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Gene: TECPR1 |
Gene summary for TECPR1 |
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Gene information | Species | Human | Gene symbol | TECPR1 | Gene ID | 25851 |
Gene name | tectonin beta-propeller repeat containing 1 | |
Gene Alias | TECPR1 | |
Cytomap | 7q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | Q7Z6L1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25851 | TECPR1 | LZE7T | Human | Esophagus | ESCC | 2.49e-03 | 1.31e-01 | 0.0667 |
25851 | TECPR1 | LZE24T | Human | Esophagus | ESCC | 7.68e-07 | 7.92e-02 | 0.0596 |
25851 | TECPR1 | P1T-E | Human | Esophagus | ESCC | 6.34e-04 | 2.68e-01 | 0.0875 |
25851 | TECPR1 | P2T-E | Human | Esophagus | ESCC | 3.61e-05 | 1.39e-01 | 0.1177 |
25851 | TECPR1 | P4T-E | Human | Esophagus | ESCC | 9.70e-05 | 5.32e-02 | 0.1323 |
25851 | TECPR1 | P5T-E | Human | Esophagus | ESCC | 4.17e-05 | 8.31e-02 | 0.1327 |
25851 | TECPR1 | P8T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.04e-01 | 0.0889 |
25851 | TECPR1 | P9T-E | Human | Esophagus | ESCC | 5.51e-03 | 3.86e-02 | 0.1131 |
25851 | TECPR1 | P10T-E | Human | Esophagus | ESCC | 4.31e-06 | 9.53e-02 | 0.116 |
25851 | TECPR1 | P11T-E | Human | Esophagus | ESCC | 3.21e-06 | 1.50e-01 | 0.1426 |
25851 | TECPR1 | P12T-E | Human | Esophagus | ESCC | 4.41e-07 | 1.16e-01 | 0.1122 |
25851 | TECPR1 | P15T-E | Human | Esophagus | ESCC | 7.46e-09 | 1.65e-01 | 0.1149 |
25851 | TECPR1 | P16T-E | Human | Esophagus | ESCC | 4.29e-24 | 4.28e-01 | 0.1153 |
25851 | TECPR1 | P17T-E | Human | Esophagus | ESCC | 2.77e-04 | 1.95e-01 | 0.1278 |
25851 | TECPR1 | P19T-E | Human | Esophagus | ESCC | 3.38e-03 | 2.55e-01 | 0.1662 |
25851 | TECPR1 | P20T-E | Human | Esophagus | ESCC | 1.34e-12 | 1.63e-01 | 0.1124 |
25851 | TECPR1 | P21T-E | Human | Esophagus | ESCC | 3.68e-05 | 1.12e-01 | 0.1617 |
25851 | TECPR1 | P22T-E | Human | Esophagus | ESCC | 4.99e-03 | 7.51e-02 | 0.1236 |
25851 | TECPR1 | P23T-E | Human | Esophagus | ESCC | 1.89e-06 | 1.22e-01 | 0.108 |
25851 | TECPR1 | P26T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.07e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:00973523 | Esophagus | ESCC | autophagosome maturation | 31/8552 | 40/18723 | 4.04e-05 | 3.26e-04 | 31 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
GO:003298411 | Liver | HCC | protein-containing complex disassembly | 138/7958 | 224/18723 | 5.59e-09 | 1.46e-07 | 138 |
GO:00973521 | Liver | HCC | autophagosome maturation | 30/7958 | 40/18723 | 3.04e-05 | 3.12e-04 | 30 |
GO:0022411113 | Thyroid | PTC | cellular component disassembly | 232/5968 | 443/18723 | 1.36e-19 | 1.75e-17 | 232 |
GO:0016236110 | Thyroid | PTC | macroautophagy | 167/5968 | 291/18723 | 1.51e-19 | 1.91e-17 | 167 |
GO:0032984110 | Thyroid | PTC | protein-containing complex disassembly | 114/5968 | 224/18723 | 2.26e-09 | 6.33e-08 | 114 |
GO:002241124 | Thyroid | ATC | cellular component disassembly | 248/6293 | 443/18723 | 1.34e-22 | 3.69e-20 | 248 |
GO:001623623 | Thyroid | ATC | macroautophagy | 169/6293 | 291/18723 | 6.56e-18 | 7.69e-16 | 169 |
GO:003298422 | Thyroid | ATC | protein-containing complex disassembly | 121/6293 | 224/18723 | 2.25e-10 | 6.59e-09 | 121 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa0513142 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
hsa0513152 | Liver | HCC | Shigellosis | 150/4020 | 247/8465 | 1.53e-05 | 1.04e-04 | 5.81e-05 | 150 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TECPR1 | SNV | Missense_Mutation | novel | c.3236N>A | p.Cys1079Tyr | p.C1079Y | Q7Z6L1 | protein_coding | tolerated(0.06) | benign(0.11) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
TECPR1 | SNV | Missense_Mutation | c.724N>T | p.Pro242Ser | p.P242S | Q7Z6L1 | protein_coding | deleterious(0.01) | possibly_damaging(0.543) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | |
TECPR1 | SNV | Missense_Mutation | novel | c.523N>C | p.Trp175Arg | p.W175R | Q7Z6L1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
TECPR1 | SNV | Missense_Mutation | rs774839041 | c.3122C>T | p.Ala1041Val | p.A1041V | Q7Z6L1 | protein_coding | tolerated(1) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TECPR1 | SNV | Missense_Mutation | rs777185277 | c.2386G>A | p.Gly796Ser | p.G796S | Q7Z6L1 | protein_coding | deleterious(0.03) | probably_damaging(0.984) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TECPR1 | SNV | Missense_Mutation | novel | c.743T>C | p.Ile248Thr | p.I248T | Q7Z6L1 | protein_coding | deleterious(0) | benign(0.193) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TECPR1 | SNV | Missense_Mutation | c.850N>A | p.Val284Met | p.V284M | Q7Z6L1 | protein_coding | deleterious(0.03) | possibly_damaging(0.458) | TCGA-BS-A0U8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
TECPR1 | SNV | Missense_Mutation | c.533T>C | p.Ile178Thr | p.I178T | Q7Z6L1 | protein_coding | deleterious(0) | benign(0.424) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TECPR1 | SNV | Missense_Mutation | rs767172301 | c.802N>T | p.Arg268Trp | p.R268W | Q7Z6L1 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-D1-A0ZS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TECPR1 | SNV | Missense_Mutation | rs375878463 | c.1918N>A | p.Asp640Asn | p.D640N | Q7Z6L1 | protein_coding | tolerated(0.19) | probably_damaging(0.913) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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