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Gene: TCFL5 |
Gene summary for TCFL5 |
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Gene information | Species | Human | Gene symbol | TCFL5 | Gene ID | 10732 |
Gene name | transcription factor like 5 | |
Gene Alias | CHA | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q86TP4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10732 | TCFL5 | HCC1_Meng | Human | Liver | HCC | 6.88e-15 | 1.81e-02 | 0.0246 |
10732 | TCFL5 | HCC2_Meng | Human | Liver | HCC | 5.98e-03 | 2.94e-02 | 0.0107 |
10732 | TCFL5 | HCC1 | Human | Liver | HCC | 2.43e-02 | 1.67e+00 | 0.5336 |
10732 | TCFL5 | HCC2 | Human | Liver | HCC | 1.02e-04 | 1.42e+00 | 0.5341 |
10732 | TCFL5 | S028 | Human | Liver | HCC | 8.47e-08 | 2.60e-01 | 0.2503 |
10732 | TCFL5 | male-WTA | Human | Thyroid | PTC | 1.49e-04 | 6.49e-02 | 0.1037 |
10732 | TCFL5 | PTC06 | Human | Thyroid | PTC | 2.76e-06 | 9.94e-02 | 0.2057 |
10732 | TCFL5 | ATC12 | Human | Thyroid | ATC | 9.43e-07 | 1.31e-01 | 0.34 |
10732 | TCFL5 | ATC13 | Human | Thyroid | ATC | 8.98e-25 | 5.00e-01 | 0.34 |
10732 | TCFL5 | ATC4 | Human | Thyroid | ATC | 1.36e-11 | 1.64e-01 | 0.34 |
10732 | TCFL5 | ATC5 | Human | Thyroid | ATC | 5.27e-33 | 5.59e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCFL5 | SNV | Missense_Mutation | rs779829916 | c.1043N>A | p.Arg348His | p.R348H | Q9UL49 | protein_coding | tolerated(0.44) | benign(0.007) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TCFL5 | SNV | Missense_Mutation | c.665G>A | p.Arg222Gln | p.R222Q | Q9UL49 | protein_coding | tolerated(0.06) | probably_damaging(0.978) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
TCFL5 | SNV | Missense_Mutation | rs780872850 | c.1297G>A | p.Glu433Lys | p.E433K | Q9UL49 | protein_coding | tolerated(0.13) | possibly_damaging(0.566) | TCGA-CD-5801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TCFL5 | SNV | Missense_Mutation | rs200910523 | c.1102G>C | p.Gly368Arg | p.G368R | Q9UL49 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-D7-A6EZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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