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Gene: SERPINB4 |
Gene summary for SERPINB4 |
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Gene information | Species | Human | Gene symbol | SERPINB4 | Gene ID | 6318 |
Gene name | serpin family B member 4 | |
Gene Alias | LEUPIN | |
Cytomap | 18q21.33 | |
Gene Type | protein-coding | GO ID | GO:0001906 | UniProtAcc | P48594 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6318 | SERPINB4 | CA_HPV_1 | Human | Cervix | CC | 7.16e-07 | -3.98e-01 | 0.0264 |
6318 | SERPINB4 | CA_HPV_3 | Human | Cervix | CC | 1.43e-05 | -3.03e-01 | 0.0414 |
6318 | SERPINB4 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 2.06e-15 | -5.11e-01 | 0.0116 |
6318 | SERPINB4 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 4.92e-16 | -4.95e-01 | 0.0208 |
6318 | SERPINB4 | N_HPV_1 | Human | Cervix | N_HPV | 7.74e-11 | -4.45e-01 | 0.0079 |
6318 | SERPINB4 | Tumor | Human | Cervix | CC | 3.92e-46 | 1.09e+00 | 0.1241 |
6318 | SERPINB4 | sample3 | Human | Cervix | CC | 1.46e-38 | 9.29e-01 | 0.1387 |
6318 | SERPINB4 | H2 | Human | Cervix | HSIL_HPV | 5.70e-03 | -2.59e-01 | 0.0632 |
6318 | SERPINB4 | L1 | Human | Cervix | CC | 1.51e-49 | 1.36e+00 | 0.0802 |
6318 | SERPINB4 | T3 | Human | Cervix | CC | 1.10e-39 | 9.42e-01 | 0.1389 |
6318 | SERPINB4 | P5T-E | Human | Esophagus | ESCC | 5.30e-21 | 7.57e-01 | 0.1327 |
6318 | SERPINB4 | P23T-E | Human | Esophagus | ESCC | 2.37e-13 | 1.62e+00 | 0.108 |
6318 | SERPINB4 | P36T-E | Human | Esophagus | ESCC | 6.23e-11 | 6.75e-01 | 0.1187 |
6318 | SERPINB4 | P37T-E | Human | Esophagus | ESCC | 6.05e-08 | 4.82e-01 | 0.1371 |
6318 | SERPINB4 | P62T-E | Human | Esophagus | ESCC | 1.17e-28 | 2.05e+00 | 0.1302 |
6318 | SERPINB4 | P74T-E | Human | Esophagus | ESCC | 4.76e-19 | 2.85e+00 | 0.1479 |
6318 | SERPINB4 | P75T-E | Human | Esophagus | ESCC | 2.20e-17 | 8.28e-01 | 0.1125 |
6318 | SERPINB4 | P76T-E | Human | Esophagus | ESCC | 3.75e-03 | 6.55e-01 | 0.1207 |
6318 | SERPINB4 | P82T-E | Human | Esophagus | ESCC | 4.14e-03 | 1.39e+00 | 0.1072 |
6318 | SERPINB4 | P107T-E | Human | Esophagus | ESCC | 1.03e-13 | 9.21e-01 | 0.171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
GO:00026837 | Cervix | CC | negative regulation of immune system process | 94/2311 | 434/18723 | 2.63e-08 | 1.87e-06 | 94 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:00513469 | Cervix | CC | negative regulation of hydrolase activity | 81/2311 | 379/18723 | 4.27e-07 | 1.67e-05 | 81 |
GO:00104669 | Cervix | CC | negative regulation of peptidase activity | 60/2311 | 262/18723 | 1.27e-06 | 4.34e-05 | 60 |
GO:001095110 | Cervix | CC | negative regulation of endopeptidase activity | 56/2311 | 252/18723 | 7.43e-06 | 1.74e-04 | 56 |
GO:00028315 | Cervix | CC | regulation of response to biotic stimulus | 67/2311 | 327/18723 | 1.79e-05 | 3.36e-04 | 67 |
GO:00028322 | Cervix | CC | negative regulation of response to biotic stimulus | 27/2311 | 108/18723 | 2.27e-04 | 2.55e-03 | 27 |
GO:00507773 | Cervix | CC | negative regulation of immune response | 41/2311 | 194/18723 | 3.63e-04 | 3.76e-03 | 41 |
GO:00321022 | Cervix | CC | negative regulation of response to external stimulus | 75/2311 | 420/18723 | 5.96e-04 | 5.61e-03 | 75 |
GO:00450882 | Cervix | CC | regulation of innate immune response | 44/2311 | 218/18723 | 6.40e-04 | 5.97e-03 | 44 |
