![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TBC1D4 |
Gene summary for TBC1D4 |
![]() |
Gene information | Species | Human | Gene symbol | TBC1D4 | Gene ID | 9882 |
Gene name | TBC1 domain family member 4 | |
Gene Alias | AS160 | |
Cytomap | 13q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O60343 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9882 | TBC1D4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.24e-11 | -5.70e-01 | 0.0155 |
9882 | TBC1D4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.57e-03 | -5.19e-01 | -0.1808 |
9882 | TBC1D4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.40e-05 | -8.35e-01 | 0.0216 |
9882 | TBC1D4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.92e-04 | -5.89e-01 | -0.1207 |
9882 | TBC1D4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.43e-07 | -3.90e-01 | -0.1464 |
9882 | TBC1D4 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.23e-06 | -4.09e-01 | -0.1001 |
9882 | TBC1D4 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.42e-03 | -6.51e-01 | 0.0528 |
9882 | TBC1D4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.54e-04 | -5.23e-01 | 0.0338 |
9882 | TBC1D4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.27e-02 | -3.37e-01 | 0.0674 |
9882 | TBC1D4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.06e-03 | -5.69e-01 | 0.0588 |
9882 | TBC1D4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.62e-03 | -2.26e-01 | 0.294 |
9882 | TBC1D4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.11e-08 | 6.90e-01 | 0.281 |
9882 | TBC1D4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.59e-13 | -4.84e-01 | 0.3005 |
9882 | TBC1D4 | A002-C-010 | Human | Colorectum | FAP | 2.42e-05 | -1.91e-01 | 0.242 |
9882 | TBC1D4 | A001-C-207 | Human | Colorectum | FAP | 9.09e-03 | -2.85e-01 | 0.1278 |
9882 | TBC1D4 | A015-C-203 | Human | Colorectum | FAP | 2.03e-24 | -3.07e-01 | -0.1294 |
9882 | TBC1D4 | A015-C-204 | Human | Colorectum | FAP | 9.43e-05 | -3.17e-01 | -0.0228 |
9882 | TBC1D4 | A014-C-040 | Human | Colorectum | FAP | 4.83e-03 | -4.04e-01 | -0.1184 |
9882 | TBC1D4 | A002-C-201 | Human | Colorectum | FAP | 3.17e-14 | -4.93e-01 | 0.0324 |
9882 | TBC1D4 | A002-C-203 | Human | Colorectum | FAP | 6.73e-07 | -2.94e-01 | 0.2786 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0016050 | Colorectum | AD | vesicle organization | 101/3918 | 300/18723 | 1.65e-07 | 7.17e-06 | 101 |
GO:0032868 | Colorectum | AD | response to insulin | 91/3918 | 264/18723 | 2.02e-07 | 8.48e-06 | 91 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0032869 | Colorectum | AD | cellular response to insulin stimulus | 72/3918 | 203/18723 | 1.10e-06 | 3.68e-05 | 72 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:0048284 | Colorectum | AD | organelle fusion | 42/3918 | 141/18723 | 8.04e-03 | 4.73e-02 | 42 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:00328681 | Colorectum | SER | response to insulin | 65/2897 | 264/18723 | 6.70e-05 | 1.53e-03 | 65 |
GO:19016531 | Colorectum | SER | cellular response to peptide | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:00434341 | Colorectum | SER | response to peptide hormone | 93/2897 | 414/18723 | 9.61e-05 | 2.04e-03 | 93 |
GO:00713751 | Colorectum | SER | cellular response to peptide hormone stimulus | 68/2897 | 290/18723 | 2.20e-04 | 3.89e-03 | 68 |
GO:00328691 | Colorectum | SER | cellular response to insulin stimulus | 51/2897 | 203/18723 | 2.30e-04 | 3.96e-03 | 51 |
GO:00160501 | Colorectum | SER | vesicle organization | 69/2897 | 300/18723 | 3.59e-04 | 5.61e-03 | 69 |
GO:00430871 | Colorectum | SER | regulation of GTPase activity | 77/2897 | 348/18723 | 5.90e-04 | 8.07e-03 | 77 |
GO:0051051 | Colorectum | SER | negative regulation of transport | 98/2897 | 470/18723 | 1.01e-03 | 1.19e-02 | 98 |
GO:00160502 | Colorectum | MSS | vesicle organization | 93/3467 | 300/18723 | 1.04e-07 | 4.97e-06 | 93 |
