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Gene: TNIK |
Gene summary for TNIK |
Gene summary. |
Gene information | Species | Human | Gene symbol | TNIK | Gene ID | 23043 |
Gene name | TRAF2 and NCK interacting kinase | |
Gene Alias | MRT54 | |
Cytomap | 3q26.2-q26.31 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9UKE5 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23043 | TNIK | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.71e-10 | -4.18e-01 | 0.0155 |
23043 | TNIK | HTA11_347_2000001011 | Human | Colorectum | AD | 5.54e-06 | 5.49e-01 | -0.1954 |
23043 | TNIK | HTA11_866_3004761011 | Human | Colorectum | AD | 4.30e-07 | -5.18e-01 | 0.096 |
23043 | TNIK | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.89e-02 | -5.16e-01 | 0.0446 |
23043 | TNIK | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.40e-05 | -5.25e-01 | 0.0338 |
23043 | TNIK | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.03e-08 | -7.20e-01 | 0.2585 |
23043 | TNIK | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.94e-18 | -6.80e-01 | 0.3005 |
23043 | TNIK | A015-C-203 | Human | Colorectum | FAP | 8.21e-28 | -5.74e-01 | -0.1294 |
23043 | TNIK | A015-C-204 | Human | Colorectum | FAP | 1.15e-05 | -3.16e-01 | -0.0228 |
23043 | TNIK | A014-C-040 | Human | Colorectum | FAP | 8.87e-11 | -8.53e-01 | -0.1184 |
23043 | TNIK | A002-C-201 | Human | Colorectum | FAP | 1.01e-14 | -4.99e-01 | 0.0324 |
23043 | TNIK | A001-C-119 | Human | Colorectum | FAP | 8.54e-15 | -7.73e-01 | -0.1557 |
23043 | TNIK | A001-C-108 | Human | Colorectum | FAP | 1.42e-13 | -3.74e-01 | -0.0272 |
23043 | TNIK | A002-C-021 | Human | Colorectum | FAP | 2.75e-02 | -2.41e-01 | 0.1171 |
23043 | TNIK | A002-C-205 | Human | Colorectum | FAP | 2.55e-28 | -6.85e-01 | -0.1236 |
23043 | TNIK | A001-C-104 | Human | Colorectum | FAP | 4.56e-02 | -2.62e-01 | 0.0184 |
23043 | TNIK | A015-C-005 | Human | Colorectum | FAP | 5.16e-05 | -4.31e-01 | -0.0336 |
23043 | TNIK | A015-C-006 | Human | Colorectum | FAP | 1.06e-28 | -9.00e-01 | -0.0994 |
23043 | TNIK | A015-C-106 | Human | Colorectum | FAP | 2.71e-16 | -4.28e-01 | -0.0511 |
23043 | TNIK | A002-C-114 | Human | Colorectum | FAP | 5.31e-23 | -6.45e-01 | -0.1561 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0016055 | Colorectum | AD | Wnt signaling pathway | 130/3918 | 444/18723 | 1.60e-05 | 3.37e-04 | 130 |
GO:0198738 | Colorectum | AD | cell-cell signaling by wnt | 130/3918 | 446/18723 | 2.02e-05 | 4.10e-04 | 130 |
GO:0046777 | Colorectum | AD | protein autophosphorylation | 74/3918 | 227/18723 | 2.48e-05 | 4.76e-04 | 74 |
GO:0031532 | Colorectum | AD | actin cytoskeleton reorganization | 41/3918 | 107/18723 | 2.81e-05 | 5.28e-04 | 41 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0032528 | Colorectum | AD | microvillus organization | 14/3918 | 24/18723 | 6.90e-05 | 1.11e-03 | 14 |
GO:0051403 | Colorectum | AD | stress-activated MAPK cascade | 72/3918 | 239/18723 | 4.77e-04 | 5.25e-03 | 72 |
GO:0031098 | Colorectum | AD | stress-activated protein kinase signaling cascade | 74/3918 | 247/18723 | 4.80e-04 | 5.27e-03 | 74 |
GO:0030033 | Colorectum | AD | microvillus assembly | 9/3918 | 16/18723 | 2.06e-03 | 1.64e-02 | 9 |
GO:0070302 | Colorectum | AD | regulation of stress-activated protein kinase signaling cascade | 58/3918 | 195/18723 | 2.21e-03 | 1.74e-02 | 58 |
GO:0032872 | Colorectum | AD | regulation of stress-activated MAPK cascade | 57/3918 | 192/18723 | 2.51e-03 | 1.92e-02 | 57 |
GO:0016358 | Colorectum | AD | dendrite development | 69/3918 | 243/18723 | 3.32e-03 | 2.42e-02 | 69 |
GO:00726591 | Colorectum | SER | protein localization to plasma membrane | 92/2897 | 284/18723 | 6.36e-13 | 1.86e-10 | 92 |
GO:19907781 | Colorectum | SER | protein localization to cell periphery | 98/2897 | 333/18723 | 6.09e-11 | 9.57e-09 | 98 |
GO:00325281 | Colorectum | SER | microvillus organization | 14/2897 | 24/18723 | 1.83e-06 | 7.80e-05 | 14 |
GO:00467771 | Colorectum | SER | protein autophosphorylation | 60/2897 | 227/18723 | 1.36e-05 | 4.25e-04 | 60 |
GO:00160551 | Colorectum | SER | Wnt signaling pathway | 97/2897 | 444/18723 | 2.02e-04 | 3.68e-03 | 97 |
GO:00300331 | Colorectum | SER | microvillus assembly | 9/2897 | 16/18723 | 2.03e-04 | 3.68e-03 | 9 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNIK | SNV | Missense_Mutation | c.371C>A | p.Thr124Lys | p.T124K | Q9UKE5 | protein_coding | deleterious(0.02) | benign(0.191) | TCGA-AA-3973-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | SD | |
TNIK | SNV | Missense_Mutation | novel | c.467N>A | p.Gly156Glu | p.G156E | Q9UKE5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A004-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TNIK | SNV | Missense_Mutation | c.3057G>T | p.Lys1019Asn | p.K1019N | Q9UKE5 | protein_coding | deleterious(0.01) | possibly_damaging(0.636) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TNIK | SNV | Missense_Mutation | novel | c.3756N>C | p.Met1252Ile | p.M1252I | Q9UKE5 | protein_coding | tolerated(0.32) | benign(0.349) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TNIK | SNV | Missense_Mutation | c.1649N>T | p.Ala550Val | p.A550V | Q9UKE5 | protein_coding | tolerated(0.3) | benign(0.074) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TNIK | SNV | Missense_Mutation | c.424N>G | p.Ser142Gly | p.S142G | Q9UKE5 | protein_coding | deleterious(0) | benign(0.211) | TCGA-AZ-6599-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TNIK | SNV | Missense_Mutation | novel | c.3017N>C | p.Leu1006Pro | p.L1006P | Q9UKE5 | protein_coding | tolerated(0.32) | benign(0.067) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TNIK | SNV | Missense_Mutation | c.2318N>T | p.Pro773Leu | p.P773L | Q9UKE5 | protein_coding | tolerated(0.31) | benign(0.015) | TCGA-D5-5538-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | calcium | PD | |
TNIK | SNV | Missense_Mutation | c.2105N>C | p.Gln702Pro | p.Q702P | Q9UKE5 | protein_coding | tolerated(0.06) | benign(0.042) | TCGA-D5-6924-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TNIK | SNV | Missense_Mutation | c.466G>T | p.Gly156Trp | p.G156W | Q9UKE5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23043 | TNIK | ENZYME, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE | SB-202190 | SB-202190 | 22951114 | |
23043 | TNIK | ENZYME, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
23043 | TNIK | ENZYME, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE | inhibitor | 135652717 | STAUROSPORINE | |
23043 | TNIK | ENZYME, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE | inhibitor | 249565872 | ||
23043 | TNIK | ENZYME, DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE | CEP-1347 | CEP-1347 | 24044867 |
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