GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498113 | Thyroid | PTC | proteasomal protein catabolic process | 297/5968 | 490/18723 | 4.58e-40 | 9.63e-37 | 297 |
GO:0043161113 | Thyroid | PTC | proteasome-mediated ubiquitin-dependent protein catabolic process | 254/5968 | 412/18723 | 3.91e-36 | 4.54e-33 | 254 |
GO:0009896113 | Thyroid | PTC | positive regulation of catabolic process | 278/5968 | 492/18723 | 3.35e-30 | 2.64e-27 | 278 |
GO:0031331113 | Thyroid | PTC | positive regulation of cellular catabolic process | 249/5968 | 427/18723 | 5.28e-30 | 3.58e-27 | 249 |
GO:0042176113 | Thyroid | PTC | regulation of protein catabolic process | 231/5968 | 391/18723 | 4.76e-29 | 2.14e-26 | 231 |
GO:1903362113 | Thyroid | PTC | regulation of cellular protein catabolic process | 162/5968 | 255/18723 | 1.62e-25 | 5.12e-23 | 162 |
GO:1903050113 | Thyroid | PTC | regulation of proteolysis involved in cellular protein catabolic process | 140/5968 | 221/18723 | 4.63e-22 | 1.01e-19 | 140 |
GO:0045732113 | Thyroid | PTC | positive regulation of protein catabolic process | 142/5968 | 231/18723 | 1.43e-20 | 2.38e-18 | 142 |
GO:2000058113 | Thyroid | PTC | regulation of ubiquitin-dependent protein catabolic process | 110/5968 | 164/18723 | 1.83e-20 | 2.97e-18 | 110 |
GO:0061136113 | Thyroid | PTC | regulation of proteasomal protein catabolic process | 121/5968 | 187/18723 | 2.25e-20 | 3.37e-18 | 121 |
GO:0032434113 | Thyroid | PTC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 94/5968 | 134/18723 | 9.17e-20 | 1.23e-17 | 94 |
GO:1903364113 | Thyroid | PTC | positive regulation of cellular protein catabolic process | 104/5968 | 155/18723 | 1.93e-19 | 2.39e-17 | 104 |
GO:0045862113 | Thyroid | PTC | positive regulation of proteolysis | 198/5968 | 372/18723 | 6.68e-18 | 6.91e-16 | 198 |
GO:1901800112 | Thyroid | PTC | positive regulation of proteasomal protein catabolic process | 80/5968 | 114/18723 | 4.80e-17 | 4.27e-15 | 80 |
GO:1903052112 | Thyroid | PTC | positive regulation of proteolysis involved in cellular protein catabolic process | 88/5968 | 133/18723 | 4.30e-16 | 3.39e-14 | 88 |
GO:0032436113 | Thyroid | PTC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 66/5968 | 90/18723 | 7.51e-16 | 5.64e-14 | 66 |
GO:0010563113 | Thyroid | PTC | negative regulation of phosphorus metabolic process | 219/5968 | 442/18723 | 4.47e-15 | 3.07e-13 | 219 |
GO:0045936113 | Thyroid | PTC | negative regulation of phosphate metabolic process | 218/5968 | 441/18723 | 7.08e-15 | 4.75e-13 | 218 |
GO:2000060113 | Thyroid | PTC | positive regulation of ubiquitin-dependent protein catabolic process | 73/5968 | 107/18723 | 1.19e-14 | 7.75e-13 | 73 |
GO:0001933113 | Thyroid | PTC | negative regulation of protein phosphorylation | 173/5968 | 342/18723 | 3.46e-13 | 1.75e-11 | 173 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOCS5 | SNV | Missense_Mutation | novel | c.569C>T | p.Pro190Leu | p.P190L | O75159 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
SOCS5 | SNV | Missense_Mutation | novel | c.212C>A | p.Pro71His | p.P71H | O75159 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.996) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOCS5 | SNV | Missense_Mutation | novel | c.492G>A | p.Met164Ile | p.M164I | O75159 | protein_coding | tolerated(0.41) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOCS5 | SNV | Missense_Mutation | rs755197965 | c.215N>T | p.Ser72Leu | p.S72L | O75159 | protein_coding | tolerated_low_confidence(0.38) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SOCS5 | SNV | Missense_Mutation | rs149307689 | c.1391N>T | p.Ser464Leu | p.S464L | O75159 | protein_coding | tolerated(0.14) | benign(0.007) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SOCS5 | insertion | Frame_Shift_Ins | novel | c.752_753insGGGAT | p.Asp251GlufsTer55 | p.D251Efs*55 | O75159 | protein_coding | | | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
SOCS5 | insertion | In_Frame_Ins | novel | c.805_806insAATATTTTCTCTTAA | p.Arg268_Arg269insGlnTyrPheLeuLeu | p.R268_R269insQYFLL | O75159 | protein_coding | | | TCGA-AX-A05W-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOCS5 | insertion | Frame_Shift_Ins | novel | c.328_329insAACA | p.Arg110GlnfsTer31 | p.R110Qfs*31 | O75159 | protein_coding | | | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
SOCS5 | insertion | In_Frame_Ins | novel | c.331_332insCACACGGCCTCATCA | p.Arg110_Arg111insThrHisGlyLeuIle | p.R110_R111insTHGLI | O75159 | protein_coding | | | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
SOCS5 | insertion | Nonsense_Mutation | novel | c.567_568insTCTCTTTGACAGA | p.Pro190SerfsTer3 | p.P190Sfs*3 | O75159 | protein_coding | | | TCGA-D1-A102-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |