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Gene: SULT1B1 |
Gene summary for SULT1B1 |
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Gene information | Species | Human | Gene symbol | SULT1B1 | Gene ID | 27284 |
Gene name | sulfotransferase family 1B member 1 | |
Gene Alias | ST1B1 | |
Cytomap | 4q13.3 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | O43704 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27284 | SULT1B1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.75e-11 | -4.94e-01 | 0.0155 |
27284 | SULT1B1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.20e-03 | 4.38e-01 | -0.1954 |
27284 | SULT1B1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.39e-02 | -4.42e-01 | -0.1207 |
27284 | SULT1B1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.22e-04 | -3.65e-01 | 0.096 |
27284 | SULT1B1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.97e-02 | -4.10e-01 | 0.0338 |
27284 | SULT1B1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.37e-02 | -3.22e-01 | 0.294 |
27284 | SULT1B1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.37e-04 | -4.22e-01 | 0.3859 |
27284 | SULT1B1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.27e-03 | -5.00e-01 | 0.2585 |
27284 | SULT1B1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.74e-17 | -5.33e-01 | 0.3005 |
27284 | SULT1B1 | A015-C-203 | Human | Colorectum | FAP | 1.78e-15 | -1.62e-01 | -0.1294 |
27284 | SULT1B1 | A002-C-201 | Human | Colorectum | FAP | 2.38e-05 | -7.86e-02 | 0.0324 |
27284 | SULT1B1 | A001-C-119 | Human | Colorectum | FAP | 7.34e-03 | -2.03e-01 | -0.1557 |
27284 | SULT1B1 | A001-C-108 | Human | Colorectum | FAP | 3.71e-06 | -5.48e-02 | -0.0272 |
27284 | SULT1B1 | A002-C-205 | Human | Colorectum | FAP | 5.90e-11 | -2.66e-01 | -0.1236 |
27284 | SULT1B1 | A015-C-006 | Human | Colorectum | FAP | 2.37e-08 | -3.00e-01 | -0.0994 |
27284 | SULT1B1 | A015-C-106 | Human | Colorectum | FAP | 1.59e-03 | -1.53e-01 | -0.0511 |
27284 | SULT1B1 | A002-C-114 | Human | Colorectum | FAP | 4.31e-08 | -1.45e-01 | -0.1561 |
27284 | SULT1B1 | A015-C-104 | Human | Colorectum | FAP | 2.78e-15 | -1.88e-01 | -0.1899 |
27284 | SULT1B1 | A001-C-014 | Human | Colorectum | FAP | 4.17e-06 | -1.11e-01 | 0.0135 |
27284 | SULT1B1 | A002-C-016 | Human | Colorectum | FAP | 6.43e-09 | 5.24e-02 | 0.0521 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0009410 | Colorectum | AD | response to xenobiotic stimulus | 128/3918 | 462/18723 | 2.69e-04 | 3.31e-03 | 128 |
GO:0006575 | Colorectum | AD | cellular modified amino acid metabolic process | 59/3918 | 188/18723 | 4.80e-04 | 5.27e-03 | 59 |
GO:0034310 | Colorectum | AD | primary alcohol catabolic process | 9/3918 | 15/18723 | 1.11e-03 | 1.01e-02 | 9 |
GO:0033865 | Colorectum | AD | nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
GO:0033875 | Colorectum | AD | ribonucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
GO:0034032 | Colorectum | AD | purine nucleoside bisphosphate metabolic process | 42/3918 | 128/18723 | 1.12e-03 | 1.02e-02 | 42 |
GO:0034308 | Colorectum | AD | primary alcohol metabolic process | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
GO:0006067 | Colorectum | AD | ethanol metabolic process | 11/3918 | 21/18723 | 1.43e-03 | 1.22e-02 | 11 |
GO:0034035 | Colorectum | AD | purine ribonucleoside bisphosphate metabolic process | 11/3918 | 21/18723 | 1.43e-03 | 1.22e-02 | 11 |
GO:0050427 | Colorectum | AD | 3'-phosphoadenosine 5'-phosphosulfate metabolic process | 11/3918 | 21/18723 | 1.43e-03 | 1.22e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SULT1B1 | SNV | Missense_Mutation | c.597N>T | p.Glu199Asp | p.E199D | O43704 | protein_coding | deleterious(0) | benign(0.056) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SULT1B1 | SNV | Missense_Mutation | c.733N>A | p.Pro245Thr | p.P245T | O43704 | protein_coding | deleterious(0.01) | possibly_damaging(0.658) | TCGA-44-6778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SULT1B1 | SNV | Missense_Mutation | c.626T>A | p.Ile209Asn | p.I209N | O43704 | protein_coding | deleterious(0.01) | benign(0.146) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SULT1B1 | SNV | Missense_Mutation | novel | c.876C>G | p.Phe292Leu | p.F292L | O43704 | protein_coding | deleterious(0.05) | possibly_damaging(0.825) | TCGA-55-1592-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SULT1B1 | SNV | Missense_Mutation | c.652N>T | p.Asp218Tyr | p.D218Y | O43704 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-75-7027-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
SULT1B1 | SNV | Missense_Mutation | c.311N>T | p.Arg104Leu | p.R104L | O43704 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD | |
SULT1B1 | SNV | Missense_Mutation | novel | c.667A>T | p.Arg223Trp | p.R223W | O43704 | protein_coding | deleterious(0) | possibly_damaging(0.842) | TCGA-22-A5C4-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SULT1B1 | SNV | Missense_Mutation | novel | c.681C>A | p.His227Gln | p.H227Q | O43704 | protein_coding | deleterious(0.03) | benign(0.332) | TCGA-33-AASB-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SULT1B1 | SNV | Missense_Mutation | c.139C>A | p.Pro47Thr | p.P47T | O43704 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-37-5819-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SULT1B1 | SNV | Missense_Mutation | c.518N>C | p.Trp173Ser | p.W173S | O43704 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-43-5668-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Other, specify in notesMAGE3-AS15-NSC-003 | clinical | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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