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Gene: TRIM38 |
Gene summary for TRIM38 |
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Gene information | Species | Human | Gene symbol | TRIM38 | Gene ID | 10475 |
Gene name | tripartite motif containing 38 | |
Gene Alias | RNF15 | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | A0A024QZY4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10475 | TRIM38 | LZE4T | Human | Esophagus | ESCC | 2.08e-03 | 1.06e-01 | 0.0811 |
10475 | TRIM38 | LZE5T | Human | Esophagus | ESCC | 5.11e-05 | 2.11e-01 | 0.0514 |
10475 | TRIM38 | LZE7T | Human | Esophagus | ESCC | 8.58e-05 | 2.54e-01 | 0.0667 |
10475 | TRIM38 | LZE8T | Human | Esophagus | ESCC | 5.86e-08 | 1.68e-01 | 0.067 |
10475 | TRIM38 | LZE20T | Human | Esophagus | ESCC | 3.00e-02 | 1.54e-01 | 0.0662 |
10475 | TRIM38 | LZE21D1 | Human | Esophagus | HGIN | 3.66e-03 | 3.59e-01 | 0.0632 |
10475 | TRIM38 | LZE24T | Human | Esophagus | ESCC | 7.86e-10 | 4.32e-01 | 0.0596 |
10475 | TRIM38 | LZE21T | Human | Esophagus | ESCC | 4.44e-05 | 3.93e-01 | 0.0655 |
10475 | TRIM38 | LZE6T | Human | Esophagus | ESCC | 1.20e-03 | 1.23e-01 | 0.0845 |
10475 | TRIM38 | P1T-E | Human | Esophagus | ESCC | 1.06e-10 | 4.88e-01 | 0.0875 |
10475 | TRIM38 | P2T-E | Human | Esophagus | ESCC | 1.64e-42 | 7.30e-01 | 0.1177 |
10475 | TRIM38 | P4T-E | Human | Esophagus | ESCC | 1.45e-11 | 3.57e-01 | 0.1323 |
10475 | TRIM38 | P5T-E | Human | Esophagus | ESCC | 8.06e-03 | 5.60e-02 | 0.1327 |
10475 | TRIM38 | P8T-E | Human | Esophagus | ESCC | 6.55e-17 | 3.35e-01 | 0.0889 |
10475 | TRIM38 | P9T-E | Human | Esophagus | ESCC | 1.43e-20 | 4.66e-01 | 0.1131 |
10475 | TRIM38 | P10T-E | Human | Esophagus | ESCC | 6.17e-08 | 1.04e-01 | 0.116 |
10475 | TRIM38 | P11T-E | Human | Esophagus | ESCC | 9.08e-09 | 3.81e-01 | 0.1426 |
10475 | TRIM38 | P12T-E | Human | Esophagus | ESCC | 9.77e-12 | 2.23e-01 | 0.1122 |
10475 | TRIM38 | P15T-E | Human | Esophagus | ESCC | 2.46e-09 | 2.14e-01 | 0.1149 |
10475 | TRIM38 | P16T-E | Human | Esophagus | ESCC | 1.73e-07 | 8.98e-02 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603227 | Esophagus | HGIN | viral process | 118/2587 | 415/18723 | 3.01e-15 | 6.22e-13 | 118 |
GO:001905827 | Esophagus | HGIN | viral life cycle | 93/2587 | 317/18723 | 3.66e-13 | 5.63e-11 | 93 |
GO:000989626 | Esophagus | HGIN | positive regulation of catabolic process | 126/2587 | 492/18723 | 1.46e-12 | 2.09e-10 | 126 |
GO:003133126 | Esophagus | HGIN | positive regulation of cellular catabolic process | 112/2587 | 427/18723 | 5.15e-12 | 6.72e-10 | 112 |
GO:001050616 | Esophagus | HGIN | regulation of autophagy | 84/2587 | 317/18723 | 1.39e-09 | 1.08e-07 | 84 |
GO:005079225 | Esophagus | HGIN | regulation of viral process | 50/2587 | 164/18723 | 2.53e-08 | 1.49e-06 | 50 |
GO:190390025 | Esophagus | HGIN | regulation of viral life cycle | 45/2587 | 148/18723 | 1.36e-07 | 6.78e-06 | 45 |
GO:004852419 | Esophagus | HGIN | positive regulation of viral process | 25/2587 | 65/18723 | 6.88e-07 | 2.95e-05 | 25 |
GO:004440326 | Esophagus | HGIN | biological process involved in symbiotic interaction | 71/2587 | 290/18723 | 7.09e-07 | 3.00e-05 | 71 |
GO:004312220 | Esophagus | HGIN | regulation of I-kappaB kinase/NF-kappaB signaling | 63/2587 | 249/18723 | 8.91e-07 | 3.61e-05 | 63 |
