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Gene: SPATA17 |
Gene summary for SPATA17 |
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Gene information | Species | Human | Gene symbol | SPATA17 | Gene ID | 128153 |
Gene name | spermatogenesis associated 17 | |
Gene Alias | CFAP305 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96L03 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
128153 | SPATA17 | RNA-P17T-P17T-6 | Human | Lung | IAC | 4.71e-02 | 4.64e-01 | 0.3385 |
128153 | SPATA17 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.00e-03 | 5.60e-01 | -0.0238 |
128153 | SPATA17 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.47e-02 | 5.23e-01 | -0.0296 |
128153 | SPATA17 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.24e-04 | 5.19e-01 | -0.0263 |
128153 | SPATA17 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.06e-02 | 1.75e-01 | -0.0132 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATA17 | SNV | Missense_Mutation | novel | c.1073N>C | p.Gly358Ala | p.G358A | Q96L03 | protein_coding | tolerated(0.06) | benign(0.382) | TCGA-55-8096-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SPATA17 | SNV | Missense_Mutation | c.743N>G | p.Thr248Ser | p.T248S | Q96L03 | protein_coding | tolerated(0.35) | benign(0) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SPATA17 | SNV | Missense_Mutation | c.611N>A | p.Pro204His | p.P204H | Q96L03 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-78-7162-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SPATA17 | SNV | Missense_Mutation | c.848G>T | p.Trp283Leu | p.W283L | Q96L03 | protein_coding | tolerated(0.06) | benign(0.066) | TCGA-78-7542-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SPATA17 | SNV | Missense_Mutation | c.628N>C | p.Asp210His | p.D210H | Q96L03 | protein_coding | tolerated(0.56) | benign(0) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SPATA17 | SNV | Missense_Mutation | novel | c.131N>A | p.Arg44Gln | p.R44Q | Q96L03 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-97-8172-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPATA17 | SNV | Missense_Mutation | novel | c.993G>T | p.Trp331Cys | p.W331C | Q96L03 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SPATA17 | SNV | Missense_Mutation | novel | c.353N>T | p.Lys118Ile | p.K118I | Q96L03 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-56-8305-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SPATA17 | SNV | Missense_Mutation | rs368705475 | c.788N>A | p.Arg263Gln | p.R263Q | Q96L03 | protein_coding | deleterious(0.03) | probably_damaging(0.96) | TCGA-60-2703-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SPATA17 | SNV | Missense_Mutation | c.444N>T | p.Lys148Asn | p.K148N | Q96L03 | protein_coding | deleterious(0.01) | possibly_damaging(0.844) | TCGA-66-2756-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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