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Gene: TRRAP |
Gene summary for TRRAP |
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Gene information | Species | Human | Gene symbol | TRRAP | Gene ID | 8295 |
Gene name | transformation/transcription domain associated protein | |
Gene Alias | DEDDFA | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y4A5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8295 | TRRAP | CCI_1 | Human | Cervix | CC | 7.12e-08 | 8.76e-01 | 0.528 |
8295 | TRRAP | CCI_2 | Human | Cervix | CC | 1.10e-06 | 6.56e-01 | 0.5249 |
8295 | TRRAP | CCI_3 | Human | Cervix | CC | 3.68e-07 | 6.56e-01 | 0.516 |
8295 | TRRAP | LZE5T | Human | Esophagus | ESCC | 1.35e-03 | 2.30e-01 | 0.0514 |
8295 | TRRAP | LZE7T | Human | Esophagus | ESCC | 1.28e-08 | 3.46e-01 | 0.0667 |
8295 | TRRAP | LZE24T | Human | Esophagus | ESCC | 1.17e-09 | 2.96e-01 | 0.0596 |
8295 | TRRAP | LZE21T | Human | Esophagus | ESCC | 1.81e-02 | 2.09e-01 | 0.0655 |
8295 | TRRAP | LZE6T | Human | Esophagus | ESCC | 8.69e-03 | 1.67e-01 | 0.0845 |
8295 | TRRAP | P1T-E | Human | Esophagus | ESCC | 2.93e-05 | 2.74e-01 | 0.0875 |
8295 | TRRAP | P2T-E | Human | Esophagus | ESCC | 2.39e-24 | 3.62e-01 | 0.1177 |
8295 | TRRAP | P4T-E | Human | Esophagus | ESCC | 5.42e-15 | 2.89e-01 | 0.1323 |
8295 | TRRAP | P5T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.18e-01 | 0.1327 |
8295 | TRRAP | P8T-E | Human | Esophagus | ESCC | 5.00e-17 | 2.66e-01 | 0.0889 |
8295 | TRRAP | P9T-E | Human | Esophagus | ESCC | 1.57e-11 | 1.81e-01 | 0.1131 |
8295 | TRRAP | P10T-E | Human | Esophagus | ESCC | 2.56e-16 | 2.87e-01 | 0.116 |
8295 | TRRAP | P11T-E | Human | Esophagus | ESCC | 1.75e-07 | 2.87e-01 | 0.1426 |
8295 | TRRAP | P12T-E | Human | Esophagus | ESCC | 8.73e-28 | 4.88e-01 | 0.1122 |
8295 | TRRAP | P15T-E | Human | Esophagus | ESCC | 4.89e-23 | 4.87e-01 | 0.1149 |
8295 | TRRAP | P16T-E | Human | Esophagus | ESCC | 6.54e-32 | 5.81e-01 | 0.1153 |
8295 | TRRAP | P17T-E | Human | Esophagus | ESCC | 1.51e-02 | 2.32e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00165705 | Cervix | CC | histone modification | 84/2311 | 463/18723 | 1.70e-04 | 2.01e-03 | 84 |
GO:00182054 | Cervix | CC | peptidyl-lysine modification | 62/2311 | 376/18723 | 1.04e-02 | 4.97e-02 | 62 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:004396712 | Esophagus | ESCC | histone H4 acetylation | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:007064612 | Esophagus | ESCC | protein modification by small protein removal | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00439682 | Esophagus | ESCC | histone H2A acetylation | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:00165783 | Esophagus | ESCC | histone deubiquitination | 18/8552 | 23/18723 | 1.50e-03 | 7.06e-03 | 18 |
GO:00165793 | Esophagus | ESCC | protein deubiquitination | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:00165703 | Liver | NAFLD | histone modification | 90/1882 | 463/18723 | 5.74e-10 | 1.28e-07 | 90 |
GO:0018205 | Liver | NAFLD | peptidyl-lysine modification | 65/1882 | 376/18723 | 9.42e-06 | 3.02e-04 | 65 |
GO:0043543 | Liver | NAFLD | protein acylation | 43/1882 | 243/18723 | 1.70e-04 | 3.07e-03 | 43 |
GO:0006473 | Liver | NAFLD | protein acetylation | 37/1882 | 201/18723 | 2.10e-04 | 3.61e-03 | 37 |
GO:0018394 | Liver | NAFLD | peptidyl-lysine acetylation | 32/1882 | 169/18723 | 3.24e-04 | 5.00e-03 | 32 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516620 | Cervix | CC | Human T-cell leukemia virus 1 infection | 61/1267 | 222/8465 | 8.13e-07 | 7.98e-06 | 4.72e-06 | 61 |
hsa05166110 | Cervix | CC | Human T-cell leukemia virus 1 infection | 61/1267 | 222/8465 | 8.13e-07 | 7.98e-06 | 4.72e-06 | 61 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0516614 | Liver | Cirrhotic | Human T-cell leukemia virus 1 infection | 87/2530 | 222/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 87 |
hsa0516615 | Liver | Cirrhotic | Human T-cell leukemia virus 1 infection | 87/2530 | 222/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 87 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa0516616 | Lung | IAC | Human T-cell leukemia virus 1 infection | 49/1053 | 222/8465 | 3.44e-05 | 6.38e-04 | 4.24e-04 | 49 |
hsa0516617 | Lung | IAC | Human T-cell leukemia virus 1 infection | 49/1053 | 222/8465 | 3.44e-05 | 6.38e-04 | 4.24e-04 | 49 |
hsa0516623 | Lung | AIS | Human T-cell leukemia virus 1 infection | 45/961 | 222/8465 | 6.69e-05 | 9.43e-04 | 6.03e-04 | 45 |
hsa0516633 | Lung | AIS | Human T-cell leukemia virus 1 infection | 45/961 | 222/8465 | 6.69e-05 | 9.43e-04 | 6.03e-04 | 45 |
hsa0516661 | Lung | MIAC | Human T-cell leukemia virus 1 infection | 23/507 | 222/8465 | 7.02e-03 | 4.44e-02 | 3.21e-02 | 23 |
hsa0516671 | Lung | MIAC | Human T-cell leukemia virus 1 infection | 23/507 | 222/8465 | 7.02e-03 | 4.44e-02 | 3.21e-02 | 23 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRRAP | SNV | Missense_Mutation | c.3819G>T | p.Lys1273Asn | p.K1273N | Q9Y4A5 | protein_coding | deleterious(0.02) | possibly_damaging(0.796) | TCGA-EK-A2RL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | taxol | PD | |
TRRAP | SNV | Missense_Mutation | rs537483764 | c.8851N>A | p.Ala2951Thr | p.A2951T | Q9Y4A5 | protein_coding | tolerated(0.88) | benign(0.111) | TCGA-IR-A3LF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRRAP | SNV | Missense_Mutation | novel | c.1069N>A | p.Glu357Lys | p.E357K | Q9Y4A5 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRRAP | SNV | Missense_Mutation | c.10147N>C | p.Glu3383Gln | p.E3383Q | Q9Y4A5 | protein_coding | tolerated(0.1) | possibly_damaging(0.462) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
TRRAP | SNV | Missense_Mutation | c.9188N>A | p.Arg3063Gln | p.R3063Q | Q9Y4A5 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-JW-A5VH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
TRRAP | SNV | Missense_Mutation | novel | c.5545N>A | p.Asp1849Asn | p.D1849N | Q9Y4A5 | protein_coding | deleterious(0.04) | probably_damaging(0.955) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRRAP | SNV | Missense_Mutation | c.379G>C | p.Glu127Gln | p.E127Q | Q9Y4A5 | protein_coding | deleterious(0.04) | probably_damaging(0.932) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRRAP | SNV | Missense_Mutation | rs782438362 | c.5041N>T | p.Arg1681Cys | p.R1681C | Q9Y4A5 | protein_coding | tolerated(0.12) | possibly_damaging(0.706) | TCGA-R2-A69V-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TRRAP | SNV | Missense_Mutation | novel | c.11507A>C | p.Asn3836Thr | p.N3836T | Q9Y4A5 | protein_coding | tolerated(0.18) | benign(0.07) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRRAP | SNV | Missense_Mutation | c.5623N>A | p.Val1875Met | p.V1875M | Q9Y4A5 | protein_coding | deleterious(0.04) | possibly_damaging(0.557) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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