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Gene: SPECC1L |
Gene summary for SPECC1L |
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Gene information | Species | Human | Gene symbol | SPECC1L | Gene ID | 23384 |
Gene name | sperm antigen with calponin homology and coiled-coil domains 1 like | |
Gene Alias | CYTSA | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | B2RMV2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23384 | SPECC1L | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.20e-04 | 1.72e-01 | 0.0155 |
23384 | SPECC1L | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.06e-20 | 7.04e-01 | -0.1808 |
23384 | SPECC1L | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.12e-13 | 4.92e-01 | -0.0811 |
23384 | SPECC1L | HTA11_78_2000001011 | Human | Colorectum | AD | 1.26e-15 | 5.50e-01 | -0.1088 |
23384 | SPECC1L | HTA11_347_2000001011 | Human | Colorectum | AD | 1.29e-52 | 1.12e+00 | -0.1954 |
23384 | SPECC1L | HTA11_411_2000001011 | Human | Colorectum | SER | 1.97e-12 | 1.02e+00 | -0.2602 |
23384 | SPECC1L | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.44e-16 | 1.20e+00 | -0.2196 |
23384 | SPECC1L | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.15e-08 | 4.40e-01 | -0.1207 |
23384 | SPECC1L | HTA11_83_2000001011 | Human | Colorectum | SER | 5.34e-22 | 7.27e-01 | -0.1526 |
23384 | SPECC1L | HTA11_696_2000001011 | Human | Colorectum | AD | 3.47e-46 | 8.47e-01 | -0.1464 |
23384 | SPECC1L | HTA11_866_2000001011 | Human | Colorectum | AD | 9.67e-31 | 6.83e-01 | -0.1001 |
23384 | SPECC1L | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.54e-24 | 6.46e-01 | -0.059 |
23384 | SPECC1L | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.75e-16 | 9.04e-01 | -0.1706 |
23384 | SPECC1L | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.71e-10 | 6.78e-01 | -0.2061 |
23384 | SPECC1L | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.22e-05 | 6.23e-01 | -0.1462 |
23384 | SPECC1L | HTA11_546_2000001011 | Human | Colorectum | AD | 5.67e-10 | 5.48e-01 | -0.0842 |
23384 | SPECC1L | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.84e-07 | 4.14e-01 | -0.0179 |
23384 | SPECC1L | HTA11_866_3004761011 | Human | Colorectum | AD | 4.49e-11 | 3.59e-01 | 0.096 |
23384 | SPECC1L | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.32e-04 | 3.56e-01 | 0.0446 |
23384 | SPECC1L | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.79e-02 | 3.40e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPECC1L | SNV | Missense_Mutation | novel | c.533N>T | p.Arg178Ile | p.R178I | Q69YQ0 | protein_coding | deleterious(0) | benign(0.445) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPECC1L | SNV | Missense_Mutation | novel | c.2425N>C | p.Asn809His | p.N809H | Q69YQ0 | protein_coding | tolerated(0.06) | probably_damaging(0.991) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPECC1L | SNV | Missense_Mutation | novel | c.166N>A | p.Asp56Asn | p.D56N | Q69YQ0 | protein_coding | deleterious(0) | possibly_damaging(0.756) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
SPECC1L | SNV | Missense_Mutation | novel | c.118N>T | p.Leu40Phe | p.L40F | Q69YQ0 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SPECC1L | SNV | Missense_Mutation | c.1990G>T | p.Asp664Tyr | p.D664Y | Q69YQ0 | protein_coding | deleterious(0) | possibly_damaging(0.875) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPECC1L | SNV | Missense_Mutation | novel | c.374N>T | p.Arg125Ile | p.R125I | Q69YQ0 | protein_coding | deleterious(0) | possibly_damaging(0.776) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SPECC1L | SNV | Missense_Mutation | c.2199N>T | p.Lys733Asn | p.K733N | Q69YQ0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
SPECC1L | SNV | Missense_Mutation | c.1708N>A | p.Ala570Thr | p.A570T | Q69YQ0 | protein_coding | deleterious(0.05) | benign(0.279) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPECC1L | SNV | Missense_Mutation | c.1709N>T | p.Ala570Val | p.A570V | Q69YQ0 | protein_coding | deleterious(0.04) | benign(0.35) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPECC1L | SNV | Missense_Mutation | c.350A>C | p.Lys117Thr | p.K117T | Q69YQ0 | protein_coding | deleterious(0) | possibly_damaging(0.724) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23384 | SPECC1L | NA | methotrexate | METHOTREXATE | 18539621 |
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