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Gene: SLC2A9 |
Gene summary for SLC2A9 |
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Gene information | Species | Human | Gene symbol | SLC2A9 | Gene ID | 56606 |
Gene name | solute carrier family 2 member 9 | |
Gene Alias | GLUT9 | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q9NRM0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56606 | SLC2A9 | P2T-E | Human | Esophagus | ESCC | 3.63e-19 | 4.46e-01 | 0.1177 |
56606 | SLC2A9 | P4T-E | Human | Esophagus | ESCC | 3.66e-06 | 1.90e-01 | 0.1323 |
56606 | SLC2A9 | P5T-E | Human | Esophagus | ESCC | 3.61e-03 | 7.82e-02 | 0.1327 |
56606 | SLC2A9 | P8T-E | Human | Esophagus | ESCC | 1.39e-07 | 2.12e-01 | 0.0889 |
56606 | SLC2A9 | P9T-E | Human | Esophagus | ESCC | 1.77e-03 | 7.62e-02 | 0.1131 |
56606 | SLC2A9 | P10T-E | Human | Esophagus | ESCC | 5.80e-12 | 1.90e-01 | 0.116 |
56606 | SLC2A9 | P11T-E | Human | Esophagus | ESCC | 6.96e-15 | 5.58e-01 | 0.1426 |
56606 | SLC2A9 | P12T-E | Human | Esophagus | ESCC | 1.40e-07 | 1.70e-01 | 0.1122 |
56606 | SLC2A9 | P15T-E | Human | Esophagus | ESCC | 3.68e-07 | 2.24e-01 | 0.1149 |
56606 | SLC2A9 | P16T-E | Human | Esophagus | ESCC | 2.79e-13 | 1.77e-01 | 0.1153 |
56606 | SLC2A9 | P20T-E | Human | Esophagus | ESCC | 3.76e-06 | 6.93e-02 | 0.1124 |
56606 | SLC2A9 | P21T-E | Human | Esophagus | ESCC | 7.51e-13 | 2.29e-01 | 0.1617 |
56606 | SLC2A9 | P22T-E | Human | Esophagus | ESCC | 1.26e-10 | 1.14e-01 | 0.1236 |
56606 | SLC2A9 | P23T-E | Human | Esophagus | ESCC | 8.56e-03 | 1.32e-01 | 0.108 |
56606 | SLC2A9 | P24T-E | Human | Esophagus | ESCC | 1.69e-05 | 6.38e-02 | 0.1287 |
56606 | SLC2A9 | P26T-E | Human | Esophagus | ESCC | 4.87e-06 | 8.08e-02 | 0.1276 |
56606 | SLC2A9 | P27T-E | Human | Esophagus | ESCC | 1.86e-11 | 2.24e-01 | 0.1055 |
56606 | SLC2A9 | P28T-E | Human | Esophagus | ESCC | 1.49e-10 | 1.17e-01 | 0.1149 |
56606 | SLC2A9 | P30T-E | Human | Esophagus | ESCC | 1.73e-15 | 4.77e-01 | 0.137 |
56606 | SLC2A9 | P36T-E | Human | Esophagus | ESCC | 4.17e-06 | 2.54e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190260018 | Esophagus | ESCC | proton transmembrane transport | 88/8552 | 157/18723 | 5.62e-03 | 2.10e-02 | 88 |
GO:0015749 | Liver | NAFLD | monosaccharide transmembrane transport | 21/1882 | 116/18723 | 5.54e-03 | 4.23e-02 | 21 |
GO:1904659 | Liver | NAFLD | glucose transmembrane transport | 20/1882 | 110/18723 | 6.36e-03 | 4.69e-02 | 20 |
GO:0034219 | Liver | NAFLD | carbohydrate transmembrane transport | 21/1882 | 118/18723 | 6.77e-03 | 4.79e-02 | 21 |
GO:19026007 | Liver | HCC | proton transmembrane transport | 87/7958 | 157/18723 | 7.27e-04 | 4.42e-03 | 87 |
GO:0008643 | Liver | HCC | carbohydrate transport | 80/7958 | 152/18723 | 7.34e-03 | 2.92e-02 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC2A9 | SNV | Missense_Mutation | c.627N>G | p.Ile209Met | p.I209M | Q9NRM0 | protein_coding | deleterious(0) | possibly_damaging(0.718) | TCGA-38-4625-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC2A9 | SNV | Missense_Mutation | c.348A>G | p.Ile116Met | p.I116M | Q9NRM0 | protein_coding | tolerated(0.63) | probably_damaging(0.961) | TCGA-44-6776-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC2A9 | SNV | Missense_Mutation | rs570722567 | c.559N>G | p.Met187Val | p.M187V | Q9NRM0 | protein_coding | deleterious(0.01) | possibly_damaging(0.588) | TCGA-44-7661-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SLC2A9 | SNV | Missense_Mutation | novel | c.1419G>T | p.Gln473His | p.Q473H | Q9NRM0 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-64-5781-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SLC2A9 | SNV | Missense_Mutation | c.650N>T | p.Gln217Leu | p.Q217L | Q9NRM0 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-78-7148-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SLC2A9 | SNV | Missense_Mutation | novel | c.761A>G | p.Asp254Gly | p.D254G | Q9NRM0 | protein_coding | deleterious(0) | benign(0.266) | TCGA-91-8499-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC2A9 | SNV | Missense_Mutation | novel | c.821N>G | p.Gln274Arg | p.Q274R | Q9NRM0 | protein_coding | tolerated(0.61) | benign(0.009) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLC2A9 | SNV | Missense_Mutation | novel | c.46N>A | p.Pro16Thr | p.P16T | Q9NRM0 | protein_coding | tolerated_low_confidence(0.41) | benign(0.01) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLC2A9 | SNV | Missense_Mutation | c.465G>T | p.Met155Ile | p.M155I | Q9NRM0 | protein_coding | deleterious(0) | possibly_damaging(0.877) | TCGA-O1-A52J-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SLC2A9 | SNV | Missense_Mutation | novel | c.536N>T | p.Gly179Val | p.G179V | Q9NRM0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-60-2703-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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