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Gene: SNX19 |
Gene summary for SNX19 |
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Gene information | Species | Human | Gene symbol | SNX19 | Gene ID | 399979 |
Gene name | sorting nexin 19 | |
Gene Alias | CHET8 | |
Cytomap | 11q24.3-q25 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | B7ZAU9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
399979 | SNX19 | C04 | Human | Oral cavity | OSCC | 8.34e-15 | 6.01e-01 | 0.2633 |
399979 | SNX19 | C21 | Human | Oral cavity | OSCC | 1.22e-03 | 2.18e-01 | 0.2678 |
399979 | SNX19 | C30 | Human | Oral cavity | OSCC | 1.13e-18 | 7.23e-01 | 0.3055 |
399979 | SNX19 | C51 | Human | Oral cavity | OSCC | 6.39e-03 | 2.01e-01 | 0.2674 |
399979 | SNX19 | SYSMH1 | Human | Oral cavity | OSCC | 1.71e-07 | 2.08e-01 | 0.1127 |
399979 | SNX19 | SYSMH2 | Human | Oral cavity | OSCC | 1.39e-03 | 1.90e-01 | 0.2326 |
399979 | SNX19 | SYSMH3 | Human | Oral cavity | OSCC | 1.30e-07 | 2.21e-01 | 0.2442 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160508 | Oral cavity | OSCC | vesicle organization | 189/7305 | 300/18723 | 2.40e-17 | 2.14e-15 | 189 |
GO:000930610 | Oral cavity | OSCC | protein secretion | 169/7305 | 359/18723 | 1.04e-03 | 5.34e-03 | 169 |
GO:003559210 | Oral cavity | OSCC | establishment of protein localization to extracellular region | 169/7305 | 360/18723 | 1.21e-03 | 6.08e-03 | 169 |
GO:00716929 | Oral cavity | OSCC | protein localization to extracellular region | 172/7305 | 368/18723 | 1.40e-03 | 6.79e-03 | 172 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX19 | SNV | Missense_Mutation | c.2774T>G | p.Ile925Ser | p.I925S | Q92543 | protein_coding | deleterious(0) | possibly_damaging(0.815) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
SNX19 | SNV | Missense_Mutation | novel | c.2216N>T | p.Thr739Ile | p.T739I | Q92543 | protein_coding | deleterious(0.01) | benign(0.11) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SNX19 | SNV | Missense_Mutation | novel | c.2780N>T | p.Gly927Val | p.G927V | Q92543 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SNX19 | SNV | Missense_Mutation | novel | c.1821N>T | p.Lys607Asn | p.K607N | Q92543 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SNX19 | SNV | Missense_Mutation | rs748174880 | c.1565N>T | p.Ser522Ile | p.S522I | Q92543 | protein_coding | deleterious(0.03) | benign(0.039) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SNX19 | SNV | Missense_Mutation | novel | c.1052N>G | p.Asn351Ser | p.N351S | Q92543 | protein_coding | tolerated(0.79) | benign(0.003) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNX19 | SNV | Missense_Mutation | novel | c.352N>C | p.Tyr118His | p.Y118H | Q92543 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNX19 | SNV | Missense_Mutation | c.2072N>T | p.Ala691Val | p.A691V | Q92543 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNX19 | SNV | Missense_Mutation | c.420G>T | p.Gln140His | p.Q140H | Q92543 | protein_coding | tolerated(0.22) | possibly_damaging(0.676) | TCGA-BG-A0VZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
SNX19 | SNV | Missense_Mutation | novel | c.2540N>G | p.Phe847Cys | p.F847C | Q92543 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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