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Gene: SLC9A9 |
Gene summary for SLC9A9 |
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Gene information | Species | Human | Gene symbol | SLC9A9 | Gene ID | 285195 |
Gene name | solute carrier family 9 member A9 | |
Gene Alias | AUTS16 | |
Cytomap | 3q24 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8IVB4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
285195 | SLC9A9 | LZE4T | Human | Esophagus | ESCC | 7.59e-15 | 4.95e-01 | 0.0811 |
285195 | SLC9A9 | P2T-E | Human | Esophagus | ESCC | 3.22e-06 | 2.55e-02 | 0.1177 |
285195 | SLC9A9 | P4T-E | Human | Esophagus | ESCC | 1.07e-07 | 2.71e-01 | 0.1323 |
285195 | SLC9A9 | P8T-E | Human | Esophagus | ESCC | 4.23e-13 | 7.72e-02 | 0.0889 |
285195 | SLC9A9 | P9T-E | Human | Esophagus | ESCC | 1.86e-13 | 3.33e-01 | 0.1131 |
285195 | SLC9A9 | P10T-E | Human | Esophagus | ESCC | 1.31e-23 | 3.68e-01 | 0.116 |
285195 | SLC9A9 | P11T-E | Human | Esophagus | ESCC | 2.13e-02 | 9.54e-02 | 0.1426 |
285195 | SLC9A9 | P12T-E | Human | Esophagus | ESCC | 1.23e-15 | 4.47e-01 | 0.1122 |
285195 | SLC9A9 | P15T-E | Human | Esophagus | ESCC | 6.37e-12 | 3.30e-01 | 0.1149 |
285195 | SLC9A9 | P22T-E | Human | Esophagus | ESCC | 6.05e-16 | 3.31e-01 | 0.1236 |
285195 | SLC9A9 | P23T-E | Human | Esophagus | ESCC | 6.56e-04 | 1.34e-01 | 0.108 |
285195 | SLC9A9 | P26T-E | Human | Esophagus | ESCC | 6.37e-25 | 4.40e-01 | 0.1276 |
285195 | SLC9A9 | P27T-E | Human | Esophagus | ESCC | 1.95e-16 | 3.77e-01 | 0.1055 |
285195 | SLC9A9 | P28T-E | Human | Esophagus | ESCC | 2.21e-19 | 5.02e-01 | 0.1149 |
285195 | SLC9A9 | P30T-E | Human | Esophagus | ESCC | 8.82e-27 | 1.19e+00 | 0.137 |
285195 | SLC9A9 | P32T-E | Human | Esophagus | ESCC | 8.71e-08 | 5.58e-02 | 0.1666 |
285195 | SLC9A9 | P42T-E | Human | Esophagus | ESCC | 2.55e-08 | 2.76e-01 | 0.1175 |
285195 | SLC9A9 | P47T-E | Human | Esophagus | ESCC | 7.60e-08 | 6.87e-02 | 0.1067 |
285195 | SLC9A9 | P48T-E | Human | Esophagus | ESCC | 7.40e-05 | 1.19e-01 | 0.0959 |
285195 | SLC9A9 | P52T-E | Human | Esophagus | ESCC | 2.83e-20 | 2.99e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190260018 | Esophagus | ESCC | proton transmembrane transport | 88/8552 | 157/18723 | 5.62e-03 | 2.10e-02 | 88 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC9A9 | SNV | Missense_Mutation | rs768229420 | c.1405G>A | p.Val469Met | p.V469M | Q8IVB4 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLC9A9 | SNV | Missense_Mutation | novel | c.1192C>A | p.Leu398Ile | p.L398I | Q8IVB4 | protein_coding | tolerated(1) | benign(0.023) | TCGA-AX-A2IN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLC9A9 | SNV | Missense_Mutation | c.1364C>A | p.Ser455Tyr | p.S455Y | Q8IVB4 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC9A9 | SNV | Missense_Mutation | novel | c.1805C>T | p.Pro602Leu | p.P602L | Q8IVB4 | protein_coding | tolerated(0.31) | benign(0.007) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
SLC9A9 | SNV | Missense_Mutation | novel | c.167T>C | p.Met56Thr | p.M56T | Q8IVB4 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC9A9 | SNV | Missense_Mutation | novel | c.770A>C | p.Tyr257Ser | p.Y257S | Q8IVB4 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BK-A6W3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC9A9 | SNV | Missense_Mutation | c.169G>C | p.Val57Leu | p.V57L | Q8IVB4 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-BS-A0U8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
SLC9A9 | SNV | Missense_Mutation | c.1697N>A | p.Pro566His | p.P566H | Q8IVB4 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC9A9 | SNV | Missense_Mutation | c.758N>T | p.Ser253Phe | p.S253F | Q8IVB4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC9A9 | SNV | Missense_Mutation | c.1364N>A | p.Ser455Tyr | p.S455Y | Q8IVB4 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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