Page: 1 2 3 4 5 6 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05415 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa04919 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa054151 | Colorectum | AD | Diabetic cardiomyopathy | 114/2092 | 203/8465 | 3.65e-22 | 3.06e-20 | 1.95e-20 | 114 |
hsa049191 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa054152 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa049192 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa054153 | Colorectum | SER | Diabetic cardiomyopathy | 103/1580 | 203/8465 | 1.45e-25 | 1.61e-23 | 1.17e-23 | 103 |
hsa049193 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa054154 | Colorectum | MSS | Diabetic cardiomyopathy | 106/1875 | 203/8465 | 2.47e-21 | 1.62e-19 | 9.92e-20 | 106 |
hsa049194 | Colorectum | MSS | Thyroid hormone signaling pathway | 46/1875 | 121/8465 | 5.04e-05 | 4.97e-04 | 3.05e-04 | 46 |
hsa04931 | Colorectum | MSS | Insulin resistance | 36/1875 | 108/8465 | 4.74e-03 | 2.01e-02 | 1.23e-02 | 36 |
hsa054155 | Colorectum | MSS | Diabetic cardiomyopathy | 106/1875 | 203/8465 | 2.47e-21 | 1.62e-19 | 9.92e-20 | 106 |
hsa049195 | Colorectum | MSS | Thyroid hormone signaling pathway | 46/1875 | 121/8465 | 5.04e-05 | 4.97e-04 | 3.05e-04 | 46 |
hsa049311 | Colorectum | MSS | Insulin resistance | 36/1875 | 108/8465 | 4.74e-03 | 2.01e-02 | 1.23e-02 | 36 |
hsa054158 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
hsa049198 | Colorectum | FAP | Thyroid hormone signaling pathway | 41/1404 | 121/8465 | 2.28e-06 | 4.28e-05 | 2.60e-05 | 41 |
hsa049312 | Colorectum | FAP | Insulin resistance | 32/1404 | 108/8465 | 4.90e-04 | 3.56e-03 | 2.16e-03 | 32 |
hsa054159 | Colorectum | FAP | Diabetic cardiomyopathy | 70/1404 | 203/8465 | 2.62e-10 | 2.18e-08 | 1.33e-08 | 70 |
hsa049199 | Colorectum | FAP | Thyroid hormone signaling pathway | 41/1404 | 121/8465 | 2.28e-06 | 4.28e-05 | 2.60e-05 | 41 |
hsa049313 | Colorectum | FAP | Insulin resistance | 32/1404 | 108/8465 | 4.90e-04 | 3.56e-03 | 2.16e-03 | 32 |
Page: 1 2 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D4 | SNV | Missense_Mutation | c.2996N>A | p.Ser999Tyr | p.S999Y | O60343 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TBC1D4 | SNV | Missense_Mutation | novel | c.1636N>A | p.Glu546Lys | p.E546K | O60343 | protein_coding | tolerated(0.07) | benign(0.352) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TBC1D4 | SNV | Missense_Mutation | novel | c.183N>T | p.Glu61Asp | p.E61D | O60343 | protein_coding | deleterious(0) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TBC1D4 | SNV | Missense_Mutation | novel | c.1730G>A | p.Arg577Lys | p.R577K | O60343 | protein_coding | tolerated(0.24) | benign(0.015) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBC1D4 | SNV | Missense_Mutation | novel | c.1525N>A | p.Glu509Lys | p.E509K | O60343 | protein_coding | tolerated(0.22) | benign(0.124) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D4 | SNV | Missense_Mutation | rs760528845 | c.1267N>A | p.Glu423Lys | p.E423K | O60343 | protein_coding | deleterious(0) | possibly_damaging(0.69) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D4 | SNV | Missense_Mutation | novel | c.1007N>A | p.Arg336Gln | p.R336Q | O60343 | protein_coding | tolerated(0.31) | probably_damaging(0.997) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D4 | SNV | Missense_Mutation | c.3814G>A | p.Asp1272Asn | p.D1272N | O60343 | protein_coding | deleterious(0.04) | benign(0.025) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TBC1D4 | SNV | Missense_Mutation | rs767493446 | c.3149C>T | p.Ser1050Leu | p.S1050L | O60343 | protein_coding | tolerated(0.14) | probably_damaging(0.995) | TCGA-AP-A0LG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TBC1D4 | SNV | Missense_Mutation | c.2838N>T | p.Gln946His | p.Q946H | O60343 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |