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Gene: TRIM58 |
Gene summary for TRIM58 |
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Gene information | Species | Human | Gene symbol | TRIM58 | Gene ID | 25893 |
Gene name | tripartite motif containing 58 | |
Gene Alias | BIA2 | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q8NG06 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25893 | TRIM58 | HCC1 | Human | Liver | HCC | 8.89e-29 | 2.27e+00 | 0.5336 |
25893 | TRIM58 | HCC2 | Human | Liver | HCC | 1.36e-48 | 3.15e+00 | 0.5341 |
25893 | TRIM58 | HCC5 | Human | Liver | HCC | 1.90e-56 | 2.78e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM58 | SNV | Missense_Mutation | rs749839474 | c.607N>T | p.Arg203Trp | p.R203W | Q8NG06 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-EY-A1H0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
TRIM58 | insertion | Nonsense_Mutation | novel | c.1181_1182insAGAAACTTAGGAAA | p.Leu395GlufsTer3 | p.L395Efs*3 | Q8NG06 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRIM58 | insertion | Frame_Shift_Ins | novel | c.1183_1184insA | p.Leu395HisfsTer24 | p.L395Hfs*24 | Q8NG06 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRIM58 | SNV | Missense_Mutation | c.1060N>A | p.Glu354Lys | p.E354K | Q8NG06 | protein_coding | tolerated(0.07) | benign(0.007) | TCGA-CC-A3M9-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
TRIM58 | SNV | Missense_Mutation | c.502A>G | p.Thr168Ala | p.T168A | Q8NG06 | protein_coding | tolerated(0.21) | benign(0.028) | TCGA-CC-A7IF-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
TRIM58 | SNV | Missense_Mutation | novel | c.1124N>A | p.Pro375Gln | p.P375Q | Q8NG06 | protein_coding | tolerated(0.33) | benign(0.348) | TCGA-DD-AADL-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM58 | SNV | Missense_Mutation | c.899N>A | p.Ala300Glu | p.A300E | Q8NG06 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DD-AADN-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRIM58 | SNV | Missense_Mutation | rs749287255 | c.280N>T | p.Arg94Trp | p.R94W | Q8NG06 | protein_coding | deleterious(0.02) | benign(0.031) | TCGA-O8-A75V-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM58 | SNV | Missense_Mutation | rs868777584 | c.85N>A | p.Val29Met | p.V29M | Q8NG06 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-44-2655-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TRIM58 | SNV | Missense_Mutation | c.668T>C | p.Val223Ala | p.V223A | Q8NG06 | protein_coding | tolerated(1) | benign(0) | TCGA-44-3917-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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