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Gene: TACC2 |
Gene summary for TACC2 |
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Gene information | Species | Human | Gene symbol | TACC2 | Gene ID | 10579 |
Gene name | transforming acidic coiled-coil containing protein 2 | |
Gene Alias | AZU-1 | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | B2RWP4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10579 | TACC2 | CA_HPV_1 | Human | Cervix | CC | 1.88e-05 | -1.05e-01 | 0.0264 |
10579 | TACC2 | CCI_1 | Human | Cervix | CC | 5.47e-15 | 1.28e+00 | 0.528 |
10579 | TACC2 | CCI_2 | Human | Cervix | CC | 3.24e-14 | 9.87e-01 | 0.5249 |
10579 | TACC2 | CCI_3 | Human | Cervix | CC | 4.91e-14 | 8.51e-01 | 0.516 |
10579 | TACC2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.07e-05 | -1.71e-01 | 0.0155 |
10579 | TACC2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.29e-07 | 4.90e-01 | -0.1954 |
10579 | TACC2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.88e-06 | 7.49e-01 | 0.3859 |
10579 | TACC2 | A015-C-203 | Human | Colorectum | FAP | 2.98e-24 | -1.80e-01 | -0.1294 |
10579 | TACC2 | A015-C-204 | Human | Colorectum | FAP | 4.40e-04 | -1.28e-01 | -0.0228 |
10579 | TACC2 | A014-C-040 | Human | Colorectum | FAP | 6.28e-03 | -1.26e-01 | -0.1184 |
10579 | TACC2 | A002-C-201 | Human | Colorectum | FAP | 2.87e-11 | -2.65e-01 | 0.0324 |
10579 | TACC2 | A002-C-203 | Human | Colorectum | FAP | 9.28e-04 | 6.05e-02 | 0.2786 |
10579 | TACC2 | A001-C-119 | Human | Colorectum | FAP | 1.92e-05 | 3.34e-02 | -0.1557 |
10579 | TACC2 | A001-C-108 | Human | Colorectum | FAP | 6.71e-13 | 2.93e-03 | -0.0272 |
10579 | TACC2 | A002-C-205 | Human | Colorectum | FAP | 3.19e-21 | -5.97e-02 | -0.1236 |
10579 | TACC2 | A001-C-104 | Human | Colorectum | FAP | 2.43e-02 | 6.99e-02 | 0.0184 |
10579 | TACC2 | A015-C-006 | Human | Colorectum | FAP | 7.83e-14 | -2.99e-01 | -0.0994 |
10579 | TACC2 | A015-C-106 | Human | Colorectum | FAP | 5.14e-08 | -2.68e-02 | -0.0511 |
10579 | TACC2 | A002-C-114 | Human | Colorectum | FAP | 1.17e-14 | -1.31e-01 | -0.1561 |
10579 | TACC2 | A015-C-104 | Human | Colorectum | FAP | 6.40e-28 | -2.07e-01 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00219873 | Cervix | CC | cerebral cortex development | 25/2311 | 114/18723 | 2.81e-03 | 1.88e-02 | 25 |
GO:00309003 | Cervix | CC | forebrain development | 64/2311 | 379/18723 | 5.53e-03 | 3.19e-02 | 64 |
GO:00215433 | Cervix | CC | pallium development | 32/2311 | 169/18723 | 8.73e-03 | 4.48e-02 | 32 |
GO:0007051 | Colorectum | AD | spindle organization | 58/3918 | 184/18723 | 4.71e-04 | 5.20e-03 | 58 |
GO:1902850 | Colorectum | AD | microtubule cytoskeleton organization involved in mitosis | 48/3918 | 147/18723 | 5.87e-04 | 6.21e-03 | 48 |
GO:0007052 | Colorectum | AD | mitotic spindle organization | 40/3918 | 120/18723 | 1.03e-03 | 9.61e-03 | 40 |
GO:00070511 | Colorectum | MSS | spindle organization | 53/3467 | 184/18723 | 4.23e-04 | 5.19e-03 | 53 |
GO:19028501 | Colorectum | MSS | microtubule cytoskeleton organization involved in mitosis | 44/3467 | 147/18723 | 5.17e-04 | 5.98e-03 | 44 |
