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Gene: SNX1 |
Gene summary for SNX1 |
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Gene information | Species | Human | Gene symbol | SNX1 | Gene ID | 6642 |
Gene name | sorting nexin 1 | |
Gene Alias | HsT17379 | |
Cytomap | 15q22.31 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q13596 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6642 | SNX1 | LZE2T | Human | Esophagus | ESCC | 4.47e-02 | 4.23e-01 | 0.082 |
6642 | SNX1 | LZE4T | Human | Esophagus | ESCC | 8.41e-14 | 4.15e-01 | 0.0811 |
6642 | SNX1 | LZE7T | Human | Esophagus | ESCC | 3.76e-09 | 6.14e-01 | 0.0667 |
6642 | SNX1 | LZE8T | Human | Esophagus | ESCC | 5.92e-09 | 2.21e-01 | 0.067 |
6642 | SNX1 | LZE20T | Human | Esophagus | ESCC | 3.91e-05 | 1.67e-01 | 0.0662 |
6642 | SNX1 | LZE24T | Human | Esophagus | ESCC | 4.38e-22 | 3.92e-01 | 0.0596 |
6642 | SNX1 | LZE21T | Human | Esophagus | ESCC | 1.90e-05 | 2.02e-01 | 0.0655 |
6642 | SNX1 | LZE6T | Human | Esophagus | ESCC | 9.07e-05 | 2.80e-01 | 0.0845 |
6642 | SNX1 | P1T-E | Human | Esophagus | ESCC | 1.25e-08 | 6.16e-01 | 0.0875 |
6642 | SNX1 | P2T-E | Human | Esophagus | ESCC | 5.33e-31 | 7.67e-01 | 0.1177 |
6642 | SNX1 | P4T-E | Human | Esophagus | ESCC | 2.54e-29 | 8.41e-01 | 0.1323 |
6642 | SNX1 | P5T-E | Human | Esophagus | ESCC | 5.68e-20 | 3.36e-01 | 0.1327 |
6642 | SNX1 | P8T-E | Human | Esophagus | ESCC | 3.60e-40 | 8.54e-01 | 0.0889 |
6642 | SNX1 | P9T-E | Human | Esophagus | ESCC | 7.52e-12 | 3.67e-01 | 0.1131 |
6642 | SNX1 | P10T-E | Human | Esophagus | ESCC | 6.44e-35 | 6.55e-01 | 0.116 |
6642 | SNX1 | P11T-E | Human | Esophagus | ESCC | 6.28e-10 | 6.03e-01 | 0.1426 |
6642 | SNX1 | P12T-E | Human | Esophagus | ESCC | 9.19e-40 | 8.10e-01 | 0.1122 |
6642 | SNX1 | P15T-E | Human | Esophagus | ESCC | 5.68e-52 | 1.11e+00 | 0.1149 |
6642 | SNX1 | P16T-E | Human | Esophagus | ESCC | 1.09e-74 | 2.24e+00 | 0.1153 |
6642 | SNX1 | P17T-E | Human | Esophagus | ESCC | 9.76e-07 | 4.25e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0042177 | Colorectum | AD | negative regulation of protein catabolic process | 55/3918 | 121/18723 | 1.19e-09 | 8.85e-08 | 55 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:1901361 | Colorectum | AD | organic cyclic compound catabolic process | 153/3918 | 495/18723 | 8.23e-08 | 4.18e-06 | 153 |
GO:0032386 | Colorectum | AD | regulation of intracellular transport | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0042147 | Colorectum | AD | retrograde transport, endosome to Golgi | 37/3918 | 91/18723 | 1.46e-05 | 3.14e-04 | 37 |
GO:0045861 | Colorectum | AD | negative regulation of proteolysis | 106/3918 | 351/18723 | 2.33e-05 | 4.57e-04 | 106 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0016042 | Colorectum | AD | lipid catabolic process | 97/3918 | 320/18723 | 4.31e-05 | 7.56e-04 | 97 |
GO:0006898 | Colorectum | AD | receptor-mediated endocytosis | 76/3918 | 244/18723 | 1.07e-04 | 1.59e-03 | 76 |
GO:0030100 | Colorectum | AD | regulation of endocytosis | 67/3918 | 211/18723 | 1.42e-04 | 2.01e-03 | 67 |
GO:0032456 | Colorectum | AD | endocytic recycling | 28/3918 | 73/18723 | 4.87e-04 | 5.30e-03 | 28 |
GO:0098927 | Colorectum | AD | vesicle-mediated transport between endosomal compartments | 19/3918 | 43/18723 | 5.03e-04 | 5.43e-03 | 19 |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414425 | Prostate | BPH | Endocytosis | 89/1718 | 251/8465 | 1.06e-08 | 1.29e-07 | 7.99e-08 | 89 |
hsa04144111 | Prostate | BPH | Endocytosis | 89/1718 | 251/8465 | 1.06e-08 | 1.29e-07 | 7.99e-08 | 89 |
hsa0414426 | Prostate | Tumor | Endocytosis | 92/1791 | 251/8465 | 7.83e-09 | 1.04e-07 | 6.43e-08 | 92 |
hsa0414435 | Prostate | Tumor | Endocytosis | 92/1791 | 251/8465 | 7.83e-09 | 1.04e-07 | 6.43e-08 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX1 | SNV | Missense_Mutation | novel | c.371N>A | p.Ser124Tyr | p.S124Y | Q13596 | protein_coding | tolerated(0.14) | possibly_damaging(0.681) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNX1 | SNV | Missense_Mutation | novel | c.1067G>T | p.Ser356Ile | p.S356I | Q13596 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-QS-A8F1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
SNX1 | SNV | Missense_Mutation | rs200079069 | c.386C>A | p.Pro129Gln | p.P129Q | Q13596 | protein_coding | tolerated(0.22) | benign(0.003) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SNX1 | SNV | Missense_Mutation | novel | c.1283N>T | p.Gln428Leu | p.Q428L | Q13596 | protein_coding | tolerated(0.09) | probably_damaging(0.979) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNX1 | SNV | Missense_Mutation | c.1037N>T | p.Gln346Leu | p.Q346L | Q13596 | protein_coding | tolerated(0.37) | benign(0.007) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SNX1 | SNV | Missense_Mutation | c.607C>G | p.Gln203Glu | p.Q203E | Q13596 | protein_coding | tolerated(0.24) | benign(0.297) | TCGA-37-3789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SNX1 | SNV | Missense_Mutation | rs146206725 | c.970C>T | p.Arg324Trp | p.R324W | Q13596 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-85-8479-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SNX1 | SNV | Missense_Mutation | novel | c.569N>C | p.Phe190Ser | p.F190S | Q13596 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SNX1 | SNV | Missense_Mutation | novel | c.1373C>G | p.Ser458Cys | p.S458C | Q13596 | protein_coding | deleterious(0.01) | probably_damaging(0.944) | TCGA-NC-A5HH-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SNX1 | SNV | Missense_Mutation | c.635N>T | p.Pro212Leu | p.P212L | Q13596 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-J9-A52C-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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