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Gene: TMEM184A |
Gene summary for TMEM184A |
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Gene information | Species | Human | Gene symbol | TMEM184A | Gene ID | 202915 |
Gene name | transmembrane protein 184A | |
Gene Alias | SDMG1 | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q6ZMB5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
202915 | TMEM184A | LZE20T | Human | Esophagus | ESCC | 1.59e-12 | 3.64e-01 | 0.0662 |
202915 | TMEM184A | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 3.28e-01 | 0.068 |
202915 | TMEM184A | LZE24T | Human | Esophagus | ESCC | 4.15e-02 | 9.91e-02 | 0.0596 |
202915 | TMEM184A | P1T-E | Human | Esophagus | ESCC | 3.58e-07 | 3.41e-01 | 0.0875 |
202915 | TMEM184A | P2T-E | Human | Esophagus | ESCC | 1.78e-03 | 8.78e-02 | 0.1177 |
202915 | TMEM184A | P5T-E | Human | Esophagus | ESCC | 8.84e-05 | 9.96e-02 | 0.1327 |
202915 | TMEM184A | P8T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.90e-01 | 0.0889 |
202915 | TMEM184A | P11T-E | Human | Esophagus | ESCC | 1.20e-09 | 3.15e-01 | 0.1426 |
202915 | TMEM184A | P15T-E | Human | Esophagus | ESCC | 3.12e-08 | 2.34e-01 | 0.1149 |
202915 | TMEM184A | P17T-E | Human | Esophagus | ESCC | 8.50e-05 | 2.15e-01 | 0.1278 |
202915 | TMEM184A | P20T-E | Human | Esophagus | ESCC | 3.97e-02 | 8.10e-02 | 0.1124 |
202915 | TMEM184A | P22T-E | Human | Esophagus | ESCC | 2.61e-16 | 1.12e-01 | 0.1236 |
202915 | TMEM184A | P23T-E | Human | Esophagus | ESCC | 2.37e-12 | 3.49e-01 | 0.108 |
202915 | TMEM184A | P26T-E | Human | Esophagus | ESCC | 7.98e-13 | 2.14e-01 | 0.1276 |
202915 | TMEM184A | P27T-E | Human | Esophagus | ESCC | 4.17e-05 | 9.30e-02 | 0.1055 |
202915 | TMEM184A | P28T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.75e-01 | 0.1149 |
202915 | TMEM184A | P31T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.64e-01 | 0.1251 |
202915 | TMEM184A | P37T-E | Human | Esophagus | ESCC | 1.53e-03 | 1.01e-01 | 0.1371 |
202915 | TMEM184A | P38T-E | Human | Esophagus | ESCC | 5.18e-03 | 1.83e-01 | 0.127 |
202915 | TMEM184A | P39T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.38e-01 | 0.0894 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM184A | deletion | Frame_Shift_Del | c.133delG | p.Ala45ProfsTer92 | p.A45Pfs*92 | Q6ZMB5 | protein_coding | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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