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Gene: SPATS2 |
Gene summary for SPATS2 |
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Gene information | Species | Human | Gene symbol | SPATS2 | Gene ID | 65244 |
Gene name | spermatogenesis associated serine rich 2 | |
Gene Alias | Nbla00526 | |
Cytomap | 12q13.12 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R101 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65244 | SPATS2 | CA_HPV_3 | Human | Cervix | CC | 1.51e-12 | 3.63e-01 | 0.0414 |
65244 | SPATS2 | CCI_1 | Human | Cervix | CC | 1.49e-04 | 6.63e-01 | 0.528 |
65244 | SPATS2 | CCI_2 | Human | Cervix | CC | 9.89e-03 | 5.74e-01 | 0.5249 |
65244 | SPATS2 | CCI_3 | Human | Cervix | CC | 1.57e-14 | 1.00e+00 | 0.516 |
65244 | SPATS2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.48e-03 | 8.34e-01 | 0.3487 |
65244 | SPATS2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.16e-07 | -2.96e-01 | 0.3005 |
65244 | SPATS2 | A001-C-207 | Human | Colorectum | FAP | 1.39e-04 | -2.79e-01 | 0.1278 |
65244 | SPATS2 | A015-C-203 | Human | Colorectum | FAP | 7.81e-27 | -3.68e-01 | -0.1294 |
65244 | SPATS2 | A015-C-204 | Human | Colorectum | FAP | 1.12e-05 | -1.89e-01 | -0.0228 |
65244 | SPATS2 | A014-C-040 | Human | Colorectum | FAP | 1.75e-04 | -4.09e-01 | -0.1184 |
65244 | SPATS2 | A002-C-201 | Human | Colorectum | FAP | 7.33e-10 | -2.02e-01 | 0.0324 |
65244 | SPATS2 | A002-C-203 | Human | Colorectum | FAP | 7.55e-05 | -1.56e-01 | 0.2786 |
65244 | SPATS2 | A001-C-119 | Human | Colorectum | FAP | 2.54e-04 | 2.68e-02 | -0.1557 |
65244 | SPATS2 | A001-C-108 | Human | Colorectum | FAP | 7.24e-17 | -2.12e-01 | -0.0272 |
65244 | SPATS2 | A002-C-205 | Human | Colorectum | FAP | 2.04e-17 | -2.04e-01 | -0.1236 |
65244 | SPATS2 | A001-C-104 | Human | Colorectum | FAP | 3.66e-04 | -2.36e-01 | 0.0184 |
65244 | SPATS2 | A015-C-005 | Human | Colorectum | FAP | 7.82e-03 | -2.04e-01 | -0.0336 |
65244 | SPATS2 | A015-C-006 | Human | Colorectum | FAP | 1.32e-13 | -2.00e-01 | -0.0994 |
65244 | SPATS2 | A015-C-106 | Human | Colorectum | FAP | 5.33e-13 | -3.11e-01 | -0.0511 |
65244 | SPATS2 | A002-C-114 | Human | Colorectum | FAP | 6.65e-15 | -3.30e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATS2 | SNV | Missense_Mutation | novel | c.544N>A | p.Gly182Ser | p.G182S | Q86XZ4 | protein_coding | tolerated(0.22) | possibly_damaging(0.613) | TCGA-85-8071-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPATS2 | SNV | Missense_Mutation | novel | c.24N>T | p.Lys8Asn | p.K8N | Q86XZ4 | protein_coding | deleterious(0.02) | possibly_damaging(0.521) | TCGA-94-8490-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SPATS2 | insertion | Nonsense_Mutation | novel | c.1614_1615insTGAAAGAGGC | p.Gln539Ter | p.Q539* | Q86XZ4 | protein_coding | TCGA-98-7454-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
SPATS2 | SNV | Missense_Mutation | novel | c.487N>T | p.Asp163Tyr | p.D163Y | Q86XZ4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-X4-A8KQ-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | eligard | SD |
SPATS2 | SNV | Missense_Mutation | c.851N>T | p.Arg284Leu | p.R284L | Q86XZ4 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPATS2 | SNV | Missense_Mutation | c.1192N>A | p.Ala398Thr | p.A398T | Q86XZ4 | protein_coding | tolerated(0.77) | benign(0) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPATS2 | SNV | Missense_Mutation | rs375147036 | c.118N>T | p.Arg40Cys | p.R40C | Q86XZ4 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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