GO:00070521 | Colorectum | MSS | mitotic spindle organization | 36/3467 | 120/18723 | 1.52e-03 | 1.39e-02 | 36 |
GO:00070512 | Colorectum | FAP | spindle organization | 41/2622 | 184/18723 | 1.50e-03 | 1.34e-02 | 41 |
GO:0021987 | Colorectum | FAP | cerebral cortex development | 28/2622 | 114/18723 | 1.80e-03 | 1.55e-02 | 28 |
GO:0021543 | Colorectum | FAP | pallium development | 36/2622 | 169/18723 | 6.06e-03 | 3.81e-02 | 36 |
GO:0030900 | Colorectum | FAP | forebrain development | 70/2622 | 379/18723 | 8.64e-03 | 4.98e-02 | 70 |
GO:00309001 | Colorectum | CRC | forebrain development | 66/2078 | 379/18723 | 1.36e-04 | 2.57e-03 | 66 |
GO:00219871 | Colorectum | CRC | cerebral cortex development | 24/2078 | 114/18723 | 1.45e-03 | 1.57e-02 | 24 |
GO:00215431 | Colorectum | CRC | pallium development | 32/2078 | 169/18723 | 1.74e-03 | 1.79e-02 | 32 |
GO:0021537 | Colorectum | CRC | telencephalon development | 43/2078 | 248/18723 | 2.01e-03 | 2.01e-02 | 43 |
GO:00070513 | Colorectum | CRC | spindle organization | 32/2078 | 184/18723 | 6.70e-03 | 4.77e-02 | 32 |
GO:19028504 | Endometrium | AEH | microtubule cytoskeleton organization involved in mitosis | 28/2100 | 147/18723 | 3.46e-03 | 2.39e-02 | 28 |
GO:00070524 | Endometrium | AEH | mitotic spindle organization | 23/2100 | 120/18723 | 7.01e-03 | 4.07e-02 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TACC2 | SNV | Missense_Mutation | novel | c.8683N>T | p.Val2895Phe | p.V2895F | O95359 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TACC2 | SNV | Missense_Mutation | c.3925N>A | p.Ala1309Thr | p.A1309T | O95359 | protein_coding | tolerated(0.07) | benign(0.006) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TACC2 | SNV | Missense_Mutation | novel | c.6883G>A | p.Ala2295Thr | p.A2295T | O95359 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-AA-3850-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TACC2 | SNV | Missense_Mutation | c.2260G>T | p.Gly754Cys | p.G754C | O95359 | protein_coding | deleterious(0) | benign(0.028) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TACC2 | SNV | Missense_Mutation | novel | c.6271N>A | p.Ala2091Thr | p.A2091T | O95359 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TACC2 | SNV | Missense_Mutation | rs567347253 | c.8062N>T | p.Arg2688Trp | p.R2688W | O95359 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TACC2 | SNV | Missense_Mutation | c.2180N>A | p.Pro727His | p.P727H | O95359 | protein_coding | deleterious(0) | possibly_damaging(0.707) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TACC2 | SNV | Missense_Mutation | rs769043605 | c.4585N>A | p.Glu1529Lys | p.E1529K | O95359 | protein_coding | tolerated_low_confidence(0.27) | benign(0.013) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TACC2 | SNV | Missense_Mutation | c.8818N>A | p.Glu2940Lys | p.E2940K | O95359 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TACC2 | SNV | Missense_Mutation | c.2495N>T | p.Pro832Leu | p.P832L | O95359 | protein_coding | deleterious(0) | benign(0.006) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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