GO:00026983 | Cervix | CC | negative regulation of immune effector process | 26/2311 | 110/18723 | 7.40e-04 | 6.63e-03 | 26 |
GO:00026973 | Cervix | CC | regulation of immune effector process | 62/2311 | 339/18723 | 9.25e-04 | 7.84e-03 | 62 |
GO:00313423 | Cervix | CC | negative regulation of cell killing | 10/2311 | 28/18723 | 1.28e-03 | 1.02e-02 | 10 |
GO:00458243 | Cervix | CC | negative regulation of innate immune response | 18/2311 | 71/18723 | 2.01e-03 | 1.47e-02 | 18 |
GO:0031348 | Cervix | CC | negative regulation of defense response | 48/2311 | 258/18723 | 2.30e-03 | 1.65e-02 | 48 |
GO:00019067 | Cervix | CC | cell killing | 37/2311 | 188/18723 | 2.61e-03 | 1.80e-02 | 37 |
GO:0045953 | Cervix | CC | negative regulation of natural killer cell mediated cytotoxicity | 7/2311 | 18/18723 | 3.99e-03 | 2.48e-02 | 7 |
GO:0002443 | Cervix | CC | leukocyte mediated immunity | 73/2311 | 440/18723 | 5.01e-03 | 2.98e-02 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051465 | Cervix | CC | Amoebiasis | 29/1267 | 102/8465 | 3.31e-04 | 1.70e-03 | 1.01e-03 | 29 |
hsa0514612 | Cervix | CC | Amoebiasis | 29/1267 | 102/8465 | 3.31e-04 | 1.70e-03 | 1.01e-03 | 29 |
hsa051468 | Oral cavity | OSCC | Amoebiasis | 59/3704 | 102/8465 | 2.78e-03 | 7.17e-03 | 3.65e-03 | 59 |
hsa0514615 | Oral cavity | OSCC | Amoebiasis | 59/3704 | 102/8465 | 2.78e-03 | 7.17e-03 | 3.65e-03 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SERPINB4 | SNV | Missense_Mutation | c.91N>A | p.Pro31Thr | p.P31T | P48594 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-6776-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SERPINB4 | SNV | Missense_Mutation | c.664N>C | p.Ala222Pro | p.A222P | P48594 | protein_coding | deleterious(0.02) | possibly_damaging(0.908) | TCGA-44-A479-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SERPINB4 | SNV | Missense_Mutation | c.1107C>A | p.Phe369Leu | p.F369L | P48594 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-44-A4SS-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SERPINB4 | SNV | Missense_Mutation | c.526N>A | p.Leu176Ile | p.L176I | P48594 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
SERPINB4 | SNV | Missense_Mutation | c.934N>C | p.Ala312Pro | p.A312P | P48594 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SERPINB4 | SNV | Missense_Mutation | c.1042N>T | p.Ala348Ser | p.A348S | P48594 | protein_coding | tolerated(0.11) | benign(0.005) | TCGA-55-8514-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SERPINB4 | SNV | Missense_Mutation | c.284N>A | p.Ser95Tyr | p.S95Y | P48594 | protein_coding | tolerated(0.05) | possibly_damaging(0.884) | TCGA-55-A494-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SERPINB4 | SNV | Missense_Mutation | c.559N>A | p.Glu187Lys | p.E187K | P48594 | protein_coding | tolerated(0.14) | benign(0.012) | TCGA-62-A46P-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SERPINB4 | SNV | Missense_Mutation | c.98G>A | p.Ser33Asn | p.S33N | P48594 | protein_coding | tolerated(0.09) | possibly_damaging(0.518) | TCGA-73-4677-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SERPINB4 | SNV | Missense_Mutation | novel | c.544T>A | p.Phe182Ile | p.F182I | P48594 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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