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Gene: TTC39A |
Gene summary for TTC39A |
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Gene information | Species | Human | Gene symbol | TTC39A | Gene ID | 22996 |
Gene name | tetratricopeptide repeat domain 39A | |
Gene Alias | C1orf34 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A140VJY6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22996 | TTC39A | GSM4909281 | Human | Breast | IDC | 3.76e-07 | 2.32e-01 | 0.21 |
22996 | TTC39A | GSM4909293 | Human | Breast | IDC | 3.32e-02 | 1.73e-01 | 0.1581 |
22996 | TTC39A | GSM4909298 | Human | Breast | IDC | 1.91e-17 | 3.90e-01 | 0.1551 |
22996 | TTC39A | GSM4909303 | Human | Breast | IDC | 3.99e-05 | 3.99e-01 | 0.0438 |
22996 | TTC39A | GSM4909304 | Human | Breast | IDC | 3.71e-03 | 1.90e-01 | 0.1636 |
22996 | TTC39A | GSM4909305 | Human | Breast | IDC | 7.99e-03 | 2.34e-01 | 0.0436 |
22996 | TTC39A | GSM4909306 | Human | Breast | IDC | 1.54e-05 | 2.93e-01 | 0.1564 |
22996 | TTC39A | GSM4909312 | Human | Breast | IDC | 6.60e-08 | 3.88e-01 | 0.1552 |
22996 | TTC39A | GSM4909317 | Human | Breast | IDC | 2.03e-05 | 2.51e-01 | 0.1355 |
22996 | TTC39A | brca2 | Human | Breast | Precancer | 1.38e-10 | 2.53e-01 | -0.024 |
22996 | TTC39A | NCCBC11 | Human | Breast | DCIS | 1.03e-05 | 5.53e-01 | 0.1232 |
22996 | TTC39A | DCIS2 | Human | Breast | DCIS | 3.20e-02 | -4.23e-02 | 0.0085 |
22996 | TTC39A | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.14e-06 | 5.01e-01 | -0.1808 |
22996 | TTC39A | HTA11_78_2000001011 | Human | Colorectum | AD | 9.15e-03 | 3.18e-01 | -0.1088 |
22996 | TTC39A | HTA11_347_2000001011 | Human | Colorectum | AD | 5.71e-17 | 5.97e-01 | -0.1954 |
22996 | TTC39A | HTA11_411_2000001011 | Human | Colorectum | SER | 3.14e-03 | 6.87e-01 | -0.2602 |
22996 | TTC39A | HTA11_2112_2000001011 | Human | Colorectum | SER | 9.81e-03 | 8.09e-01 | -0.2196 |
22996 | TTC39A | HTA11_696_2000001011 | Human | Colorectum | AD | 1.90e-06 | 4.94e-01 | -0.1464 |
22996 | TTC39A | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.16e-04 | 3.57e-01 | -0.059 |
22996 | TTC39A | A002-C-201 | Human | Colorectum | FAP | 7.36e-03 | -1.83e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC39A | SNV | Missense_Mutation | rs746713380 | c.1355N>T | p.Ser452Leu | p.S452L | Q5SRH9 | protein_coding | tolerated(0.07) | benign(0.227) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TTC39A | SNV | Missense_Mutation | c.1493N>G | p.Glu498Gly | p.E498G | Q5SRH9 | protein_coding | deleterious(0.01) | benign(0.366) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TTC39A | SNV | Missense_Mutation | c.686N>T | p.Ala229Val | p.A229V | Q5SRH9 | protein_coding | deleterious(0.01) | possibly_damaging(0.627) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TTC39A | SNV | Missense_Mutation | rs373776775 | c.1114N>C | p.Ser372Pro | p.S372P | Q5SRH9 | protein_coding | deleterious(0) | possibly_damaging(0.555) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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