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Gene: SLC38A6 |
Gene summary for SLC38A6 |
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Gene information | Species | Human | Gene symbol | SLC38A6 | Gene ID | 145389 |
Gene name | solute carrier family 38 member 6 | |
Gene Alias | NAT-1 | |
Cytomap | 14q23.1 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | Q8IZM9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
145389 | SLC38A6 | LZE4T | Human | Esophagus | ESCC | 9.61e-11 | 3.45e-01 | 0.0811 |
145389 | SLC38A6 | LZE5T | Human | Esophagus | ESCC | 1.63e-02 | 2.34e-01 | 0.0514 |
145389 | SLC38A6 | LZE8T | Human | Esophagus | ESCC | 4.53e-02 | 1.15e-01 | 0.067 |
145389 | SLC38A6 | LZE20T | Human | Esophagus | ESCC | 3.76e-02 | 1.47e-01 | 0.0662 |
145389 | SLC38A6 | LZE22T | Human | Esophagus | ESCC | 5.99e-04 | 3.71e-01 | 0.068 |
145389 | SLC38A6 | LZE24T | Human | Esophagus | ESCC | 7.01e-28 | 6.76e-01 | 0.0596 |
145389 | SLC38A6 | P2T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.20e-01 | 0.1177 |
145389 | SLC38A6 | P4T-E | Human | Esophagus | ESCC | 8.04e-15 | 1.72e-01 | 0.1323 |
145389 | SLC38A6 | P5T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.13e-01 | 0.1327 |
145389 | SLC38A6 | P8T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.31e-01 | 0.0889 |
145389 | SLC38A6 | P9T-E | Human | Esophagus | ESCC | 9.13e-10 | 1.84e-01 | 0.1131 |
145389 | SLC38A6 | P10T-E | Human | Esophagus | ESCC | 2.28e-35 | 5.26e-01 | 0.116 |
145389 | SLC38A6 | P11T-E | Human | Esophagus | ESCC | 6.32e-07 | 2.48e-01 | 0.1426 |
145389 | SLC38A6 | P12T-E | Human | Esophagus | ESCC | 1.77e-22 | 3.97e-01 | 0.1122 |
145389 | SLC38A6 | P15T-E | Human | Esophagus | ESCC | 3.20e-46 | 8.93e-01 | 0.1149 |
145389 | SLC38A6 | P16T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.79e-01 | 0.1153 |
145389 | SLC38A6 | P20T-E | Human | Esophagus | ESCC | 3.65e-17 | 2.56e-01 | 0.1124 |
145389 | SLC38A6 | P21T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.94e-01 | 0.1617 |
145389 | SLC38A6 | P22T-E | Human | Esophagus | ESCC | 5.00e-17 | 2.81e-01 | 0.1236 |
145389 | SLC38A6 | P23T-E | Human | Esophagus | ESCC | 4.77e-06 | 1.61e-01 | 0.108 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC38A6 | SNV | Missense_Mutation | novel | c.1186N>T | p.Gly396Cys | p.G396C | Q8IZM9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-63-A5MG-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC38A6 | SNV | Missense_Mutation | novel | c.742N>C | p.Glu248Gln | p.E248Q | Q8IZM9 | protein_coding | tolerated(1) | benign(0.027) | TCGA-CR-7394-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC38A6 | SNV | Missense_Mutation | c.1093N>C | p.Phe365Leu | p.F365L | Q8IZM9 | protein_coding | deleterious(0.01) | benign(0.426) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
SLC38A6 | SNV | Missense_Mutation | c.274N>C | p.Ser92Pro | p.S92P | Q8IZM9 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC38A6 | SNV | Missense_Mutation | novel | c.224N>G | p.Val75Gly | p.V75G | Q8IZM9 | protein_coding | deleterious(0) | possibly_damaging(0.854) | TCGA-CG-4437-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC38A6 | SNV | Missense_Mutation | rs762517433 | c.883N>G | p.Ile295Val | p.I295V | Q8IZM9 | protein_coding | tolerated(0.07) | benign(0.01) | TCGA-FP-7829-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
SLC38A6 | SNV | Missense_Mutation | novel | c.745N>G | p.Ser249Gly | p.S249G | Q8IZM9 | protein_coding | deleterious(0.02) | benign(0.056) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
SLC38A6 | deletion | Frame_Shift_Del | c.634delN | p.Lys213AsnfsTer8 | p.K213Nfs*8 | Q8IZM9 | protein_coding | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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