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Gene: SLC35A2 |
Gene summary for SLC35A2 |
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Gene information | Species | Human | Gene symbol | SLC35A2 | Gene ID | 7355 |
Gene name | solute carrier family 35 member A2 | |
Gene Alias | CDG2M | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | P78381 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7355 | SLC35A2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.25e-05 | 2.49e-01 | -0.0811 |
7355 | SLC35A2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.34e-03 | 1.56e-01 | -0.1088 |
7355 | SLC35A2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.49e-08 | 3.01e-01 | -0.1954 |
7355 | SLC35A2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.84e-02 | 1.49e-01 | -0.1526 |
7355 | SLC35A2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.95e-07 | 2.85e-01 | -0.1464 |
7355 | SLC35A2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.73e-06 | 3.33e-01 | -0.059 |
7355 | SLC35A2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.84e-04 | 3.15e-01 | -0.2061 |
7355 | SLC35A2 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.75e-03 | 1.78e-01 | 0.096 |
7355 | SLC35A2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 6.68e-06 | 5.20e-01 | 0.0171 |
7355 | SLC35A2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.22e-05 | 1.84e-01 | 0.0338 |
7355 | SLC35A2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.16e-05 | 2.03e-01 | 0.0674 |
7355 | SLC35A2 | HTA11_7469_2000001011 | Human | Colorectum | AD | 6.84e-04 | 5.39e-01 | -0.0124 |
7355 | SLC35A2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.20e-09 | 2.91e-01 | 0.294 |
7355 | SLC35A2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.96e-07 | 3.71e-01 | 0.281 |
7355 | SLC35A2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.35e-09 | 3.83e-01 | 0.3859 |
7355 | SLC35A2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.90e-08 | 2.87e-01 | 0.3005 |
7355 | SLC35A2 | LZE4T | Human | Esophagus | ESCC | 6.21e-06 | 1.83e-01 | 0.0811 |
7355 | SLC35A2 | LZE7T | Human | Esophagus | ESCC | 1.16e-07 | 2.59e-01 | 0.0667 |
7355 | SLC35A2 | LZE20T | Human | Esophagus | ESCC | 8.42e-07 | 2.22e-01 | 0.0662 |
7355 | SLC35A2 | LZE24T | Human | Esophagus | ESCC | 2.94e-10 | 2.64e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0019318 | Colorectum | AD | hexose metabolic process | 77/3918 | 237/18723 | 1.96e-05 | 4.01e-04 | 77 |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:0005996 | Colorectum | AD | monosaccharide metabolic process | 80/3918 | 257/18723 | 7.31e-05 | 1.17e-03 | 80 |
GO:0006012 | Colorectum | AD | galactose metabolic process | 6/3918 | 10/18723 | 8.03e-03 | 4.73e-02 | 6 |
GO:00159311 | Colorectum | SER | nucleobase-containing compound transport | 54/2897 | 222/18723 | 3.65e-04 | 5.67e-03 | 54 |
GO:00193181 | Colorectum | SER | hexose metabolic process | 56/2897 | 237/18723 | 6.19e-04 | 8.42e-03 | 56 |
GO:00059961 | Colorectum | SER | monosaccharide metabolic process | 59/2897 | 257/18723 | 9.65e-04 | 1.15e-02 | 59 |
GO:00159312 | Colorectum | MSS | nucleobase-containing compound transport | 70/3467 | 222/18723 | 1.92e-06 | 6.01e-05 | 70 |
GO:00193182 | Colorectum | MSS | hexose metabolic process | 63/3467 | 237/18723 | 1.32e-03 | 1.25e-02 | 63 |
GO:00059962 | Colorectum | MSS | monosaccharide metabolic process | 66/3467 | 257/18723 | 2.61e-03 | 2.06e-02 | 66 |
GO:00060121 | Colorectum | MSS | galactose metabolic process | 6/3467 | 10/18723 | 4.25e-03 | 3.04e-02 | 6 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:00059969 | Esophagus | ESCC | monosaccharide metabolic process | 159/8552 | 257/18723 | 1.11e-07 | 1.81e-06 | 159 |
GO:00193189 | Esophagus | ESCC | hexose metabolic process | 147/8552 | 237/18723 | 2.63e-07 | 3.94e-06 | 147 |
GO:000599612 | Liver | Cirrhotic | monosaccharide metabolic process | 104/4634 | 257/18723 | 1.74e-08 | 6.32e-07 | 104 |
GO:001931812 | Liver | Cirrhotic | hexose metabolic process | 97/4634 | 237/18723 | 2.67e-08 | 9.16e-07 | 97 |
GO:00159316 | Liver | Cirrhotic | nucleobase-containing compound transport | 87/4634 | 222/18723 | 1.25e-06 | 2.52e-05 | 87 |
GO:00060123 | Liver | Cirrhotic | galactose metabolic process | 8/4634 | 10/18723 | 3.84e-04 | 3.19e-03 | 8 |
GO:001593111 | Liver | HCC | nucleobase-containing compound transport | 150/7958 | 222/18723 | 3.17e-14 | 2.03e-12 | 150 |
GO:000599621 | Liver | HCC | monosaccharide metabolic process | 167/7958 | 257/18723 | 2.31e-13 | 1.25e-11 | 167 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC35A2 | SNV | Missense_Mutation | c.640C>G | p.Gln214Glu | p.Q214E | P78381 | protein_coding | tolerated(0.26) | benign(0.211) | TCGA-56-6546-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC35A2 | SNV | Missense_Mutation | novel | c.767N>T | p.Ser256Leu | p.S256L | P78381 | protein_coding | tolerated(0.1) | benign(0.326) | TCGA-85-7710-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35A2 | SNV | Missense_Mutation | novel | c.619G>A | p.Val207Ile | p.V207I | P78381 | protein_coding | tolerated(0.09) | possibly_damaging(0.895) | TCGA-CV-6951-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
SLC35A2 | SNV | Missense_Mutation | c.695N>T | p.Ala232Val | p.A232V | P78381 | protein_coding | tolerated(1) | benign(0.017) | TCGA-BR-8286-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC35A2 | SNV | Missense_Mutation | c.868G>A | p.Gly290Ser | p.G290S | P78381 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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