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Gene: TFAP2C |
Gene summary for TFAP2C |
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Gene information | Species | Human | Gene symbol | TFAP2C | Gene ID | 7022 |
Gene name | transcription factor AP-2 gamma | |
Gene Alias | AP2-GAMMA | |
Cytomap | 20q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q92754 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7022 | TFAP2C | LZE2T | Human | Esophagus | ESCC | 1.72e-02 | 2.70e-01 | 0.082 |
7022 | TFAP2C | LZE4T | Human | Esophagus | ESCC | 5.26e-05 | 1.16e-01 | 0.0811 |
7022 | TFAP2C | LZE20T | Human | Esophagus | ESCC | 5.18e-06 | 1.47e-01 | 0.0662 |
7022 | TFAP2C | LZE24T | Human | Esophagus | ESCC | 3.60e-12 | 2.94e-01 | 0.0596 |
7022 | TFAP2C | P1T-E | Human | Esophagus | ESCC | 4.10e-10 | 7.53e-01 | 0.0875 |
7022 | TFAP2C | P2T-E | Human | Esophagus | ESCC | 3.02e-45 | 9.79e-01 | 0.1177 |
7022 | TFAP2C | P4T-E | Human | Esophagus | ESCC | 1.61e-02 | 9.05e-02 | 0.1323 |
7022 | TFAP2C | P5T-E | Human | Esophagus | ESCC | 7.68e-13 | 1.61e-01 | 0.1327 |
7022 | TFAP2C | P8T-E | Human | Esophagus | ESCC | 1.66e-19 | 2.73e-01 | 0.0889 |
7022 | TFAP2C | P9T-E | Human | Esophagus | ESCC | 3.70e-05 | 1.99e-01 | 0.1131 |
7022 | TFAP2C | P10T-E | Human | Esophagus | ESCC | 2.43e-09 | 2.87e-01 | 0.116 |
7022 | TFAP2C | P11T-E | Human | Esophagus | ESCC | 4.66e-10 | 7.39e-01 | 0.1426 |
7022 | TFAP2C | P12T-E | Human | Esophagus | ESCC | 2.99e-34 | 8.58e-01 | 0.1122 |
7022 | TFAP2C | P15T-E | Human | Esophagus | ESCC | 7.71e-33 | 9.42e-01 | 0.1149 |
7022 | TFAP2C | P16T-E | Human | Esophagus | ESCC | 7.76e-69 | 1.66e+00 | 0.1153 |
7022 | TFAP2C | P20T-E | Human | Esophagus | ESCC | 8.23e-25 | 7.08e-01 | 0.1124 |
7022 | TFAP2C | P21T-E | Human | Esophagus | ESCC | 7.78e-22 | 3.52e-01 | 0.1617 |
7022 | TFAP2C | P22T-E | Human | Esophagus | ESCC | 2.77e-21 | 5.08e-01 | 0.1236 |
7022 | TFAP2C | P23T-E | Human | Esophagus | ESCC | 1.58e-18 | 5.38e-01 | 0.108 |
7022 | TFAP2C | P24T-E | Human | Esophagus | ESCC | 2.26e-11 | 2.53e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:00400295 | Esophagus | ESCC | regulation of gene expression, epigenetic | 74/8552 | 105/18723 | 2.24e-07 | 3.42e-06 | 74 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:006145825 | Skin | cSCC | reproductive system development | 149/4864 | 427/18723 | 2.30e-05 | 2.65e-04 | 149 |
GO:004860824 | Skin | cSCC | reproductive structure development | 148/4864 | 424/18723 | 2.40e-05 | 2.74e-04 | 148 |
GO:00085845 | Skin | cSCC | male gonad development | 51/4864 | 141/18723 | 4.70e-03 | 2.40e-02 | 51 |
GO:00465465 | Skin | cSCC | development of primary male sexual characteristics | 51/4864 | 142/18723 | 5.52e-03 | 2.73e-02 | 51 |
GO:004002912 | Skin | cSCC | regulation of gene expression, epigenetic | 39/4864 | 105/18723 | 7.56e-03 | 3.53e-02 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
TFAP2C | ICAF | Endometrium | EEC | USP53,SULT1C4,NT5E, etc. | 3.02e-01 | ![]() |
TFAP2C | CD8TRM | Skin | cSCC | LDLRAP1,KRT1,ZNF165, etc. | 1.64e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFAP2C | SNV | Missense_Mutation | c.541N>T | p.Asp181Tyr | p.D181Y | Q92754 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-44-7671-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
TFAP2C | SNV | Missense_Mutation | novel | c.1076G>T | p.Cys359Phe | p.C359F | Q92754 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-49-AAR4-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxol | PD |
TFAP2C | SNV | Missense_Mutation | novel | c.865N>A | p.Leu289Ile | p.L289I | Q92754 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TFAP2C | SNV | Missense_Mutation | c.44G>C | p.Cys15Ser | p.C15S | Q92754 | protein_coding | tolerated(0.4) | benign(0) | TCGA-80-5611-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD | |
TFAP2C | SNV | Missense_Mutation | novel | c.856N>C | p.Gly286Arg | p.G286R | Q92754 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-8358-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TFAP2C | SNV | Missense_Mutation | c.559N>A | p.Leu187Met | p.L187M | Q92754 | protein_coding | tolerated(0.34) | benign(0.02) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
TFAP2C | SNV | Missense_Mutation | c.803G>A | p.Arg268Lys | p.R268K | Q92754 | protein_coding | deleterious(0.01) | possibly_damaging(0.721) | TCGA-MP-A4T6-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TFAP2C | SNV | Missense_Mutation | rs748899621 | c.550N>T | p.His184Tyr | p.H184Y | Q92754 | protein_coding | tolerated(0.19) | benign(0.239) | TCGA-43-2581-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
TFAP2C | SNV | Missense_Mutation | novel | c.1220N>T | p.Ala407Val | p.A407V | Q92754 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
TFAP2C | SNV | Missense_Mutation | novel | c.544N>T | p.Asp182Tyr | p.D182Y | Q92754 | protein_coding | deleterious(0.01) | possibly_damaging(0.809) | TCGA-77-A5GH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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