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Gene: SCGN |
Gene summary for SCGN |
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Gene information | Species | Human | Gene symbol | SCGN | Gene ID | 10590 |
Gene name | secretagogin, EF-hand calcium binding protein | |
Gene Alias | CALBL | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006873 | UniProtAcc | O76038 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10590 | SCGN | S43 | Human | Liver | Cirrhotic | 4.22e-11 | -4.86e-01 | -0.0187 |
10590 | SCGN | HCC1_Meng | Human | Liver | HCC | 9.16e-55 | -6.07e-02 | 0.0246 |
10590 | SCGN | HCC2_Meng | Human | Liver | HCC | 4.05e-12 | -5.15e-01 | 0.0107 |
10590 | SCGN | cirrhotic1 | Human | Liver | Cirrhotic | 1.32e-12 | 5.37e-02 | 0.0202 |
10590 | SCGN | cirrhotic2 | Human | Liver | Cirrhotic | 9.25e-14 | 5.71e-02 | 0.0201 |
10590 | SCGN | cirrhotic3 | Human | Liver | Cirrhotic | 1.23e-04 | -2.84e-01 | 0.0215 |
10590 | SCGN | HCC5 | Human | Liver | HCC | 1.53e-04 | -5.20e-01 | 0.4932 |
10590 | SCGN | Pt13.a | Human | Liver | HCC | 1.08e-13 | -5.13e-01 | 0.021 |
10590 | SCGN | Pt13.b | Human | Liver | HCC | 2.19e-09 | -5.20e-01 | 0.0251 |
10590 | SCGN | Pt13.c | Human | Liver | HCC | 1.20e-05 | -5.20e-01 | 0.0076 |
10590 | SCGN | Pt14.d | Human | Liver | HCC | 3.01e-11 | -5.12e-01 | 0.0143 |
10590 | SCGN | S014 | Human | Liver | HCC | 3.55e-03 | -4.76e-01 | 0.2254 |
10590 | SCGN | S027 | Human | Liver | HCC | 2.17e-04 | 1.26e+00 | 0.2446 |
10590 | SCGN | S028 | Human | Liver | HCC | 2.85e-15 | 1.51e+00 | 0.2503 |
10590 | SCGN | S029 | Human | Liver | HCC | 2.31e-12 | 1.50e+00 | 0.2581 |
10590 | SCGN | HTA12-15-2 | Human | Pancreas | PDAC | 1.08e-16 | 1.01e+00 | 0.2315 |
10590 | SCGN | HTA12-23-1 | Human | Pancreas | PDAC | 4.86e-11 | 9.98e-01 | 0.3405 |
10590 | SCGN | HTA12-25-1 | Human | Pancreas | PDAC | 1.42e-09 | 8.76e-01 | 0.313 |
10590 | SCGN | HTA12-26-1 | Human | Pancreas | PDAC | 9.47e-26 | 1.12e+00 | 0.3728 |
10590 | SCGN | HTA12-29-1 | Human | Pancreas | PDAC | 1.57e-39 | 8.62e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCGN | SNV | Missense_Mutation | rs753222150 | c.67N>G | p.Arg23Gly | p.R23G | O76038 | protein_coding | deleterious(0.02) | benign(0.199) | TCGA-77-7142-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SCGN | SNV | Missense_Mutation | novel | c.464G>A | p.Gly155Asp | p.G155D | O76038 | protein_coding | tolerated(1) | benign(0) | TCGA-85-8584-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SCGN | SNV | Missense_Mutation | rs148531052 | c.169G>A | p.Ala57Thr | p.A57T | O76038 | protein_coding | tolerated(0.38) | benign(0) | TCGA-NC-A5HQ-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
SCGN | SNV | Missense_Mutation | novel | c.308C>A | p.Pro103Gln | p.P103Q | O76038 | protein_coding | tolerated(0.06) | benign(0.233) | TCGA-CN-5360-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
SCGN | SNV | Missense_Mutation | novel | c.396N>A | p.Asn132Lys | p.N132K | O76038 | protein_coding | tolerated(0.08) | benign(0.076) | TCGA-CV-7245-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SCGN | SNV | Missense_Mutation | rs143515197 | c.629N>T | p.Asp210Val | p.D210V | O76038 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CV-7432-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SCGN | SNV | Missense_Mutation | rs749383125 | c.102N>C | p.Glu34Asp | p.E34D | O76038 | protein_coding | tolerated(0.12) | benign(0.142) | TCGA-D6-A6ES-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SCGN | SNV | Missense_Mutation | rs376721140 | c.230N>A | p.Arg77His | p.R77H | O76038 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SCGN | SNV | Missense_Mutation | c.431C>T | p.Ala144Val | p.A144V | O76038 | protein_coding | tolerated(0.29) | benign(0) | TCGA-BR-8373-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
SCGN | SNV | Missense_Mutation | rs148850055 | c.502C>T | p.Arg168Trp | p.R168W | O76038 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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