![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TCF7L1 |
Gene summary for TCF7L1 |
![]() |
Gene information | Species | Human | Gene symbol | TCF7L1 | Gene ID | 83439 |
Gene name | transcription factor 7 like 1 | |
Gene Alias | TCF-3 | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9HCS4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83439 | TCF7L1 | AEH-subject1 | Human | Endometrium | AEH | 2.35e-04 | 2.48e-01 | -0.3059 |
83439 | TCF7L1 | AEH-subject5 | Human | Endometrium | AEH | 1.26e-02 | 2.26e-01 | -0.2953 |
83439 | TCF7L1 | EEC-subject1 | Human | Endometrium | EEC | 1.32e-04 | 3.02e-01 | -0.2682 |
83439 | TCF7L1 | GSM5276935 | Human | Endometrium | EEC | 2.27e-03 | 1.63e-01 | -0.123 |
83439 | TCF7L1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 4.12e-06 | 1.63e-01 | -0.1869 |
83439 | TCF7L1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.58e-04 | 4.01e-02 | -0.1875 |
83439 | TCF7L1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.71e-07 | 8.74e-02 | -0.1883 |
83439 | TCF7L1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.73e-08 | 2.46e-01 | -0.1934 |
83439 | TCF7L1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.44e-12 | 9.36e-02 | -0.1917 |
83439 | TCF7L1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.81e-08 | 7.43e-02 | -0.1916 |
83439 | TCF7L1 | P2T-E | Human | Esophagus | ESCC | 7.50e-27 | 5.58e-01 | 0.1177 |
83439 | TCF7L1 | P4T-E | Human | Esophagus | ESCC | 7.88e-08 | 1.41e-01 | 0.1323 |
83439 | TCF7L1 | P5T-E | Human | Esophagus | ESCC | 6.36e-06 | 6.13e-02 | 0.1327 |
83439 | TCF7L1 | P8T-E | Human | Esophagus | ESCC | 6.46e-08 | 1.41e-01 | 0.0889 |
83439 | TCF7L1 | P9T-E | Human | Esophagus | ESCC | 3.65e-02 | 3.77e-02 | 0.1131 |
83439 | TCF7L1 | P10T-E | Human | Esophagus | ESCC | 5.64e-11 | 1.54e-01 | 0.116 |
83439 | TCF7L1 | P12T-E | Human | Esophagus | ESCC | 8.17e-30 | 3.97e-01 | 0.1122 |
83439 | TCF7L1 | P15T-E | Human | Esophagus | ESCC | 5.54e-08 | 2.05e-01 | 0.1149 |
83439 | TCF7L1 | P16T-E | Human | Esophagus | ESCC | 8.32e-31 | 5.60e-01 | 0.1153 |
83439 | TCF7L1 | P20T-E | Human | Esophagus | ESCC | 2.24e-06 | 9.14e-02 | 0.1124 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301118 | Endometrium | AEH | regulation of Wnt signaling pathway | 71/2100 | 328/18723 | 3.31e-08 | 1.87e-06 | 71 |
GO:00160558 | Endometrium | AEH | Wnt signaling pathway | 85/2100 | 444/18723 | 4.99e-07 | 1.97e-05 | 85 |
GO:01987388 | Endometrium | AEH | cell-cell signaling by wnt | 85/2100 | 446/18723 | 6.07e-07 | 2.29e-05 | 85 |
GO:00600708 | Endometrium | AEH | canonical Wnt signaling pathway | 58/2100 | 303/18723 | 3.12e-05 | 5.66e-04 | 58 |
GO:00063258 | Endometrium | AEH | chromatin organization | 64/2100 | 409/18723 | 3.69e-03 | 2.52e-02 | 64 |
GO:003011113 | Endometrium | EEC | regulation of Wnt signaling pathway | 74/2168 | 328/18723 | 1.03e-08 | 6.47e-07 | 74 |
GO:001605513 | Endometrium | EEC | Wnt signaling pathway | 90/2168 | 444/18723 | 6.65e-08 | 3.50e-06 | 90 |
GO:019873813 | Endometrium | EEC | cell-cell signaling by wnt | 90/2168 | 446/18723 | 8.25e-08 | 4.23e-06 | 90 |
GO:006007013 | Endometrium | EEC | canonical Wnt signaling pathway | 61/2168 | 303/18723 | 1.05e-05 | 2.25e-04 | 61 |
GO:000632513 | Endometrium | EEC | chromatin organization | 65/2168 | 409/18723 | 4.98e-03 | 3.14e-02 | 65 |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:003011117 | Esophagus | ESCC | regulation of Wnt signaling pathway | 194/8552 | 328/18723 | 5.39e-07 | 7.14e-06 | 194 |
GO:006007016 | Esophagus | ESCC | canonical Wnt signaling pathway | 180/8552 | 303/18723 | 9.15e-07 | 1.17e-05 | 180 |
GO:00160556 | Lung | IAC | Wnt signaling pathway | 95/2061 | 444/18723 | 1.13e-10 | 2.80e-08 | 95 |
GO:01987386 | Lung | IAC | cell-cell signaling by wnt | 95/2061 | 446/18723 | 1.46e-10 | 3.48e-08 | 95 |
GO:00301116 | Lung | IAC | regulation of Wnt signaling pathway | 74/2061 | 328/18723 | 1.14e-09 | 2.05e-07 | 74 |
GO:00600706 | Lung | IAC | canonical Wnt signaling pathway | 61/2061 | 303/18723 | 2.09e-06 | 9.45e-05 | 61 |
GO:00063256 | Lung | IAC | chromatin organization | 69/2061 | 409/18723 | 2.01e-04 | 3.53e-03 | 69 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513226 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa0452025 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa043909 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0521314 | Endometrium | AEH | Endometrial cancer | 18/1197 | 58/8465 | 7.42e-04 | 5.03e-03 | 3.68e-03 | 18 |
hsa0516725 | Endometrium | AEH | Kaposi sarcoma-associated herpesvirus infection | 44/1197 | 194/8465 | 7.97e-04 | 5.28e-03 | 3.87e-03 | 44 |
hsa052158 | Endometrium | AEH | Prostate cancer | 25/1197 | 97/8465 | 1.68e-03 | 1.01e-02 | 7.39e-03 | 25 |
hsa0521610 | Endometrium | AEH | Thyroid cancer | 12/1197 | 37/8465 | 3.68e-03 | 2.14e-02 | 1.56e-02 | 12 |
hsa0431010 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa05132112 | Endometrium | AEH | Salmonella infection | 71/1197 | 249/8465 | 1.69e-09 | 3.44e-08 | 2.52e-08 | 71 |
hsa04520111 | Endometrium | AEH | Adherens junction | 36/1197 | 93/8465 | 3.49e-09 | 5.98e-08 | 4.37e-08 | 36 |
hsa0439014 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0521315 | Endometrium | AEH | Endometrial cancer | 18/1197 | 58/8465 | 7.42e-04 | 5.03e-03 | 3.68e-03 | 18 |
hsa05167111 | Endometrium | AEH | Kaposi sarcoma-associated herpesvirus infection | 44/1197 | 194/8465 | 7.97e-04 | 5.28e-03 | 3.87e-03 | 44 |
hsa0521513 | Endometrium | AEH | Prostate cancer | 25/1197 | 97/8465 | 1.68e-03 | 1.01e-02 | 7.39e-03 | 25 |
hsa0521615 | Endometrium | AEH | Thyroid cancer | 12/1197 | 37/8465 | 3.68e-03 | 2.14e-02 | 1.56e-02 | 12 |
hsa0431013 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0513227 | Endometrium | EEC | Salmonella infection | 71/1237 | 249/8465 | 7.11e-09 | 1.30e-07 | 9.69e-08 | 71 |
hsa0452026 | Endometrium | EEC | Adherens junction | 36/1237 | 93/8465 | 8.57e-09 | 1.48e-07 | 1.11e-07 | 36 |
hsa0439023 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa0516726 | Endometrium | EEC | Kaposi sarcoma-associated herpesvirus infection | 45/1237 | 194/8465 | 8.55e-04 | 5.86e-03 | 4.37e-03 | 45 |
Page: 1 2 3 4 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 3 4 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TCF7L1 | SNV | Missense_Mutation | rs756969067 | c.1694C>T | p.Thr565Met | p.T565M | Q9HCS4 | protein_coding | tolerated_low_confidence(0.07) | benign(0.001) | TCGA-CG-4442-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TCF7L1 | SNV | Missense_Mutation | rs35802950 | c.500N>T | p.Thr167Met | p.T167M | Q9HCS4 | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
TCF7L1 | SNV | Missense_Mutation | rs764185209 | c.1542N>T | p.Gln514His | p.Q514H | Q9HCS4 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-F1-6177-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TCF7L1 | SNV | Missense_Mutation | novel | c.1435N>A | p.Pro479Thr | p.P479T | Q9HCS4 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
TCF7L1 | deletion | Frame_Shift_Del | c.961delN | p.Ser323AlafsTer2 | p.S323Afs*2 | Q9HCS4 | protein_coding | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
TCF7L1 | deletion | Frame_Shift_Del | c.961delN | p.Ser323AlafsTer2 | p.S323Afs*2 | Q9HCS4 | protein_coding | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |||
TCF7L1 | SNV | Missense_Mutation | c.1069A>T | p.Met357Leu | p.M357L | Q9HCS4 | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-EL-A3N3-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TCF7L1 | SNV | Missense_Mutation | c.642G>C | p.Glu214Asp | p.E214D | Q9HCS4 | protein_coding | tolerated(1) | possibly_damaging(0.492) | TCGA-EL-A3ZO-01 | Thyroid | thyroid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |