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Gene: SUPT16H |
Gene summary for SUPT16H |
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Gene information | Species | Human | Gene symbol | SUPT16H | Gene ID | 11198 |
Gene name | SPT16 homolog, facilitates chromatin remodeling subunit | |
Gene Alias | CDC68 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y5B9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11198 | SUPT16H | HTA11_347_2000001011 | Human | Colorectum | AD | 9.98e-11 | 4.49e-01 | -0.1954 |
11198 | SUPT16H | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.85e-09 | 6.42e-01 | -0.059 |
11198 | SUPT16H | HTA11_866_3004761011 | Human | Colorectum | AD | 3.68e-03 | 3.29e-01 | 0.096 |
11198 | SUPT16H | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.20e-05 | 4.25e-01 | 0.294 |
11198 | SUPT16H | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.50e-10 | 6.49e-01 | 0.281 |
11198 | SUPT16H | A015-C-203 | Human | Colorectum | FAP | 2.46e-06 | 5.18e-02 | -0.1294 |
11198 | SUPT16H | A015-C-104 | Human | Colorectum | FAP | 2.36e-08 | 1.99e-02 | -0.1899 |
11198 | SUPT16H | A001-C-014 | Human | Colorectum | FAP | 1.49e-02 | -3.51e-02 | 0.0135 |
11198 | SUPT16H | A002-C-016 | Human | Colorectum | FAP | 4.71e-03 | -1.76e-02 | 0.0521 |
11198 | SUPT16H | A002-C-116 | Human | Colorectum | FAP | 4.76e-06 | -7.64e-03 | -0.0452 |
11198 | SUPT16H | LZE2D | Human | Esophagus | HGIN | 2.31e-03 | 3.57e-01 | 0.0642 |
11198 | SUPT16H | LZE2T | Human | Esophagus | ESCC | 1.30e-07 | 1.12e+00 | 0.082 |
11198 | SUPT16H | LZE4T | Human | Esophagus | ESCC | 8.41e-22 | 7.83e-01 | 0.0811 |
11198 | SUPT16H | LZE5T | Human | Esophagus | ESCC | 2.20e-08 | 1.05e+00 | 0.0514 |
11198 | SUPT16H | LZE7T | Human | Esophagus | ESCC | 3.11e-05 | 3.92e-01 | 0.0667 |
11198 | SUPT16H | LZE8T | Human | Esophagus | ESCC | 7.60e-07 | 2.28e-01 | 0.067 |
11198 | SUPT16H | LZE20T | Human | Esophagus | ESCC | 8.75e-12 | 2.80e-01 | 0.0662 |
11198 | SUPT16H | LZE21D1 | Human | Esophagus | HGIN | 4.62e-05 | 2.02e-01 | 0.0632 |
11198 | SUPT16H | LZE22D1 | Human | Esophagus | HGIN | 1.61e-02 | 9.07e-02 | 0.0595 |
11198 | SUPT16H | LZE24T | Human | Esophagus | ESCC | 1.05e-18 | 3.72e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0032986 | Colorectum | AD | protein-DNA complex disassembly | 12/3918 | 20/18723 | 1.60e-04 | 2.21e-03 | 12 |
GO:0031498 | Colorectum | AD | chromatin disassembly | 11/3918 | 20/18723 | 8.39e-04 | 8.21e-03 | 11 |
GO:0006337 | Colorectum | AD | nucleosome disassembly | 10/3918 | 18/18723 | 1.31e-03 | 1.15e-02 | 10 |
GO:0032786 | Colorectum | AD | positive regulation of DNA-templated transcription, elongation | 13/3918 | 27/18723 | 1.47e-03 | 1.25e-02 | 13 |
GO:0006354 | Colorectum | AD | DNA-templated transcription, elongation | 31/3918 | 91/18723 | 2.46e-03 | 1.90e-02 | 31 |
GO:0006368 | Colorectum | AD | transcription elongation from RNA polymerase II promoter | 24/3918 | 69/18723 | 5.35e-03 | 3.52e-02 | 24 |
GO:0006338 | Colorectum | AD | chromatin remodeling | 70/3918 | 255/18723 | 7.44e-03 | 4.53e-02 | 70 |
GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
GO:00329842 | Colorectum | MSS | protein-containing complex disassembly | 69/3467 | 224/18723 | 5.61e-06 | 1.50e-04 | 69 |
GO:00329862 | Colorectum | MSS | protein-DNA complex disassembly | 12/3467 | 20/18723 | 4.55e-05 | 8.35e-04 | 12 |
GO:00063252 | Colorectum | MSS | chromatin organization | 107/3467 | 409/18723 | 7.22e-05 | 1.21e-03 | 107 |
GO:00314982 | Colorectum | MSS | chromatin disassembly | 11/3467 | 20/18723 | 2.77e-04 | 3.67e-03 | 11 |
GO:00063371 | Colorectum | MSS | nucleosome disassembly | 10/3467 | 18/18723 | 4.76e-04 | 5.58e-03 | 10 |
GO:00063541 | Colorectum | MSS | DNA-templated transcription, elongation | 29/3467 | 91/18723 | 1.52e-03 | 1.39e-02 | 29 |
GO:00327861 | Colorectum | MSS | positive regulation of DNA-templated transcription, elongation | 12/3467 | 27/18723 | 1.74e-03 | 1.55e-02 | 12 |
GO:00063681 | Colorectum | MSS | transcription elongation from RNA polymerase II promoter | 22/3467 | 69/18723 | 5.31e-03 | 3.62e-02 | 22 |
GO:00224114 | Colorectum | FAP | cellular component disassembly | 97/2622 | 443/18723 | 3.44e-06 | 1.23e-04 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUPT16H | deletion | Frame_Shift_Del | c.1178delN | p.Lys393SerfsTer29 | p.K393Sfs*29 | Q9Y5B9 | protein_coding | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
SUPT16H | deletion | Frame_Shift_Del | c.1178delN | p.Lys393SerfsTer29 | p.K393Sfs*29 | Q9Y5B9 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
SUPT16H | SNV | Missense_Mutation | novel | c.2606C>T | p.Thr869Ile | p.T869I | Q9Y5B9 | protein_coding | tolerated(0.07) | benign(0.268) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SUPT16H | SNV | Missense_Mutation | novel | c.862N>T | p.Arg288Cys | p.R288C | Q9Y5B9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SUPT16H | SNV | Missense_Mutation | c.1610C>T | p.Thr537Ile | p.T537I | Q9Y5B9 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SUPT16H | SNV | Missense_Mutation | novel | c.2087A>G | p.Lys696Arg | p.K696R | Q9Y5B9 | protein_coding | tolerated(0.25) | benign(0.288) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUPT16H | SNV | Missense_Mutation | novel | c.1149C>A | p.Phe383Leu | p.F383L | Q9Y5B9 | protein_coding | tolerated(0.58) | benign(0.01) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUPT16H | SNV | Missense_Mutation | novel | c.2960N>T | p.Gly987Val | p.G987V | Q9Y5B9 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
SUPT16H | SNV | Missense_Mutation | rs781334536 | c.3097C>T | p.Arg1033Cys | p.R1033C | Q9Y5B9 | protein_coding | deleterious(0) | benign(0.265) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUPT16H | SNV | Missense_Mutation | c.76G>A | p.Asp26Asn | p.D26N | Q9Y5B9 | protein_coding | tolerated(0.2) | benign(0.012) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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