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Gene: TBC1D19 |
Gene summary for TBC1D19 |
Gene summary. |
Gene information | Species | Human | Gene symbol | TBC1D19 | Gene ID | 55296 |
Gene name | TBC1 domain family member 19 | |
Gene Alias | TBC1D19 | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8N5T2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55296 | TBC1D19 | P2T-E | Human | Esophagus | ESCC | 2.93e-15 | 2.59e-01 | 0.1177 |
55296 | TBC1D19 | P5T-E | Human | Esophagus | ESCC | 5.33e-05 | 3.59e-02 | 0.1327 |
55296 | TBC1D19 | P8T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.59e-01 | 0.0889 |
55296 | TBC1D19 | P9T-E | Human | Esophagus | ESCC | 3.05e-03 | 1.01e-01 | 0.1131 |
55296 | TBC1D19 | P10T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.34e-01 | 0.116 |
55296 | TBC1D19 | P11T-E | Human | Esophagus | ESCC | 1.13e-06 | 2.17e-01 | 0.1426 |
55296 | TBC1D19 | P12T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.03e-01 | 0.1122 |
55296 | TBC1D19 | P15T-E | Human | Esophagus | ESCC | 3.26e-02 | 6.68e-02 | 0.1149 |
55296 | TBC1D19 | P16T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.65e-01 | 0.1153 |
55296 | TBC1D19 | P20T-E | Human | Esophagus | ESCC | 2.18e-03 | 8.76e-02 | 0.1124 |
55296 | TBC1D19 | P21T-E | Human | Esophagus | ESCC | 7.74e-41 | 7.86e-01 | 0.1617 |
55296 | TBC1D19 | P22T-E | Human | Esophagus | ESCC | 3.90e-16 | 1.28e-01 | 0.1236 |
55296 | TBC1D19 | P26T-E | Human | Esophagus | ESCC | 3.50e-02 | 6.24e-02 | 0.1276 |
55296 | TBC1D19 | P27T-E | Human | Esophagus | ESCC | 1.68e-08 | 7.85e-02 | 0.1055 |
55296 | TBC1D19 | P30T-E | Human | Esophagus | ESCC | 2.31e-10 | 2.86e-01 | 0.137 |
55296 | TBC1D19 | P32T-E | Human | Esophagus | ESCC | 3.75e-03 | 7.89e-02 | 0.1666 |
55296 | TBC1D19 | P37T-E | Human | Esophagus | ESCC | 3.53e-03 | 8.78e-02 | 0.1371 |
55296 | TBC1D19 | P42T-E | Human | Esophagus | ESCC | 9.05e-04 | 1.15e-01 | 0.1175 |
55296 | TBC1D19 | P47T-E | Human | Esophagus | ESCC | 1.41e-03 | 5.23e-02 | 0.1067 |
55296 | TBC1D19 | P48T-E | Human | Esophagus | ESCC | 3.97e-04 | 8.42e-02 | 0.0959 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TBC1D19 | SNV | Missense_Mutation | novel | c.1088T>G | p.Val363Gly | p.V363G | Q8N5T2 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TBC1D19 | SNV | Missense_Mutation | novel | c.524N>A | p.Ser175Tyr | p.S175Y | Q8N5T2 | protein_coding | deleterious(0.03) | benign(0.009) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TBC1D19 | SNV | Missense_Mutation | c.183N>T | p.Lys61Asn | p.K61N | Q8N5T2 | protein_coding | tolerated(0.13) | benign(0.006) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D19 | SNV | Missense_Mutation | novel | c.311N>T | p.Arg104Ile | p.R104I | Q8N5T2 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-QS-A5YQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TBC1D19 | deletion | Frame_Shift_Del | novel | c.50delN | p.Lys18SerfsTer29 | p.K18Sfs*29 | Q8N5T2 | protein_coding | TCGA-BK-A13B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
TBC1D19 | SNV | Missense_Mutation | c.795N>C | p.Leu265Phe | p.L265F | Q8N5T2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-05-5715-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TBC1D19 | SNV | Missense_Mutation | novel | c.481G>T | p.Val161Leu | p.V161L | Q8N5T2 | protein_coding | deleterious(0) | benign(0.098) | TCGA-64-5775-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD |
TBC1D19 | SNV | Missense_Mutation | novel | c.100N>T | p.Ala34Ser | p.A34S | Q8N5T2 | protein_coding | tolerated(0.71) | benign(0) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
TBC1D19 | SNV | Missense_Mutation | novel | c.1054N>C | p.Glu352Gln | p.E352Q | Q8N5T2 | protein_coding | tolerated(0.24) | benign(0.014) | TCGA-78-7146-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TBC1D19 | SNV | Missense_Mutation | novel | c.640N>T | p.Asp214Tyr | p.D214Y | Q8N5T2 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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