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Gene: TRIM69 |
Gene summary for TRIM69 |
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Gene information | Species | Human | Gene symbol | TRIM69 | Gene ID | 140691 |
Gene name | tripartite motif containing 69 | |
Gene Alias | HSD-34 | |
Cytomap | 15q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q86WT6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140691 | TRIM69 | LZE4T | Human | Esophagus | ESCC | 6.96e-08 | 2.80e-01 | 0.0811 |
140691 | TRIM69 | LZE7T | Human | Esophagus | ESCC | 6.56e-05 | 2.56e-01 | 0.0667 |
140691 | TRIM69 | LZE8T | Human | Esophagus | ESCC | 1.23e-08 | 3.09e-01 | 0.067 |
140691 | TRIM69 | LZE20T | Human | Esophagus | ESCC | 1.29e-07 | 1.80e-01 | 0.0662 |
140691 | TRIM69 | LZE22T | Human | Esophagus | ESCC | 1.43e-02 | 2.23e-01 | 0.068 |
140691 | TRIM69 | LZE24T | Human | Esophagus | ESCC | 1.46e-24 | 7.04e-01 | 0.0596 |
140691 | TRIM69 | LZE6T | Human | Esophagus | ESCC | 1.00e-12 | 3.96e-01 | 0.0845 |
140691 | TRIM69 | P1T-E | Human | Esophagus | ESCC | 3.53e-14 | 5.57e-01 | 0.0875 |
140691 | TRIM69 | P2T-E | Human | Esophagus | ESCC | 9.89e-30 | 5.33e-01 | 0.1177 |
140691 | TRIM69 | P4T-E | Human | Esophagus | ESCC | 1.69e-21 | 5.52e-01 | 0.1323 |
140691 | TRIM69 | P5T-E | Human | Esophagus | ESCC | 8.07e-25 | 4.85e-01 | 0.1327 |
140691 | TRIM69 | P8T-E | Human | Esophagus | ESCC | 4.98e-27 | 4.56e-01 | 0.0889 |
140691 | TRIM69 | P9T-E | Human | Esophagus | ESCC | 1.01e-54 | 1.14e+00 | 0.1131 |
140691 | TRIM69 | P10T-E | Human | Esophagus | ESCC | 3.80e-09 | 2.27e-01 | 0.116 |
140691 | TRIM69 | P11T-E | Human | Esophagus | ESCC | 8.65e-20 | 6.99e-01 | 0.1426 |
140691 | TRIM69 | P12T-E | Human | Esophagus | ESCC | 1.82e-17 | 4.06e-01 | 0.1122 |
140691 | TRIM69 | P15T-E | Human | Esophagus | ESCC | 6.54e-16 | 4.67e-01 | 0.1149 |
140691 | TRIM69 | P16T-E | Human | Esophagus | ESCC | 9.57e-08 | 1.64e-01 | 0.1153 |
140691 | TRIM69 | P17T-E | Human | Esophagus | ESCC | 1.09e-07 | 5.07e-01 | 0.1278 |
140691 | TRIM69 | P19T-E | Human | Esophagus | ESCC | 7.55e-12 | 4.63e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM69 | SNV | Missense_Mutation | c.1264A>T | p.Thr422Ser | p.T422S | Q86WT6 | protein_coding | tolerated(0.27) | benign(0.165) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TRIM69 | SNV | Missense_Mutation | novel | c.1296C>A | p.Phe432Leu | p.F432L | Q86WT6 | protein_coding | tolerated(0.66) | benign(0.034) | TCGA-49-AARE-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
TRIM69 | SNV | Missense_Mutation | c.1282G>A | p.Asp428Asn | p.D428N | Q86WT6 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-MP-A4SY-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TRIM69 | SNV | Missense_Mutation | novel | c.1399N>G | p.Thr467Ala | p.T467A | Q86WT6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-58-8393-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRIM69 | SNV | Missense_Mutation | c.195N>G | p.Ile65Met | p.I65M | Q86WT6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-66-2773-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRIM69 | SNV | Missense_Mutation | novel | c.157N>G | p.Met53Val | p.M53V | Q86WT6 | protein_coding | tolerated(0.13) | possibly_damaging(0.718) | TCGA-CN-5365-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TRIM69 | SNV | Missense_Mutation | novel | c.211N>A | p.Leu71Met | p.L71M | Q86WT6 | protein_coding | tolerated(0.11) | benign(0.02) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TRIM69 | SNV | Missense_Mutation | rs202081848 | c.1112N>A | p.Arg371Lys | p.R371K | Q86WT6 | protein_coding | tolerated(0.78) | benign(0) | TCGA-HC-A9TE-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | eligard | SD |
TRIM69 | SNV | Missense_Mutation | c.35N>G | p.Asp12Gly | p.D12G | Q86WT6 | protein_coding | deleterious_low_confidence(0.03) | benign(0.115) | TCGA-BR-8291-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | |
TRIM69 | SNV | Missense_Mutation | c.598C>A | p.Gln200Lys | p.Q200K | Q86WT6 | protein_coding | tolerated(0.32) | benign(0.04) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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