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Gene: TNFAIP6 |
Gene summary for TNFAIP6 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TNFAIP6 | Gene ID | 7130 |
Gene name | TNF alpha induced protein 6 | |
Gene Alias | TSG-6 | |
Cytomap | 2q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P98066 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7130 | TNFAIP6 | GSM4909281 | Human | Breast | IDC | 1.39e-03 | -2.76e-01 | 0.21 |
7130 | TNFAIP6 | GSM4909282 | Human | Breast | IDC | 6.80e-14 | 4.73e-01 | -0.0288 |
7130 | TNFAIP6 | GSM4909285 | Human | Breast | IDC | 2.88e-05 | -2.87e-01 | 0.21 |
7130 | TNFAIP6 | GSM4909286 | Human | Breast | IDC | 3.69e-10 | -3.26e-01 | 0.1081 |
7130 | TNFAIP6 | GSM4909287 | Human | Breast | IDC | 1.48e-07 | -3.04e-01 | 0.2057 |
7130 | TNFAIP6 | GSM4909290 | Human | Breast | IDC | 1.11e-08 | -3.26e-01 | 0.2096 |
7130 | TNFAIP6 | GSM4909291 | Human | Breast | IDC | 1.07e-03 | -3.06e-01 | 0.1753 |
7130 | TNFAIP6 | GSM4909293 | Human | Breast | IDC | 1.75e-09 | -3.24e-01 | 0.1581 |
7130 | TNFAIP6 | GSM4909294 | Human | Breast | IDC | 7.71e-11 | -3.26e-01 | 0.2022 |
7130 | TNFAIP6 | GSM4909295 | Human | Breast | IDC | 4.83e-05 | -3.26e-01 | 0.0898 |
7130 | TNFAIP6 | GSM4909296 | Human | Breast | IDC | 8.04e-10 | -3.15e-01 | 0.1524 |
7130 | TNFAIP6 | GSM4909297 | Human | Breast | IDC | 7.71e-11 | -3.20e-01 | 0.1517 |
7130 | TNFAIP6 | GSM4909298 | Human | Breast | IDC | 7.71e-11 | -3.26e-01 | 0.1551 |
7130 | TNFAIP6 | GSM4909299 | Human | Breast | IDC | 3.74e-05 | -3.12e-01 | 0.035 |
7130 | TNFAIP6 | GSM4909300 | Human | Breast | IDC | 2.71e-04 | -3.26e-01 | 0.0334 |
7130 | TNFAIP6 | GSM4909301 | Human | Breast | IDC | 1.69e-10 | -3.26e-01 | 0.1577 |
7130 | TNFAIP6 | GSM4909302 | Human | Breast | IDC | 3.88e-07 | -3.01e-01 | 0.1545 |
7130 | TNFAIP6 | GSM4909303 | Human | Breast | IDC | 2.16e-02 | -3.26e-01 | 0.0438 |
7130 | TNFAIP6 | GSM4909304 | Human | Breast | IDC | 1.69e-10 | -3.26e-01 | 0.1636 |
7130 | TNFAIP6 | GSM4909305 | Human | Breast | IDC | 2.42e-08 | -3.26e-01 | 0.0436 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0050727 | Breast | Precancer | regulation of inflammatory response | 44/1080 | 386/18723 | 1.26e-05 | 3.22e-04 | 44 |
GO:00507271 | Breast | IDC | regulation of inflammatory response | 48/1434 | 386/18723 | 5.99e-04 | 7.54e-03 | 48 |
GO:00507272 | Breast | DCIS | regulation of inflammatory response | 46/1390 | 386/18723 | 9.91e-04 | 1.10e-02 | 46 |
GO:00321021 | Breast | DCIS | negative regulation of response to external stimulus | 46/1390 | 420/18723 | 5.19e-03 | 3.81e-02 | 46 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNFAIP6 | SNV | Missense_Mutation | rs373227124 | c.346N>T | p.Arg116Cys | p.R116C | P98066 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-KK-A7B1-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
TNFAIP6 | SNV | Missense_Mutation | c.167N>T | p.Ala56Val | p.A56V | P98066 | protein_coding | tolerated(0.14) | benign(0.295) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
TNFAIP6 | SNV | Missense_Mutation | novel | c.455N>A | p.Pro152Gln | p.P152Q | P98066 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-E8-A2EA-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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