![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMEM94 |
Gene summary for TMEM94 |
![]() |
Gene information | Species | Human | Gene symbol | TMEM94 | Gene ID | 9772 |
Gene name | transmembrane protein 94 | |
Gene Alias | IDDCDF | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B7Z9U5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9772 | TMEM94 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.95e-04 | 2.56e-01 | -0.1808 |
9772 | TMEM94 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.26e-06 | 3.41e-01 | -0.1954 |
9772 | TMEM94 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.79e-04 | 8.13e-01 | -0.2602 |
9772 | TMEM94 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.74e-03 | 3.38e-01 | -0.1526 |
9772 | TMEM94 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.01e-02 | 2.52e-01 | -0.1464 |
9772 | TMEM94 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.22e-03 | 2.50e-01 | -0.059 |
9772 | TMEM94 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.33e-04 | 2.64e-01 | 0.0674 |
9772 | TMEM94 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.81e-03 | 3.61e-01 | 0.3859 |
9772 | TMEM94 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.69e-02 | 2.77e-01 | 0.3005 |
9772 | TMEM94 | LZE4T | Human | Esophagus | ESCC | 9.16e-04 | 9.11e-02 | 0.0811 |
9772 | TMEM94 | LZE7T | Human | Esophagus | ESCC | 3.18e-04 | 2.61e-01 | 0.0667 |
9772 | TMEM94 | LZE24T | Human | Esophagus | ESCC | 1.03e-08 | 3.63e-01 | 0.0596 |
9772 | TMEM94 | P1T-E | Human | Esophagus | ESCC | 6.43e-03 | 3.42e-01 | 0.0875 |
9772 | TMEM94 | P2T-E | Human | Esophagus | ESCC | 2.36e-14 | 1.97e-01 | 0.1177 |
9772 | TMEM94 | P4T-E | Human | Esophagus | ESCC | 3.86e-06 | 7.53e-02 | 0.1323 |
9772 | TMEM94 | P8T-E | Human | Esophagus | ESCC | 1.52e-12 | 2.47e-01 | 0.0889 |
9772 | TMEM94 | P10T-E | Human | Esophagus | ESCC | 5.55e-57 | 1.04e+00 | 0.116 |
9772 | TMEM94 | P11T-E | Human | Esophagus | ESCC | 2.83e-04 | 2.54e-01 | 0.1426 |
9772 | TMEM94 | P12T-E | Human | Esophagus | ESCC | 1.03e-17 | 2.84e-01 | 0.1122 |
9772 | TMEM94 | P15T-E | Human | Esophagus | ESCC | 5.91e-15 | 2.44e-01 | 0.1149 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM94 | deletion | Frame_Shift_Del | rs753764149 | c.681delN | p.Phe230SerfsTer31 | p.F230Sfs*31 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
TMEM94 | deletion | Frame_Shift_Del | rs768883920 | c.2706delN | p.Ser905ProfsTer13 | p.S905Pfs*13 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
TMEM94 | deletion | Frame_Shift_Del | rs753764149 | c.681delN | p.Phe230SerfsTer31 | p.F230Sfs*31 | protein_coding | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
TMEM94 | deletion | Frame_Shift_Del | rs768883920 | c.2706delN | p.Ser905ProfsTer13 | p.S905Pfs*13 | protein_coding | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TMEM94 | deletion | Frame_Shift_Del | rs768883920 | c.2706delN | p.Ser905ProfsTer13 | p.S905Pfs*13 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
TMEM94 | deletion | Frame_Shift_Del | c.3457delN | p.His1155IlefsTer95 | p.H1155Ifs*95 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||||
TMEM94 | SNV | Missense_Mutation | rs760789874 | c.1139N>T | p.Thr380Met | p.T380M | protein_coding | deleterious(0.03) | probably_damaging(0.993) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM94 | SNV | Missense_Mutation | rs753606974 | c.1492N>A | p.Asp498Asn | p.D498N | protein_coding | tolerated(0.29) | benign(0) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM94 | SNV | Missense_Mutation | novel | c.339N>A | p.Phe113Leu | p.F113L | protein_coding | tolerated(1) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMEM94 | SNV | Missense_Mutation | novel | c.1937N>C | p.Leu646Pro | p.L646P | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |