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Gene: TFPI2 |
Gene summary for TFPI2 |
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Gene information | Species | Human | Gene symbol | TFPI2 | Gene ID | 7980 |
Gene name | tissue factor pathway inhibitor 2 | |
Gene Alias | PP5 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P48307 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7980 | TFPI2 | AEH-subject1 | Human | Endometrium | AEH | 3.42e-03 | 3.32e-01 | -0.3059 |
7980 | TFPI2 | AEH-subject5 | Human | Endometrium | AEH | 5.65e-06 | 4.83e-01 | -0.2953 |
7980 | TFPI2 | EEC-subject2 | Human | Endometrium | EEC | 4.43e-06 | -1.59e-01 | -0.2607 |
7980 | TFPI2 | EEC-subject3 | Human | Endometrium | EEC | 3.57e-08 | -1.65e-01 | -0.2525 |
7980 | TFPI2 | GSM5276934 | Human | Endometrium | EEC | 8.04e-09 | 4.99e-01 | -0.0913 |
7980 | TFPI2 | GSM5276935 | Human | Endometrium | EEC | 2.96e-18 | 6.29e-01 | -0.123 |
7980 | TFPI2 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.12e-04 | -2.20e-01 | -0.1869 |
7980 | TFPI2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.61e-04 | -1.67e-01 | -0.1875 |
7980 | TFPI2 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.16e-08 | -2.36e-01 | -0.1883 |
7980 | TFPI2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.00e-05 | 2.19e-01 | -0.1934 |
7980 | TFPI2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.09e-14 | -1.36e-01 | -0.1917 |
7980 | TFPI2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.54e-08 | -1.44e-01 | -0.1916 |
7980 | TFPI2 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 2.32e-06 | -1.59e-01 | -0.1269 |
7980 | TFPI2 | LZE6T | Human | Esophagus | ESCC | 3.38e-04 | 1.08e+00 | 0.0845 |
7980 | TFPI2 | P11T-E | Human | Esophagus | ESCC | 4.67e-13 | 2.32e+00 | 0.1426 |
7980 | TFPI2 | P24T-E | Human | Esophagus | ESCC | 5.30e-08 | 3.80e-01 | 0.1287 |
7980 | TFPI2 | P32T-E | Human | Esophagus | ESCC | 3.56e-13 | 7.58e-01 | 0.1666 |
7980 | TFPI2 | P37T-E | Human | Esophagus | ESCC | 2.58e-25 | 1.33e+00 | 0.1371 |
7980 | TFPI2 | P52T-E | Human | Esophagus | ESCC | 1.63e-09 | 5.55e-01 | 0.1555 |
7980 | TFPI2 | P75T-E | Human | Esophagus | ESCC | 3.60e-10 | 7.34e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004206016 | Endometrium | AEH | wound healing | 91/2100 | 422/18723 | 4.85e-10 | 4.61e-08 | 91 |
GO:005254716 | Endometrium | AEH | regulation of peptidase activity | 85/2100 | 461/18723 | 2.47e-06 | 7.11e-05 | 85 |
GO:005254816 | Endometrium | AEH | regulation of endopeptidase activity | 76/2100 | 432/18723 | 4.42e-05 | 7.43e-04 | 76 |
GO:004586116 | Endometrium | AEH | negative regulation of proteolysis | 63/2100 | 351/18723 | 1.07e-04 | 1.53e-03 | 63 |
GO:00075967 | Endometrium | AEH | blood coagulation | 43/2100 | 217/18723 | 1.42e-04 | 1.89e-03 | 43 |
GO:00075997 | Endometrium | AEH | hemostasis | 43/2100 | 222/18723 | 2.39e-04 | 2.86e-03 | 43 |
GO:00508177 | Endometrium | AEH | coagulation | 43/2100 | 222/18723 | 2.39e-04 | 2.86e-03 | 43 |
GO:005134610 | Endometrium | AEH | negative regulation of hydrolase activity | 65/2100 | 379/18723 | 3.18e-04 | 3.57e-03 | 65 |
GO:005087815 | Endometrium | AEH | regulation of body fluid levels | 64/2100 | 379/18723 | 5.40e-04 | 5.44e-03 | 64 |
GO:001046610 | Endometrium | AEH | negative regulation of peptidase activity | 43/2100 | 262/18723 | 6.78e-03 | 3.95e-02 | 43 |
GO:004206017 | Endometrium | EEC | wound healing | 92/2168 | 422/18723 | 1.12e-09 | 9.58e-08 | 92 |
GO:005254717 | Endometrium | EEC | regulation of peptidase activity | 91/2168 | 461/18723 | 2.00e-07 | 8.93e-06 | 91 |
GO:004586117 | Endometrium | EEC | negative regulation of proteolysis | 72/2168 | 351/18723 | 8.46e-07 | 2.98e-05 | 72 |
GO:005254817 | Endometrium | EEC | regulation of endopeptidase activity | 82/2168 | 432/18723 | 3.96e-06 | 1.04e-04 | 82 |
GO:005134615 | Endometrium | EEC | negative regulation of hydrolase activity | 72/2168 | 379/18723 | 1.46e-05 | 2.87e-04 | 72 |
GO:000759613 | Endometrium | EEC | blood coagulation | 44/2168 | 217/18723 | 1.42e-04 | 1.84e-03 | 44 |
GO:000759913 | Endometrium | EEC | hemostasis | 44/2168 | 222/18723 | 2.43e-04 | 2.85e-03 | 44 |
GO:005081713 | Endometrium | EEC | coagulation | 44/2168 | 222/18723 | 2.43e-04 | 2.85e-03 | 44 |
GO:001046615 | Endometrium | EEC | negative regulation of peptidase activity | 49/2168 | 262/18723 | 4.64e-04 | 4.79e-03 | 49 |
GO:001095114 | Endometrium | EEC | negative regulation of endopeptidase activity | 47/2168 | 252/18723 | 6.37e-04 | 6.25e-03 | 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFPI2 | SNV | Missense_Mutation | novel | c.151N>T | p.Arg51Cys | p.R51C | P48307 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-H7-8501-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | CR |
TFPI2 | SNV | Missense_Mutation | c.98N>T | p.Ala33Val | p.A33V | P48307 | protein_coding | tolerated(0.11) | benign(0.162) | TCGA-BR-8297-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | SD | |
TFPI2 | SNV | Missense_Mutation | c.97G>A | p.Ala33Thr | p.A33T | P48307 | protein_coding | tolerated(0.4) | benign(0.022) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TFPI2 | SNV | Missense_Mutation | c.98C>T | p.Ala33Val | p.A33V | P48307 | protein_coding | tolerated(0.11) | benign(0.162) | TCGA-BR-A4J2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | CR | |
TFPI2 | SNV | Missense_Mutation | novel | c.338N>C | p.Tyr113Ser | p.Y113S | P48307 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D7-A747-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | epirubicinum | PD |
TFPI2 | deletion | Frame_Shift_Del | rs768025475 | c.203delN | p.Gly68AlafsTer22 | p.G68Afs*22 | P48307 | protein_coding | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7980 | TFPI2 | PROTEASE INHIBITOR, DRUGGABLE GENOME | HEPARIN | HEPARIN | 2416032 | |
7980 | TFPI2 | PROTEASE INHIBITOR, DRUGGABLE GENOME | PROTEASE INHIBITORS | 3276312 |
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