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Gene: STAMBPL1 |
Gene summary for STAMBPL1 |
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Gene information | Species | Human | Gene symbol | STAMBPL1 | Gene ID | 57559 |
Gene name | STAM binding protein like 1 | |
Gene Alias | ALMalpha | |
Cytomap | 10q23.31 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96FJ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57559 | STAMBPL1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.52e-12 | -5.51e-01 | 0.0155 |
57559 | STAMBPL1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.01e-10 | -6.41e-01 | -0.1808 |
57559 | STAMBPL1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.65e-02 | -4.01e-01 | -0.0811 |
57559 | STAMBPL1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.20e-05 | -3.82e-01 | -0.1954 |
57559 | STAMBPL1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.14e-02 | -7.10e-01 | -0.2602 |
57559 | STAMBPL1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.13e-09 | -6.60e-01 | -0.1207 |
57559 | STAMBPL1 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.43e-03 | -5.47e-01 | -0.1526 |
57559 | STAMBPL1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.16e-22 | -6.08e-01 | -0.1464 |
57559 | STAMBPL1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.51e-11 | -4.62e-01 | -0.1001 |
57559 | STAMBPL1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.59e-03 | -4.12e-01 | -0.059 |
57559 | STAMBPL1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.77e-02 | -6.53e-01 | -0.1706 |
57559 | STAMBPL1 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.20e-04 | -5.74e-01 | -0.0842 |
57559 | STAMBPL1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.35e-10 | -5.27e-01 | 0.096 |
57559 | STAMBPL1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.97e-02 | -5.92e-01 | 0.0528 |
57559 | STAMBPL1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.17e-06 | -5.27e-01 | 0.0338 |
57559 | STAMBPL1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.23e-16 | -5.29e-01 | 0.0674 |
57559 | STAMBPL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.67e-20 | -5.79e-01 | 0.294 |
57559 | STAMBPL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.91e-05 | -3.60e-01 | 0.3859 |
57559 | STAMBPL1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.70e-05 | -6.30e-01 | 0.2585 |
57559 | STAMBPL1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.16e-27 | -6.39e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00706461 | Liver | HCC | protein modification by small protein removal | 91/7958 | 157/18723 | 6.50e-05 | 5.92e-04 | 91 |
GO:00165791 | Liver | HCC | protein deubiquitination | 78/7958 | 139/18723 | 8.13e-04 | 4.87e-03 | 78 |
GO:00705361 | Liver | HCC | protein K63-linked deubiquitination | 24/7958 | 35/18723 | 1.64e-03 | 8.61e-03 | 24 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STAMBPL1 | SNV | Missense_Mutation | novel | c.211N>A | p.Leu71Met | p.L71M | Q96FJ0 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-CR-7395-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STAMBPL1 | SNV | Missense_Mutation | novel | c.128N>T | p.Ser43Ile | p.S43I | Q96FJ0 | protein_coding | deleterious(0) | benign(0.009) | TCGA-CV-A461-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
STAMBPL1 | SNV | Missense_Mutation | novel | c.501N>A | p.Met167Ile | p.M167I | Q96FJ0 | protein_coding | tolerated(0.15) | benign(0.001) | TCGA-TP-A8TV-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
STAMBPL1 | SNV | Missense_Mutation | novel | c.502N>G | p.Arg168Gly | p.R168G | Q96FJ0 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-TP-A8TV-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
STAMBPL1 | SNV | Missense_Mutation | novel | c.674N>C | p.Val225Ala | p.V225A | Q96FJ0 | protein_coding | tolerated(0.6) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
STAMBPL1 | SNV | Missense_Mutation | c.143N>A | p.Pro48Gln | p.P48Q | Q96FJ0 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
STAMBPL1 | insertion | Frame_Shift_Ins | rs752994755 | c.1206_1207insA | p.Phe407LeufsTer55 | p.F407Lfs*55 | Q96FJ0 | protein_coding | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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