling pathway | 41/8552 | 50/18723 | 1.35e-07 | 2.17e-06 | 41 |
GO:00713575 | Esophagus | ESCC | cellular response to type I interferon | 42/8552 | 52/18723 | 2.15e-07 | 3.30e-06 | 42 |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:00607595 | Esophagus | ESCC | regulation of response to cytokine stimulus | 103/8552 | 162/18723 | 3.14e-06 | 3.53e-05 | 103 |
GO:000283212 | Esophagus | ESCC | negative regulation of response to biotic stimulus | 72/8552 | 108/18723 | 8.36e-06 | 8.11e-05 | 72 |
GO:00019595 | Esophagus | ESCC | regulation of cytokine-mediated signaling pathway | 95/8552 | 150/18723 | 9.48e-06 | 9.04e-05 | 95 |
GO:00603385 | Esophagus | ESCC | regulation of type I interferon-mediated signaling pathway | 29/8552 | 36/18723 | 1.91e-05 | 1.67e-04 | 29 |
GO:00450885 | Esophagus | ESCC | regulation of innate immune response | 125/8552 | 218/18723 | 3.34e-04 | 1.96e-03 | 125 |
GO:00507775 | Esophagus | ESCC | negative regulation of immune response | 112/8552 | 194/18723 | 4.67e-04 | 2.62e-03 | 112 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:00458245 | Esophagus | ESCC | negative regulation of innate immune response | 45/8552 | 71/18723 | 1.98e-03 | 8.90e-03 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTLL12 | SNV | Missense_Mutation | novel | c.251N>T | p.Arg84Leu | p.R84L | Q14166 | protein_coding | tolerated(0.28) | benign(0.024) | TCGA-77-6845-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TTLL12 | SNV | Missense_Mutation | novel | c.734N>A | p.Gly245Glu | p.G245E | Q14166 | protein_coding | tolerated(0.05) | benign(0.127) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TTLL12 | SNV | Missense_Mutation | novel | c.758N>G | p.Lys253Arg | p.K253R | Q14166 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-BA-5555-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TTLL12 | SNV | Missense_Mutation | novel | c.1237N>T | p.Asp413Tyr | p.D413Y | Q14166 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-CV-6959-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
TTLL12 | SNV | Missense_Mutation | novel | c.459C>G | p.Phe153Leu | p.F153L | Q14166 | protein_coding | tolerated(0.26) | benign(0.014) | TCGA-MT-A67F-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TTLL12 | insertion | Frame_Shift_Ins | rs34872708 | c.342dupC | p.Asn115GlnfsTer38 | p.N115Qfs*38 | Q14166 | protein_coding | TCGA-EJ-7315-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | ||
TTLL12 | SNV | Missense_Mutation | novel | c.683N>A | p.Pro228His | p.P228H | Q14166 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
TTLL12 | SNV | Missense_Mutation | rs755433997 | c.1325N>A | p.Arg442Gln | p.R442Q | Q14166 | protein_coding | tolerated(0.2) | benign(0.283) | TCGA-BR-8059-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TTLL12 | SNV | Missense_Mutation | rs774841476 | c.1274N>A | p.Arg425His | p.R425H | Q14166 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTLL12 | SNV | Missense_Mutation | rs751449431 | c.379N>T | p.Arg127Cys | p.R127C | Q14166 | protein_coding | deleterious(0) | possibly_damaging(0.88) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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