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Gene: SASS6 |
Gene summary for SASS6 |
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Gene information | Species | Human | Gene symbol | SASS6 | Gene ID | 163786 |
Gene name | SAS-6 centriolar assembly protein | |
Gene Alias | MCPH14 | |
Cytomap | 1p21.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q495U0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
163786 | SASS6 | LZE2T | Human | Esophagus | ESCC | 9.54e-06 | 5.58e-01 | 0.082 |
163786 | SASS6 | P2T-E | Human | Esophagus | ESCC | 2.27e-21 | 3.76e-01 | 0.1177 |
163786 | SASS6 | P4T-E | Human | Esophagus | ESCC | 6.27e-06 | 1.66e-01 | 0.1323 |
163786 | SASS6 | P5T-E | Human | Esophagus | ESCC | 4.98e-10 | 2.45e-01 | 0.1327 |
163786 | SASS6 | P8T-E | Human | Esophagus | ESCC | 4.40e-09 | 1.83e-01 | 0.0889 |
163786 | SASS6 | P10T-E | Human | Esophagus | ESCC | 1.85e-18 | 2.80e-01 | 0.116 |
163786 | SASS6 | P12T-E | Human | Esophagus | ESCC | 2.67e-13 | 3.42e-01 | 0.1122 |
163786 | SASS6 | P16T-E | Human | Esophagus | ESCC | 9.35e-10 | 2.05e-01 | 0.1153 |
163786 | SASS6 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.53e-01 | 0.1278 |
163786 | SASS6 | P20T-E | Human | Esophagus | ESCC | 3.20e-07 | 1.86e-01 | 0.1124 |
163786 | SASS6 | P21T-E | Human | Esophagus | ESCC | 2.97e-02 | 1.14e-01 | 0.1617 |
163786 | SASS6 | P23T-E | Human | Esophagus | ESCC | 2.33e-11 | 2.86e-01 | 0.108 |
163786 | SASS6 | P26T-E | Human | Esophagus | ESCC | 2.17e-03 | 1.38e-01 | 0.1276 |
163786 | SASS6 | P27T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.41e-01 | 0.1055 |
163786 | SASS6 | P28T-E | Human | Esophagus | ESCC | 6.08e-15 | 3.43e-01 | 0.1149 |
163786 | SASS6 | P30T-E | Human | Esophagus | ESCC | 7.79e-07 | 2.51e-01 | 0.137 |
163786 | SASS6 | P31T-E | Human | Esophagus | ESCC | 6.50e-08 | 2.49e-01 | 0.1251 |
163786 | SASS6 | P32T-E | Human | Esophagus | ESCC | 6.74e-08 | 2.82e-01 | 0.1666 |
163786 | SASS6 | P36T-E | Human | Esophagus | ESCC | 2.09e-07 | 2.32e-01 | 0.1187 |
163786 | SASS6 | P37T-E | Human | Esophagus | ESCC | 2.57e-08 | 1.95e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070982 | Esophagus | ESCC | centrosome cycle | 85/8552 | 130/18723 | 4.41e-06 | 4.69e-05 | 85 |
GO:00310233 | Esophagus | ESCC | microtubule organizing center organization | 92/8552 | 143/18723 | 5.04e-06 | 5.31e-05 | 92 |
GO:00070981 | Oral cavity | OSCC | centrosome cycle | 66/7305 | 130/18723 | 4.17e-03 | 1.70e-02 | 66 |
GO:00310232 | Oral cavity | OSCC | microtubule organizing center organization | 70/7305 | 143/18723 | 9.71e-03 | 3.44e-02 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SASS6 | SNV | Missense_Mutation | novel | c.1483N>C | p.Thr495Pro | p.T495P | Q6UVJ0 | protein_coding | tolerated(0.28) | benign(0.015) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
SASS6 | SNV | Missense_Mutation | novel | c.332N>A | p.Ser111Tyr | p.S111Y | Q6UVJ0 | protein_coding | tolerated(0.14) | benign(0.132) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
SASS6 | SNV | Missense_Mutation | novel | c.260N>G | p.Phe87Cys | p.F87C | Q6UVJ0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SASS6 | deletion | Frame_Shift_Del | novel | c.1397delN | p.Asn466IlefsTer5 | p.N466Ifs*5 | Q6UVJ0 | protein_coding | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
SASS6 | deletion | Frame_Shift_Del | rs763290832 | c.170delT | p.Leu57TyrfsTer14 | p.L57Yfs*14 | Q6UVJ0 | protein_coding | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SASS6 | deletion | Frame_Shift_Del | novel | c.567delN | p.Lys189AsnfsTer4 | p.K189Nfs*4 | Q6UVJ0 | protein_coding | TCGA-B5-A0JV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
SASS6 | insertion | Frame_Shift_Ins | novel | c.1368_1369insA | p.Leu457ThrfsTer2 | p.L457Tfs*2 | Q6UVJ0 | protein_coding | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SASS6 | deletion | Frame_Shift_Del | novel | c.1906delT | p.Ser636LeufsTer35 | p.S636Lfs*35 | Q6UVJ0 | protein_coding | TCGA-DD-AADG-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
SASS6 | SNV | Missense_Mutation | novel | c.1576N>T | p.Gly526Trp | p.G526W | Q6UVJ0 | protein_coding | deleterious(0) | possibly_damaging(0.569) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
SASS6 | SNV | Missense_Mutation | novel | c.233T>G | p.Val78Gly | p.V78G | Q6UVJ0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-38-4631-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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