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Gene: SPAM1 |
Gene summary for SPAM1 |
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Gene information | Species | Human | Gene symbol | SPAM1 | Gene ID | 6677 |
Gene name | sperm adhesion molecule 1 | |
Gene Alias | HEL-S-96n | |
Cytomap | 7q31.32 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P38567 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6677 | SPAM1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 1.93e-01 | 0.0216 |
6677 | SPAM1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.59e-07 | 2.54e-01 | -0.0811 |
6677 | SPAM1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.08e-06 | 3.67e-01 | -0.2196 |
6677 | SPAM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.91e-05 | 1.80e-01 | -0.1207 |
6677 | SPAM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.75e-18 | 3.51e-01 | -0.1464 |
6677 | SPAM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.36e-06 | 1.40e-01 | -0.1001 |
6677 | SPAM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.60e-11 | 2.68e-01 | -0.059 |
6677 | SPAM1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 1.89e-01 | -0.1706 |
6677 | SPAM1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.16e-07 | 3.01e-01 | -0.2061 |
6677 | SPAM1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.15e-01 | -0.1462 |
6677 | SPAM1 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.78e-03 | 1.84e-01 | -0.0842 |
6677 | SPAM1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.15e-02 | 1.58e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007009 | Colorectum | SER | plasma membrane organization | 36/2897 | 142/18723 | 1.50e-03 | 1.62e-02 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPAM1 | SNV | Missense_Mutation | novel | c.1042N>G | p.Met348Val | p.M348V | P38567 | protein_coding | tolerated(0.41) | benign(0.013) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SPAM1 | SNV | Missense_Mutation | c.351G>T | p.Lys117Asn | p.K117N | P38567 | protein_coding | tolerated(0.17) | benign(0.013) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPAM1 | SNV | Missense_Mutation | rs781017782 | c.979N>A | p.Glu327Lys | p.E327K | P38567 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-E6-A1M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SPAM1 | SNV | Missense_Mutation | novel | c.142N>T | p.Pro48Ser | p.P48S | P38567 | protein_coding | tolerated(0.21) | possibly_damaging(0.462) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPAM1 | SNV | Missense_Mutation | novel | c.1142N>A | p.Cys381Tyr | p.C381Y | P38567 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SPAM1 | SNV | Missense_Mutation | rs200074039 | c.1105G>A | p.Val369Ile | p.V369I | P38567 | protein_coding | tolerated(0.14) | possibly_damaging(0.518) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPAM1 | insertion | Frame_Shift_Ins | novel | c.1291_1292insA | p.Phe433IlefsTer7 | p.F433Ifs*7 | P38567 | protein_coding | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SPAM1 | insertion | Frame_Shift_Ins | novel | c.1438_1439insGGACAAG | p.Ile480ArgfsTer29 | p.I480Rfs*29 | P38567 | protein_coding | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SPAM1 | insertion | Frame_Shift_Ins | novel | c.1396_1397insTCTCC | p.Asp466ValfsTer6 | p.D466Vfs*6 | P38567 | protein_coding | TCGA-B5-A11F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD | ||
SPAM1 | insertion | Nonsense_Mutation | novel | c.180_181insTGCTGAACCAATTCAATAGAC | p.Cys60_Leu61insCysTerThrAsnSerIleAsp | p.C60_L61insC*TNSID | P38567 | protein_coding | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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