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Gene: SEPT14 |
Gene summary for SEPT14 |
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Gene information | Species | Human | Gene symbol | SEPT14 | Gene ID | 346288 |
Gene name | septin 14 | |
Gene Alias | SEPT14 | |
Cytomap | 7p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q6ZU15 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
346288 | SEPT14 | S014 | Human | Liver | HCC | 1.67e-14 | 5.20e-01 | 0.2254 |
346288 | SEPT14 | S015 | Human | Liver | HCC | 1.66e-05 | 2.56e-01 | 0.2375 |
346288 | SEPT14 | S016 | Human | Liver | HCC | 1.56e-15 | 5.17e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SEPT14 | SNV | Missense_Mutation | novel | c.1062N>T | p.Gln354His | p.Q354H | Q6ZU15 | protein_coding | tolerated(0.05) | benign(0.021) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEPT14 | SNV | Missense_Mutation | novel | c.856N>A | p.Asp286Asn | p.D286N | Q6ZU15 | protein_coding | tolerated(0.06) | possibly_damaging(0.88) | TCGA-EY-A54A-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR |
SEPT14 | SNV | Missense_Mutation | rs201042996 | c.143N>A | p.Arg48Gln | p.R48Q | Q6ZU15 | protein_coding | tolerated(1) | benign(0.001) | TCGA-QF-A5YS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
SEPT14 | SNV | Missense_Mutation | c.235G>T | p.Asp79Tyr | p.D79Y | Q6ZU15 | protein_coding | deleterious(0.02) | possibly_damaging(0.878) | TCGA-QS-A5YQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
SEPT14 | SNV | Missense_Mutation | rs370850884 | c.443N>A | p.Arg148His | p.R148H | Q6ZU15 | protein_coding | deleterious(0.01) | possibly_damaging(0.828) | TCGA-BC-A10S-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
SEPT14 | SNV | Missense_Mutation | c.1127A>T | p.Asp376Val | p.D376V | Q6ZU15 | protein_coding | tolerated(0.22) | benign(0.006) | TCGA-05-5428-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | |
SEPT14 | SNV | Missense_Mutation | novel | c.176N>T | p.Gly59Val | p.G59V | Q6ZU15 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-44-4112-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SEPT14 | SNV | Missense_Mutation | novel | c.55N>A | p.Gln19Lys | p.Q19K | Q6ZU15 | protein_coding | tolerated(0.56) | benign(0.022) | TCGA-44-5644-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SEPT14 | SNV | Missense_Mutation | c.170N>T | p.Cys57Phe | p.C57F | Q6ZU15 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-49-AARQ-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SEPT14 | SNV | Missense_Mutation | novel | c.912N>A | p.His304Gln | p.H304Q | Q6ZU15 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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