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Gene: SGCD |
Gene summary for SGCD |
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Gene information | Species | Human | Gene symbol | SGCD | Gene ID | 6444 |
Gene name | sarcoglycan delta | |
Gene Alias | 35DAG | |
Cytomap | 5q33.2-q33.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q92629 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6444 | SGCD | AEH-subject1 | Human | Endometrium | AEH | 1.61e-66 | 1.31e+00 | -0.3059 |
6444 | SGCD | AEH-subject2 | Human | Endometrium | AEH | 3.21e-28 | 8.90e-01 | -0.2525 |
6444 | SGCD | AEH-subject3 | Human | Endometrium | AEH | 4.54e-35 | 8.74e-01 | -0.2576 |
6444 | SGCD | AEH-subject4 | Human | Endometrium | AEH | 2.11e-17 | 7.22e-01 | -0.2657 |
6444 | SGCD | AEH-subject5 | Human | Endometrium | AEH | 5.86e-68 | 1.44e+00 | -0.2953 |
6444 | SGCD | EEC-subject1 | Human | Endometrium | EEC | 3.73e-61 | 1.24e+00 | -0.2682 |
6444 | SGCD | EEC-subject2 | Human | Endometrium | EEC | 5.32e-106 | 1.65e+00 | -0.2607 |
6444 | SGCD | EEC-subject4 | Human | Endometrium | EEC | 1.73e-22 | 8.47e-01 | -0.2571 |
6444 | SGCD | EEC-subject5 | Human | Endometrium | EEC | 9.46e-13 | 5.27e-01 | -0.249 |
6444 | SGCD | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 7.25e-03 | 1.81e-01 | -0.1869 |
6444 | SGCD | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.33e-05 | 2.84e-01 | -0.1875 |
6444 | SGCD | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 6.29e-05 | 2.52e-01 | -0.1883 |
6444 | SGCD | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.04e-05 | 2.49e-01 | -0.1917 |
6444 | SGCD | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 3.16e-05 | 2.41e-01 | -0.1916 |
6444 | SGCD | PTC07 | Human | Thyroid | PTC | 2.03e-04 | -8.56e-03 | 0.2044 |
6444 | SGCD | ATC13 | Human | Thyroid | ATC | 1.62e-68 | 1.22e+00 | 0.34 |
6444 | SGCD | ATC5 | Human | Thyroid | ATC | 1.77e-68 | 1.30e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00605376 | Endometrium | AEH | muscle tissue development | 83/2100 | 403/18723 | 2.57e-08 | 1.50e-06 | 83 |
GO:00147065 | Endometrium | AEH | striated muscle tissue development | 75/2100 | 384/18723 | 1.06e-06 | 3.62e-05 | 75 |
GO:00075174 | Endometrium | AEH | muscle organ development | 60/2100 | 327/18723 | 8.19e-05 | 1.22e-03 | 60 |
GO:0048738 | Endometrium | AEH | cardiac muscle tissue development | 43/2100 | 236/18723 | 9.06e-04 | 8.30e-03 | 43 |
GO:006053713 | Endometrium | EEC | muscle tissue development | 82/2168 | 403/18723 | 2.14e-07 | 9.38e-06 | 82 |
GO:001470612 | Endometrium | EEC | striated muscle tissue development | 74/2168 | 384/18723 | 6.64e-06 | 1.57e-04 | 74 |
GO:000751712 | Endometrium | EEC | muscle organ development | 59/2168 | 327/18723 | 3.49e-04 | 3.85e-03 | 59 |
GO:00487381 | Endometrium | EEC | cardiac muscle tissue development | 42/2168 | 236/18723 | 3.00e-03 | 2.10e-02 | 42 |
GO:006053719 | Thyroid | PTC | muscle tissue development | 156/5968 | 403/18723 | 1.98e-03 | 1.06e-02 | 156 |
GO:001470617 | Thyroid | PTC | striated muscle tissue development | 144/5968 | 384/18723 | 1.05e-02 | 4.22e-02 | 144 |
GO:006053724 | Thyroid | ATC | muscle tissue development | 181/6293 | 403/18723 | 1.27e-06 | 1.62e-05 | 181 |
GO:001470622 | Thyroid | ATC | striated muscle tissue development | 168/6293 | 384/18723 | 1.91e-05 | 1.73e-04 | 168 |
GO:000751716 | Thyroid | ATC | muscle organ development | 139/6293 | 327/18723 | 4.45e-04 | 2.64e-03 | 139 |
GO:004873811 | Thyroid | ATC | cardiac muscle tissue development | 103/6293 | 236/18723 | 7.93e-04 | 4.37e-03 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541625 | Endometrium | AEH | Viral myocarditis | 27/1197 | 60/8465 | 6.98e-09 | 1.13e-07 | 8.30e-08 | 27 |
hsa05416111 | Endometrium | AEH | Viral myocarditis | 27/1197 | 60/8465 | 6.98e-09 | 1.13e-07 | 8.30e-08 | 27 |
hsa0541626 | Endometrium | EEC | Viral myocarditis | 28/1237 | 60/8465 | 2.81e-09 | 5.77e-08 | 4.30e-08 | 28 |
hsa0541635 | Endometrium | EEC | Viral myocarditis | 28/1237 | 60/8465 | 2.81e-09 | 5.77e-08 | 4.30e-08 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SGCD | SNV | Missense_Mutation | c.757N>A | p.Pro253Thr | p.P253T | Q92629 | protein_coding | tolerated(0.22) | benign(0.015) | TCGA-18-3414-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SGCD | SNV | Missense_Mutation | c.522N>A | p.Phe174Leu | p.F174L | Q92629 | protein_coding | deleterious(0.02) | probably_damaging(0.969) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SGCD | SNV | Missense_Mutation | c.241G>A | p.Gly81Arg | p.G81R | Q92629 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SGCD | SNV | Missense_Mutation | rs556208970 | c.142N>T | p.Val48Leu | p.V48L | Q92629 | protein_coding | tolerated(0.07) | possibly_damaging(0.546) | TCGA-39-5040-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |
SGCD | SNV | Missense_Mutation | c.613N>A | p.Pro205Thr | p.P205T | Q92629 | protein_coding | tolerated(0.05) | probably_damaging(0.998) | TCGA-46-6025-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | |
SGCD | SNV | Missense_Mutation | c.70N>C | p.Lys24Gln | p.K24Q | Q92629 | protein_coding | tolerated(0.14) | possibly_damaging(0.899) | TCGA-56-6546-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SGCD | SNV | Missense_Mutation | novel | c.457N>C | p.Asp153His | p.D153H | Q92629 | protein_coding | deleterious(0.02) | possibly_damaging(0.873) | TCGA-77-8140-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SGCD | SNV | Missense_Mutation | novel | c.197G>T | p.Gly66Val | p.G66V | Q92629 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-NC-A5HK-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SGCD | SNV | Missense_Mutation | rs199520526 | c.755N>T | p.Thr252Met | p.T252M | Q92629 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-CR-6471-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | PD |
SGCD | SNV | Missense_Mutation | novel | c.579G>T | p.Leu193Phe | p.L193F | Q92629 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CR-7370-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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