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Gene: SH3RF2 |
Gene summary for SH3RF2 |
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Gene information | Species | Human | Gene symbol | SH3RF2 | Gene ID | 153769 |
Gene name | SH3 domain containing ring finger 2 | |
Gene Alias | HEPP1 | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q08AM8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153769 | SH3RF2 | CCI_2 | Human | Cervix | CC | 2.19e-06 | 7.06e-01 | 0.5249 |
153769 | SH3RF2 | CCI_3 | Human | Cervix | CC | 5.78e-14 | 8.56e-01 | 0.516 |
153769 | SH3RF2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.43e-28 | -6.73e-01 | 0.0155 |
153769 | SH3RF2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.54e-02 | -7.11e-01 | 0.0216 |
153769 | SH3RF2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.31e-11 | 6.13e-01 | -0.1954 |
153769 | SH3RF2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.32e-02 | -6.82e-01 | -0.2196 |
153769 | SH3RF2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.55e-09 | -6.54e-01 | -0.1207 |
153769 | SH3RF2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.11e-15 | -6.56e-01 | 0.096 |
153769 | SH3RF2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 7.92e-03 | -6.47e-01 | 0.0451 |
153769 | SH3RF2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.02e-04 | -6.09e-01 | 0.0528 |
153769 | SH3RF2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.32e-03 | -4.90e-01 | 0.0338 |
153769 | SH3RF2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.75e-07 | -4.92e-01 | 0.0674 |
153769 | SH3RF2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.45e-06 | -5.01e-01 | 0.0112 |
153769 | SH3RF2 | HTA11_11156_2000001011 | Human | Colorectum | AD | 4.95e-04 | -9.90e-01 | 0.0397 |
153769 | SH3RF2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.46e-03 | -4.80e-01 | 0.0588 |
153769 | SH3RF2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.17e-31 | -7.30e-01 | 0.294 |
153769 | SH3RF2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.54e-28 | -7.37e-01 | 0.3859 |
153769 | SH3RF2 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.81e-05 | -5.82e-01 | 0.2585 |
153769 | SH3RF2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.68e-64 | -1.13e+00 | 0.3005 |
153769 | SH3RF2 | F007 | Human | Colorectum | FAP | 1.22e-12 | -7.49e-01 | 0.1176 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:004586210 | Cervix | CC | positive regulation of proteolysis | 95/2311 | 372/18723 | 1.84e-12 | 6.86e-10 | 95 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:190332010 | Cervix | CC | regulation of protein modification by small protein conjugation or removal | 66/2311 | 242/18723 | 2.31e-10 | 3.46e-08 | 66 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:003139610 | Cervix | CC | regulation of protein ubiquitination | 59/2311 | 210/18723 | 5.90e-10 | 7.51e-08 | 59 |
GO:190305010 | Cervix | CC | regulation of proteolysis involved in cellular protein catabolic process | 60/2311 | 221/18723 | 1.82e-09 | 1.98e-07 | 60 |
GO:200005810 | Cervix | CC | regulation of ubiquitin-dependent protein catabolic process | 47/2311 | 164/18723 | 1.63e-08 | 1.25e-06 | 47 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:190336410 | Cervix | CC | positive regulation of cellular protein catabolic process | 43/2311 | 155/18723 | 1.80e-07 | 8.28e-06 | 43 |
GO:003139710 | Cervix | CC | negative regulation of protein ubiquitination | 28/2311 | 83/18723 | 3.32e-07 | 1.35e-05 | 28 |
GO:006113610 | Cervix | CC | regulation of proteasomal protein catabolic process | 48/2311 | 187/18723 | 4.63e-07 | 1.77e-05 | 48 |
GO:003243410 | Cervix | CC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 38/2311 | 134/18723 | 4.99e-07 | 1.88e-05 | 38 |
GO:00310988 | Cervix | CC | stress-activated protein kinase signaling cascade | 58/2311 | 247/18723 | 8.02e-07 | 2.89e-05 | 58 |
GO:190332110 | Cervix | CC | negative regulation of protein modification by small protein conjugation or removal | 29/2311 | 95/18723 | 2.15e-06 | 6.55e-05 | 29 |
GO:00514038 | Cervix | CC | stress-activated MAPK cascade | 55/2311 | 239/18723 | 2.96e-06 | 8.31e-05 | 55 |
GO:00703027 | Cervix | CC | regulation of stress-activated protein kinase signaling cascade | 46/2311 | 195/18723 | 9.35e-06 | 2.11e-04 | 46 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SH3RF2 | SNV | Missense_Mutation | novel | c.421N>A | p.Pro141Thr | p.P141T | Q8TEC5 | protein_coding | deleterious(0) | possibly_damaging(0.75) | TCGA-69-A59K-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SH3RF2 | SNV | Missense_Mutation | novel | c.1274C>A | p.Thr425Asn | p.T425N | Q8TEC5 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-73-A9RS-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD |
SH3RF2 | SNV | Missense_Mutation | c.964N>A | p.Glu322Lys | p.E322K | Q8TEC5 | protein_coding | deleterious(0.02) | possibly_damaging(0.626) | TCGA-18-3415-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | navelbine | CR | |
SH3RF2 | SNV | Missense_Mutation | c.689N>T | p.Trp230Leu | p.W230L | Q8TEC5 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-18-3419-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SH3RF2 | SNV | Missense_Mutation | c.694N>A | p.Glu232Lys | p.E232K | Q8TEC5 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-22-4601-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SH3RF2 | SNV | Missense_Mutation | rs552475882 | c.1784C>T | p.Ser595Phe | p.S595F | Q8TEC5 | protein_coding | deleterious(0) | possibly_damaging(0.58) | TCGA-34-2596-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SH3RF2 | SNV | Missense_Mutation | novel | c.1036N>T | p.Val346Phe | p.V346F | Q8TEC5 | protein_coding | tolerated(0.71) | benign(0) | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SH3RF2 | SNV | Missense_Mutation | novel | c.1679C>G | p.Pro560Arg | p.P560R | Q8TEC5 | protein_coding | deleterious(0.02) | benign(0.08) | TCGA-43-8115-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
SH3RF2 | SNV | Missense_Mutation | c.1280N>T | p.Arg427Leu | p.R427L | Q8TEC5 | protein_coding | tolerated(0.1) | possibly_damaging(0.9) | TCGA-46-3765-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SH3RF2 | SNV | Missense_Mutation | novel | c.1045A>T | p.Ser349Cys | p.S349C | Q8TEC5 | protein_coding | deleterious(0.01) | possibly_damaging(0.707) | TCGA-63-A5MT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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