GO:000724918 | Esophagus | HGIN | I-kappaB kinase/NF-kappaB signaling | 67/2587 | 281/18723 | 3.84e-06 | 1.29e-04 | 67 |
GO:004312317 | Esophagus | HGIN | positive regulation of I-kappaB kinase/NF-kappaB signaling | 49/2587 | 186/18723 | 4.22e-06 | 1.40e-04 | 49 |
GO:000020916 | Esophagus | HGIN | protein polyubiquitination | 58/2587 | 236/18723 | 6.29e-06 | 1.97e-04 | 58 |
GO:005170127 | Esophagus | HGIN | biological process involved in interaction with host | 51/2587 | 203/18723 | 1.16e-05 | 3.29e-04 | 51 |
GO:005212627 | Esophagus | HGIN | movement in host environment | 43/2587 | 175/18723 | 9.45e-05 | 2.03e-03 | 43 |
GO:190390210 | Esophagus | HGIN | positive regulation of viral life cycle | 12/2587 | 29/18723 | 2.48e-04 | 4.38e-03 | 12 |
GO:004390320 | Esophagus | HGIN | regulation of biological process involved in symbiotic interaction | 20/2587 | 72/18723 | 1.39e-03 | 1.63e-02 | 20 |
GO:004659815 | Esophagus | HGIN | positive regulation of viral entry into host cell | 6/2587 | 11/18723 | 1.71e-03 | 1.86e-02 | 6 |
GO:007529415 | Esophagus | HGIN | positive regulation by symbiont of entry into host | 6/2587 | 11/18723 | 1.71e-03 | 1.86e-02 | 6 |
GO:004440927 | Esophagus | HGIN | entry into host | 34/2587 | 151/18723 | 2.43e-03 | 2.43e-02 | 34 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM38 | SNV | Missense_Mutation | novel | c.625C>A | p.Leu209Met | p.L209M | O00635 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-62-A472-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TRIM38 | SNV | Missense_Mutation | novel | c.561N>C | p.Gln187His | p.Q187H | O00635 | protein_coding | tolerated(1) | benign(0.003) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
TRIM38 | SNV | Missense_Mutation | c.928N>A | p.Asp310Asn | p.D310N | O00635 | protein_coding | tolerated(0.25) | possibly_damaging(0.732) | TCGA-91-A4BC-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRIM38 | SNV | Missense_Mutation | novel | c.1387N>T | p.Pro463Ser | p.P463S | O00635 | protein_coding | tolerated(0.06) | benign(0.009) | TCGA-21-1079-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TRIM38 | SNV | Missense_Mutation | novel | c.560N>G | p.Gln187Arg | p.Q187R | O00635 | protein_coding | tolerated(0.27) | benign(0.015) | TCGA-22-4594-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TRIM38 | SNV | Missense_Mutation | c.1328C>G | p.Ser443Cys | p.S443C | O00635 | protein_coding | deleterious(0.04) | benign(0.123) | TCGA-33-4586-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
TRIM38 | SNV | Missense_Mutation | rs758632326 | c.821N>A | p.Cys274Tyr | p.C274Y | O00635 | protein_coding | tolerated(0.11) | benign(0.029) | TCGA-56-8504-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRIM38 | SNV | Missense_Mutation | novel | c.596N>T | p.Trp199Leu | p.W199L | O00635 | protein_coding | deleterious(0.01) | possibly_damaging(0.728) | TCGA-58-A46M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM38 | SNV | Missense_Mutation | novel | c.597N>T | p.Trp199Cys | p.W199C | O00635 | protein_coding | tolerated(0.06) | probably_damaging(0.972) | TCGA-58-A46M-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRIM38 | SNV | Missense_Mutation | c.359N>T | p.Gln120Leu | p.Q120L | O00635 | protein_coding | deleterious(0.03) | possibly_damaging(0.657) | TCGA-66-2734-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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