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Gene: TNNT3 |
Gene summary for TNNT3 |
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Gene information | Species | Human | Gene symbol | TNNT3 | Gene ID | 7140 |
Gene name | troponin T3, fast skeletal type | |
Gene Alias | DA2B2 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P45378 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7140 | TNNT3 | LZE8T | Human | Esophagus | ESCC | 3.19e-08 | 4.89e-01 | 0.067 |
7140 | TNNT3 | P8T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.67e-01 | 0.0889 |
7140 | TNNT3 | P10T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.37e-01 | 0.116 |
7140 | TNNT3 | P20T-E | Human | Esophagus | ESCC | 1.51e-02 | 9.49e-02 | 0.1124 |
7140 | TNNT3 | P54T-E | Human | Esophagus | ESCC | 9.92e-04 | 1.91e-01 | 0.0975 |
7140 | TNNT3 | P62T-E | Human | Esophagus | ESCC | 8.76e-11 | 3.82e-01 | 0.1302 |
7140 | TNNT3 | P79T-E | Human | Esophagus | ESCC | 2.39e-24 | 9.22e-01 | 0.1154 |
7140 | TNNT3 | P80T-E | Human | Esophagus | ESCC | 3.35e-21 | 7.79e-01 | 0.155 |
7140 | TNNT3 | P89T-E | Human | Esophagus | ESCC | 4.36e-04 | 5.44e-01 | 0.1752 |
7140 | TNNT3 | P128T-E | Human | Esophagus | ESCC | 1.91e-31 | 1.18e+00 | 0.1241 |
7140 | TNNT3 | P130T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.71e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003103219 | Esophagus | ESCC | actomyosin structure organization | 108/8552 | 196/18723 | 4.86e-03 | 1.88e-02 | 108 |
GO:00434627 | Esophagus | ESCC | regulation of ATPase activity | 30/8552 | 46/18723 | 5.91e-03 | 2.18e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNNT3 | SNV | Missense_Mutation | novel | c.401N>T | p.Lys134Met | p.K134M | P45378 | protein_coding | deleterious(0.04) | benign(0.187) | TCGA-56-A4ZK-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNNT3 | SNV | Missense_Mutation | c.86N>A | p.Thr29Asn | p.T29N | P45378 | protein_coding | tolerated(0.46) | benign(0) | TCGA-70-6722-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
TNNT3 | SNV | Missense_Mutation | c.645C>G | p.Phe215Leu | p.F215L | P45378 | protein_coding | tolerated(0.05) | possibly_damaging(0.702) | TCGA-CR-6484-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
TNNT3 | SNV | Missense_Mutation | rs377446757 | c.302C>A | p.Ala101Glu | p.A101E | P45378 | protein_coding | tolerated(0.08) | probably_damaging(0.948) | TCGA-YL-A9WI-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
TNNT3 | SNV | Missense_Mutation | rs867571200 | c.253G>A | p.Glu85Lys | p.E85K | P45378 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNNT3 | SNV | Missense_Mutation | rs121434638 | c.188N>A | p.Arg63His | p.R63H | P45378 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IN-AB1X-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | leucovorin | SD |
TNNT3 | SNV | Missense_Mutation | rs750218802 | c.547N>T | p.Arg183Cys | p.R183C | P45378 | protein_coding | deleterious(0.04) | benign(0.139) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TNNT3 | SNV | Missense_Mutation | rs766438980 | c.766N>T | p.Arg256Cys | p.R256C | P45378 | protein_coding | deleterious(0) | benign(0.073) | TCGA-VQ-A8DV-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TNNT3 | SNV | Missense_Mutation | rs768888979 | c.40G>A | p.Glu14Lys | p.E14K | P45378 | protein_coding | tolerated_low_confidence(0.11) | probably_damaging(0.956) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
TNNT3 | SNV | Missense_Mutation | c.660N>C | p.Lys220Asn | p.K220N | P45378 | protein_coding | deleterious(0.03) | possibly_damaging(0.804) | TCGA-EL-A4JX-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7140 | TNNT3 | NA | activator | CHEMBL3039529 | TIRASEMTIV |
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